Available from stock

4-Hydroxytamoxifen

SKU: H0150

Category: Antibiotics

Synonyms: Afimoxifene, 4-OHT, cis/trans-4-Hydroxytamoxifen, (E/Z)-4-Hydroxytamoxifen, HTMX, 4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol; 68392-35-8
CAS-Number: C₂₆H₂₉NO₂
Molecular Formula: 387.51
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to yellow powder
Identity: 1H-NMR

Properties

Solvents: Soluble in ethanol or methanol (both 5mg/ml).

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H302-H312-H332-H361
Precautionary statements: P280
GHS Symbol: GHS07+GHS08
Signal word: Warning
Transportation: Not dangerous goods

Description: 4-Hydroxytamoxifen is an active metabolite of the chemotherapeutic drug tamoxifen, a selective estrogen receptor modulator (SERM) that acts as an agonist or antagonist in various tissues. 4-Hydroxytamoxifen acts as a tissue-selective agonist–antagonist of the estrogen receptors ER&alpha
Smiles: CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCN(C)C)C=C3
InChi Key: TXUZVZSFRXZGTL-QPLCGJKRSA-N
References: [1] N. Terakawa, et al., Cancer 61, 1312 (1988) , [2] H. Wiseman, et al., FEBS Lett. 274, 107 (1990) , [3] G. Freiss, et al., BBRC 173, 919 (1990) , [4] H. Wiseman, et al., Biochem J. 292, 635 (1993) , [5] A.M. Davies, et al., Biochem. Soc. Trans. 23, 439S (1995) , [6] S.T. Willard, et al., Endocrine 14, 247 (2001) , [7] P. Coward, et al., PNAS 98, 8880 (2001) , [8] G.B. Tremblay, et al., Endocrinology 142, 4572 (2001) , [9] H.K. Crewe, et al., Drug Metab. Dispos. 30, 869 (2002) , [10] C.M. Cardoso, et al., Mitochondrion 1, 485 (2002) , [11] J.P. Monteiro, et al., Toxicol. In Vitro 17, 629 (2003) , [12] Z. Desta, et al., J. Pharmacol. Exp. Ther. 310, 1062 (2004) , [13] H. Seeger, et al., Horm. Metab. Res. 36, 277 (2004) , [14] E.A. Ariazi & V.C. Jordan, Curr. Top. Med. Chem. 6, 203 (2006) (Review) , [15] M.L. Asp, et al., PLoS One 8, e78768 (2013) , [16] L. Kohli, et al., Cancer Res. 73, 4395 (2013) , [17] L. Duan, et al., Cancer Lett. 353, 290 (2014)
InChi: InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-

4-Hydroxytamoxifen is an active metabolite of the chemotherapeutic drug tamoxifen, a selective estrogen receptor modulator (SERM) that acts as an agonist or antagonist in various tissues. 4-Hydroxytamoxifen acts as a tissue-selective agonist–antagonist of the estrogen receptors ER&alpha

SKU: H0150 Category: Antibiotics

Additional information

Additional information

Synonyms	Afimoxifene, 4-OHT, cis/trans-4-Hydroxytamoxifen, (E/Z)-4-Hydroxytamoxifen, HTMX, 4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol
Purity	≥98% (HPLC)
Appearance	White to yellow powder
CAS-Number	68392-35-8
Molecular Formula	C26H29NO2
Molecular Weight	387.51
Identity	1H-NMR
Solvents	Soluble in ethanol or methanol (both 5mg/ml).
Smiles	CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCN(C)C)C=C3
InChi Key	TXUZVZSFRXZGTL-QPLCGJKRSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H302-H312-H332-H361
Precautionary statements	P280
GHS Symbol	GHS07+GHS08
Signal word	Warning
Transportation	Not dangerous goods
References	[1] N. Terakawa, et al., Cancer 61, 1312 (1988), [2] H. Wiseman, et al., FEBS Lett. 274, 107 (1990), [3] G. Freiss, et al., BBRC 173, 919 (1990), [4] H. Wiseman, et al., Biochem J. 292, 635 (1993), [5] A.M. Davies, et al., Biochem. Soc. Trans. 23, 439S (1995), [6] S.T. Willard, et al., Endocrine 14, 247 (2001), [7] P. Coward, et al., PNAS 98, 8880 (2001), [8] G.B. Tremblay, et al., Endocrinology 142, 4572 (2001), [9] H.K. Crewe, et al., Drug Metab. Dispos. 30, 869 (2002), [10] C.M. Cardoso, et al., Mitochondrion 1, 485 (2002), [11] J.P. Monteiro, et al., Toxicol. In Vitro 17, 629 (2003), [12] Z. Desta, et al., J. Pharmacol. Exp. Ther. 310, 1062 (2004), [13] H. Seeger, et al., Horm. Metab. Res. 36, 277 (2004), [14] E.A. Ariazi & V.C. Jordan, Curr. Top. Med. Chem. 6, 203 (2006) (Review), [15] M.L. Asp, et al., PLoS One 8, e78768 (2013), [16] L. Kohli, et al., Cancer Res. 73, 4395 (2013), [17] L. Duan, et al., Cancer Lett. 353, 290 (2014)
InChi	InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
Quantity	50 mg, 250 mg, Bulk