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    4-Hydroxyphenylpyruvic acid

    Available from stock

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      4-Hydroxyphenylpyruvic acid

      SKU
      H0013

      Category: Building Blocks, Intermediates, Reagents

      Synonyms
      3-(4-Hydroxyphenyl)-2-oxopropanoic acid , 4-HPPA, p-Hydroxyphenylpyruvic acid
      156-39-8
      CAS-Number
      C9H8O4
      Molecular Formula
      180.16
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Identity
      1H-NMR
      Appearance
      Light yellow crystalline powder

      Properties

      Density
      ~1.4 g/cm3 (Predicted)
      Refractive Index
      n20D 1.60 (Predicted)
      Boiling Point
      ~380.8 °C at 760 mmHg (Predicted)
      Melting Point
      219-220°C (lit.)(dec.)
      Solvents
      water, ethanol (50 mg/ml), ether, methanol

      Downloads

      Safety Data Sheet
      CDX H0013 MSDS.pdf
      Short Term Storage
      +4°C
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      -20°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Signal word
      Warning
      GHS Symbol
      GHS07
      Precautionary statements
      P261-P305 + P351 + P338
      Hazard statements
      H315-H319-H335
      Description
      Keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine.
      InChi
      InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)
      References
      (1) C.H. Doy, et al.: Nature 186, 529 (1960) , (2) W. Loffelhardt & H. Kindl , FEBS Lett 104, 332 (1979) , (3) K. Tomoeda, et al.: Mol. Genet. Metab. 71, 506 (2000) , (4) E. van Dyk & P. Pretorius , BBRC 338, 815 (2005)
      InChi Key
      KKADPXVIOXHVKN-UHFFFAOYSA-N
      Smiles
      OC1=CC=C(CC(C(O)=O)=O)C=C1

      Keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine.

      SKU: H0013 Category: Building Blocks, Intermediates, Reagents
      • Additional information

      Additional information

      Synonyms

      3-(4-Hydroxyphenyl)-2-oxopropanoic acid, 4-HPPA, p-Hydroxyphenylpyruvic acid

      Purity

      ≥98% (HPLC)

      Appearance

      Light yellow crystalline powder

      CAS-Number

      156-39-8

      Molecular Formula

      C9H8O4

      Molecular Weight

      180.16

      Identity

      1H-NMR

      Solvents

      water, ethanol (50 mg/ml), ether, methanol

      Melting Point

      219-220°C (lit.)(dec.)

      Boiling Point

      ~380.8 °C at 760 mmHg (Predicted)

      Refractive Index

      n20D 1.60 (Predicted)

      Density

      ~1.4 g/cm3 (Predicted)

      Smiles

      OC1=CC=C(CC(C(O)=O)=O)C=C1

      InChi Key

      KKADPXVIOXHVKN-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Hazard statements

      H315-H319-H335

      Precautionary statements

      P261-P305 + P351 + P338

      GHS Symbol

      GHS07

      Signal word

      Warning

      Transportation

      Not dangerous goods

      References

      (1) C.H. Doy, et al.: Nature 186, 529 (1960), (2) W. Loffelhardt & H. Kindl, FEBS Lett 104, 332 (1979), (3) K. Tomoeda, et al.: Mol. Genet. Metab. 71, 506 (2000), (4) E. van Dyk & P. Pretorius, BBRC 338, 815 (2005)

      InChi

      InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)

      Quantity

      1 g, 5 g, Bulk

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