Specifications
- Purity
- ≥97% (NMR)
- Appearance
- Light beige powder
- Identity
- 1H-NMR
Properties
- Melting Point
- 90 - 92 °C
Available from stock
4-Methylumbelliferone sodium salt
- SKU
- M0577
Category: Fluorescent Detection
- Synonyms
- 4-MU sodium salt, &beta,-Methylumbelliferone sodium salt, 7-Hydroxy-4-methylcoumarin sodium salt, Mendiaxon sodium salt, Cantabilin sodium salt
- 5980-33-6
- CAS-Number
- C10H7O3 . Na
- Molecular Formula
- 198.15
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Transportation
- Not dangerous goods
- Description
- 4-Methylumbelliferone sodium salt is a salt form of 4-Methylumbelliferone (4-MU), which is a selective inhibitor of hyaluronan (HA) by depletion of UDP-glucuronic acid, the common substrate for HA synthesis and downregulation of hyaluronan synthase 2 and 3, MMP2 and MMP9. Since hyaluronan (HA) is a major component of the extracellular matrix that is synthesized in excess in cancer tissues, 4-MU has been shown to have anti-cancer activity and is involved in angiogenesis, invasion and metastasis of cancer. Fluorescent pH indicator, that is highly fluorescent in alkaline solution. Exhibits a blue fluorescence at pH7. The fluorescence intensity is pH dependent and increases to a maximum at pH10 (plateau above pH10). The fluorescence at pH10.3 is approximately 100 times as intense as at pH7. Spectral data: ?ex=360nm, ?em=448nm, pH > 9. 4-Methylumbelliferone is an indicator also used in the determination of nitric acid and in 4-MU-O-substrates for the kinetic investigation of enzyme activity.
- References
- (1) R.F. Chen, Anal. Lett. 1, 423 (1968) , (2) T. Nakamura, et al., Biochem. Mol. Biol. Int. 43, 263 (1997) , (3) I. Jones, et al., Mol. Gen. Metab. 108, S51 (2003) , (4) I. Kakizaki, et al., J. Biol. Chem. 279, 33281 (2004) , (5) S. Yoshihara, et al., FEBS Lett. 579, 2722 (2005) , (6) R. Nakamura, et al., Cell Biol. Int. 31, 1022 (2007) , (7) D. Vigetti, et al., Glycobiology 19, 537 (2009) , (8) A. Kultti, et al., Exp. Cell Res. 315, 1914 (2009) , (9) H. Urakawa, et al., Int. J. Cancer 130, 454 (2012) , (10) J.A. Garcia-Vilas, et al., J. Agric. Food Chem. 61, 4063 (2013) , (11) H. Zhi, et al., J. Spectrosc. 2013, ID 147128 (2013) , (12) N. Nagy, et al., Front. Immunol. 6, 123 (2015) (Review) , (13) H. Ban, et al., Anticancer Res. 35, 5231 (2015)
- InChi
- InChI=1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9,/h2-5,11H,1H3,/q,+1/p-1
4-Methylumbelliferone sodium salt is a salt form of 4-Methylumbelliferone (4-MU), which is a selective inhibitor of hyaluronan (HA) by depletion of UDP-glucuronic acid, the common substrate for HA synthesis and downregulation of hyaluronan synthase 2 and 3, MMP2 and MMP9. Since hyaluronan (HA) is a major component of the extracellular matrix that is synthesized in excess in cancer tissues, 4-MU has been shown to have anti-cancer activity and is involved in angiogenesis, invasion and metastasis of cancer.
Fluorescent pH indicator, that is highly fluorescent in alkaline solution. Exhibits a blue fluorescence at pH7. The fluorescence intensity is pH dependent and increases to a maximum at pH10 (plateau above pH10). The fluorescence at pH10.3 is approximately 100 times as intense as at pH7. Spectral data: ?ex=360nm, ?em=448nm, pH > 9. 4-Methylumbelliferone is an indicator also used in the determination of nitric acid and in 4-MU-O-substrates for the kinetic investigation of enzyme activity.
Additional information
| Synonyms | 4-MU sodium salt, &beta,-Methylumbelliferone sodium salt, 7-Hydroxy-4-methylcoumarin sodium salt, Mendiaxon sodium salt, Cantabilin sodium salt |
|---|---|
| Purity | ≥97% (NMR) |
| Appearance | Light beige powder |
| CAS-Number | 5980-33-6 |
| Molecular Formula | C10H7O3 . Na |
| Molecular Weight | 198.15 |
| Identity | 1H-NMR |
| Melting Point | 90 – 92 °C |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Transportation | Not dangerous goods |
| References | (1) R.F. Chen, Anal. Lett. 1, 423 (1968), (2) T. Nakamura, et al., Biochem. Mol. Biol. Int. 43, 263 (1997), (3) I. Jones, et al., Mol. Gen. Metab. 108, S51 (2003), (4) I. Kakizaki, et al., J. Biol. Chem. 279, 33281 (2004), (5) S. Yoshihara, et al., FEBS Lett. 579, 2722 (2005), (6) R. Nakamura, et al., Cell Biol. Int. 31, 1022 (2007), (7) D. Vigetti, et al., Glycobiology 19, 537 (2009), (8) A. Kultti, et al., Exp. Cell Res. 315, 1914 (2009), (9) H. Urakawa, et al., Int. J. Cancer 130, 454 (2012), (10) J.A. Garcia-Vilas, et al., J. Agric. Food Chem. 61, 4063 (2013), (11) H. Zhi, et al., J. Spectrosc. 2013, ID 147128 (2013), (12) N. Nagy, et al., Front. Immunol. 6, 123 (2015) (Review), (13) H. Ban, et al., Anticancer Res. 35, 5231 (2015) |
| InChi | InChI=1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9,/h2-5,11H,1H3,/q,+1/p-1 |
| Quantity | 10 g, 25 g, 100 g, Bulk |
