Specifications
- Purity
- ≥99% (Titration)
- Appearance
- White crystals or crystalline powder
- Identity
- 1H-NMR
Properties
- Solvents
- water
- Melting Point
- 197-204°C
Available from stock
4-Aminobutanoic acid
- SKU
- G0043
Category: Amino Acids, Peptides, Proteins
- Synonyms
- γ-Aminobutyric acid , 4-Aminobutanoic acid , GABA , Piperidic acid , Piperidinic acid
- 56-12-2
- CAS-Number
- C4H9NO2
- Molecular Formula
- 103.12
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- An amino acid that functions as the major inhibitory neurotransmitter in the mammalian central nervous system and also functions as a neuromodulator in some peripheral tissues. GABAA and GABAB receptor agonist that increases Cl? conductance. GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neuronal processes. This binding causes the opening of ion channels to allow the flow of either negatively charged chloride ions into the cell or positively charged potassium ions out of the cell. This action results in a negative change in the transmembrane potential, usually causing hyperpolarization. GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation and anaesthetics. GABA can also influence heart rate and blood pressure and function as a immunomodulator.
- Smiles
- OC(CCCN)=O
- InChi Key
- BTCSSZJGUNDROE-UHFFFAOYSA-N
- References
- H.A. Al-Wadei, et al., Mol. Nutr. Food Res. 55, 1745 (2011) , Z. Jin, et al., Amino Acids 45, 87 (2013) , C.A. Huebner & K. Holthoff, Front. Cell Neurosci. 7, 177 (2013) , T. Crowley, et al., Brain Behav. Immun. 54, 260 (2016) , N.X. Tritsch, et al., Nat. Rev. Neurosci. 17, 139 (2016) , R. Mazzoli & E. Pessione, Front. Microbiol. 7, 1934 (2016)
- InChi
- InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
An amino acid that functions as the major inhibitory neurotransmitter in the mammalian central nervous system and also functions as a neuromodulator in some peripheral tissues. GABAA and GABAB receptor agonist that increases Cl? conductance. GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neuronal processes. This binding causes the opening of ion channels to allow the flow of either negatively charged chloride ions into the cell or positively charged potassium ions out of the cell. This action results in a negative change in the transmembrane potential, usually causing hyperpolarization. GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation and anaesthetics. GABA can also influence heart rate and blood pressure and function as a immunomodulator.
Additional information
| Synonyms | γ-Aminobutyric acid, 4-Aminobutanoic acid, GABA, Piperidic acid, Piperidinic acid |
|---|---|
| Purity | ≥99% (Titration) |
| Appearance | White crystals or crystalline powder |
| CAS-Number | 56-12-2 |
| Molecular Formula | C4H9NO2 |
| Molecular Weight | 103.12 |
| Identity | 1H-NMR |
| Solvents | water |
| Melting Point | 197-204°C |
| Smiles | OC(CCCN)=O |
| InChi Key | BTCSSZJGUNDROE-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | H.A. Al-Wadei, et al., Mol. Nutr. Food Res. 55, 1745 (2011), Z. Jin, et al., Amino Acids 45, 87 (2013), C.A. Huebner & K. Holthoff, Front. Cell Neurosci. 7, 177 (2013), T. Crowley, et al., Brain Behav. Immun. 54, 260 (2016), N.X. Tritsch, et al., Nat. Rev. Neurosci. 17, 139 (2016), R. Mazzoli & E. Pessione, Front. Microbiol. 7, 1934 (2016) |
| InChi | InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7) |
| Quantity | 5 g, 50 g, 500 g, Bulk |
