Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in ethanol or methanol (both 5mg/ml).
Category: Antibiotics
4-Hydroxytamoxifen is an active metabolite of the chemotherapeutic drug tamoxifen, a selective estrogen receptor modulator (SERM) that acts as an agonist or antagonist in various tissues. 4-Hydroxytamoxifen acts as a tissue-selective agonist–antagonist of the estrogen receptors ER&alpha
Synonyms | Afimoxifene, 4-OHT, cis/trans-4-Hydroxytamoxifen, (E/Z)-4-Hydroxytamoxifen, HTMX, 4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol |
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Purity | ≥98% (HPLC) |
Appearance | White to yellow powder |
CAS-Number | 68392-35-8 |
Molecular Formula | C26H29NO2 |
Molecular Weight | 387.51 |
Identity | 1H-NMR |
Solvents | Soluble in ethanol or methanol (both 5mg/ml). |
Smiles | CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCN(C)C)C=C3 |
InChi Key | TXUZVZSFRXZGTL-QPLCGJKRSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H302-H312-H332-H361 |
Precautionary statements | P280 |
GHS Symbol | GHS07+GHS08 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | [1] N. Terakawa, et al., Cancer 61, 1312 (1988), [2] H. Wiseman, et al., FEBS Lett. 274, 107 (1990), [3] G. Freiss, et al., BBRC 173, 919 (1990), [4] H. Wiseman, et al., Biochem J. 292, 635 (1993), [5] A.M. Davies, et al., Biochem. Soc. Trans. 23, 439S (1995), [6] S.T. Willard, et al., Endocrine 14, 247 (2001), [7] P. Coward, et al., PNAS 98, 8880 (2001), [8] G.B. Tremblay, et al., Endocrinology 142, 4572 (2001), [9] H.K. Crewe, et al., Drug Metab. Dispos. 30, 869 (2002), [10] C.M. Cardoso, et al., Mitochondrion 1, 485 (2002), [11] J.P. Monteiro, et al., Toxicol. In Vitro 17, 629 (2003), [12] Z. Desta, et al., J. Pharmacol. Exp. Ther. 310, 1062 (2004), [13] H. Seeger, et al., Horm. Metab. Res. 36, 277 (2004), [14] E.A. Ariazi & V.C. Jordan, Curr. Top. Med. Chem. 6, 203 (2006) (Review), [15] M.L. Asp, et al., PLoS One 8, e78768 (2013), [16] L. Kohli, et al., Cancer Res. 73, 4395 (2013), [17] L. Duan, et al., Cancer Lett. 353, 290 (2014) |
InChi | InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25- |
Quantity | 50 mg, 250 mg, Bulk |