Available from stock

4-Methylumbelliferyl palmitate

SKU: P0038

Categories: Fluorescent Detection, Fluorescent Detection

Synonyms: 4-MUP, 4-MU Palmitate, 4-Methyl-2-oxo-2H-chromen-7-yl palmitate, Palmitic acid 4-methylumbelliferyl ester; 17695-48-6
CAS-Number: C₂₆H₃₈O₄
Molecular Formula: 414.59
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥95% (NMR)
Appearance: White to off-white crystalline powder
Identity: 1H-NMR

Properties

Solvents: Soluble in DCM (10mg/ml), chloroform (20mg/ml) or DMF (10mg/m).
Melting Point: 77° C (lit.)
Fluorescence: λex 360 nm, λem 449 nm in 0.1 M phosphate pH 8.0

Shipping: AMBIENT
Short Term Storage: -20°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: (±)-Propranolol hydrochloride is a β-adrenergic receptor (β-AR) antagonist (Kds = 6.91, 0.832, and 117.49 nM for human β1-, β2- and β3-ARs, respectively). It also acts as a non-specific 5-HT1/5-HT2 serotonin receptor antagonist, reducing tranylcypromine/L-tryptophan-induced hyperactivity in rats. (±)-Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.
Smiles: O=C1OC2=CC(OC(CCCCCCCCCCCCCCC)=O)=CC=C2C(C)=C1
InChi Key: QKQVFFACWLFRRX-UHFFFAOYSA-N
References: (1) J.D. Fitzgerald & S.R. O'Donnell; Br. J. Pharmacol. 45, 207 (1972) , (2) B. Basil, et al.; Br. J. Pharmacol. 50, 323 (1974) , (3) D.W. Costain & A.R. Green; Br. J. Pharmacol. 64, 193 (1978) , (4) S.E. Litwin, et al.; Br. J. Pharmacol. 127, 1671 (1999) , (5) J.G. Baker; Br. J. Pharmacol. 144, 317 (2005) , (6) M.J. Wagner, et al.; J. Exp. Pharmacol. 10, 51 (2018)

(±)-Propranolol hydrochloride is a β-adrenergic receptor (β-AR) antagonist (Kds = 6.91, 0.832, and 117.49 nM for human β1-, β2- and β3-ARs, respectively). It also acts as a non-specific 5-HT1/5-HT2 serotonin receptor antagonist, reducing tranylcypromine/L-tryptophan-induced hyperactivity in rats. (±)-Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.

SKU: P0038 Categories: Fluorescent Detection, Fluorescent Detection

Additional information

Additional information

Synonyms	4-MUP, 4-MU Palmitate, 4-Methyl-2-oxo-2H-chromen-7-yl palmitate, Palmitic acid 4-methylumbelliferyl ester
Purity	≥95% (NMR)
Appearance	White to off-white crystalline powder
CAS-Number	17695-48-6
Molecular Formula	C26H38O4
Molecular Weight	414.59
Identity	1H-NMR
Solvents	Soluble in DCM (10mg/ml), chloroform (20mg/ml) or DMF (10mg/m).
Melting Point	77° C (lit.)
Fluorescence	λex 360 nm, λem 449 nm in 0.1 M phosphate pH 8.0
Smiles	O=C1OC2=CC(OC(CCCCCCCCCCCCCCC)=O)=CC=C2C(C)=C1
InChi Key	QKQVFFACWLFRRX-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	-20°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) J.D. Fitzgerald & S.R. O'Donnell; Br. J. Pharmacol. 45, 207 (1972), (2) B. Basil, et al.; Br. J. Pharmacol. 50, 323 (1974), (3) D.W. Costain & A.R. Green; Br. J. Pharmacol. 64, 193 (1978), (4) S.E. Litwin, et al.; Br. J. Pharmacol. 127, 1671 (1999), (5) J.G. Baker; Br. J. Pharmacol. 144, 317 (2005), (6) M.J. Wagner, et al.; J. Exp. Pharmacol. 10, 51 (2018)
Quantity	250 mg, 1 g, Bulk