4-Di-2-ASP

Available from stock

4-Di-2-ASP

SKU
D0012

Categories: ,

Synonyms
4-(4-Diethylaminostyryl)-1-methylpyridinium iodide
105802-46-8
CAS-Number
C18H23IN2
Molecular Formula
394.29
Molecular Weight

Specifications

Purity
≥97% (NMR)
Identity
1H-NMR
Appearance
Dark red crystaline powder

Properties

Fluorescence
λex 485 nm, λem 603 nm in methanol
Melting Point
214-216°C (lit.)
Solvents
DMSO, DMF, chloroform

Downloads

Safety Data Sheet
CDX D0012 MSDS.pdf
Long Term Storage
+4°C
Use / Stability
Stable for at least 2 years after receipt when stored at +4°C.
Handling Advice
Protect from light and moisture.
Short Term Storage
+4°C
Shipping
AMBIENT
Transportation
Not dangerous goods
Signal word
Warning
GHS Symbol
GHS07
Precautionary statements
P261, P305 + P351 + P338
Hazard statements
H315, H319, H335
Description
Some cationic mitochondrial dyes such as 4-Di-1-ASP and 4-Di-2-ASP stain presynaptic nerve terminals independent of neuronal activity. The photostable 4-Di-2-ASP dye, which is nontoxic to cells, has been employed to stain living nerve terminals in rabbit corneal epithelium, in rat epidermis and at mouse, snake and frog neuromuscular junctions, as well as to visualize the innervation of the human choroid and whole mounts of the gastrointestinal tract. Methods for using 4-Di-2-ASP to image neuronal cells in live animals have been described (Ex/Em = 488/607 nm).
InChi
InChI=1S/C18H23N2.HI/c1-4-20(5-2)18-10-8-16(9-11-18)6-7-17-12-14-19(3)15-13-17
References
(1) C. Seebacher et al.: Adv. Mat. 13(18), 1374 (2001) , (2) R.S. Wilkinson et al.: J. Neurosci. 14, 3319 (1994) , (3) L. Chen et al.: J. Neurosci. 14, 796 (1994) , (4) M.B. MacIver et al.: J. Neurosci. 13, 4511 (1993) , (5) A.A. Herrera et al.: J. Neurocytol. 19, 67 (1990) , (6) C.A. Nurse et al.: Cell Tissue Res. 255, 125 (1989)
InChi Key
WIPKWLIHFGTFQV-UHFFFAOYSA-M
Smiles
[I-].CCN(CC)C1=CC=C(C=CC2=CC=[N+](C)C=C2)C=C1

Some cationic mitochondrial dyes such as 4-Di-1-ASP and 4-Di-2-ASP stain presynaptic nerve terminals independent of neuronal activity. The photostable 4-Di-2-ASP dye, which is nontoxic to cells, has been employed to stain living nerve terminals in rabbit corneal epithelium, in rat epidermis and at mouse, snake and frog neuromuscular junctions, as well as to visualize the innervation of the human choroid and whole mounts of the gastrointestinal tract. Methods for using 4-Di-2-ASP to image neuronal cells in live animals have been described (Ex/Em = 488/607 nm).

SKU: D0012 Categories: ,

Additional information

Synonyms

4-(4-Diethylaminostyryl)-1-methylpyridinium iodide
Purity

≥97% (NMR)
Appearance

Dark red crystaline powder
CAS-Number

105802-46-8
Molecular Formula

C18H23IN2
Molecular Weight

394.29
Identity

1H-NMR
Solvents

DMSO, DMF, chloroform
Melting Point

214-216°C (lit.)
Fluorescence

λex 485 nm, λem 603 nm in methanol
Smiles

[I-].CCN(CC)C1=CC=C(C=CC2=CC=[N+](C)C=C2)C=C1
InChi Key

WIPKWLIHFGTFQV-UHFFFAOYSA-M
Shipping

AMBIENT
Short Term Storage

+4°C
Long Term Storage

+4°C
Handling Advice

Protect from light and moisture.
Use / Stability

Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements

H315, H319, H335
Precautionary statements

P261, P305 + P351 + P338
GHS Symbol

GHS07
Signal word

Warning
Transportation

Not dangerous goods
References

(1) C. Seebacher et al.: Adv. Mat. 13(18), 1374 (2001), (2) R.S. Wilkinson et al.: J. Neurosci. 14, 3319 (1994), (3) L. Chen et al.: J. Neurosci. 14, 796 (1994), (4) M.B. MacIver et al.: J. Neurosci. 13, 4511 (1993), (5) A.A. Herrera et al.: J. Neurocytol. 19, 67 (1990), (6) C.A. Nurse et al.: Cell Tissue Res. 255, 125 (1989)
InChi

InChI=1S/C18H23N2.HI/c1-4-20(5-2)18-10-8-16(9-11-18)6-7-17-12-14-19(3)15-13-17
Quantity

1 g, 5 g, Bulk

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