Specifications
- Purity
- ≥95% (HPLC)
- Appearance
- Yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (25 mg/ml)
Category: API's & Intermediates
Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1? (68% inhibition of DYRK1? and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (?18% inhibition at 5 µM). Reported to exhibit antitumor activity in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20| 50 mg/kg via daily i.p.).
Synonyms | (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione, SMI-16a |
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Purity | ≥95% (HPLC) |
Appearance | Yellow powder |
CAS-Number | 587852-28-6 |
Molecular Formula | C13H13NO3S |
Molecular Weight | 263.3 |
Identity | 1H-NMR |
Solvents | DMSO (25 mg/ml) |
Smiles | CCCOC1=CC=C(/C=C2SC(NC2=O)=O)C=C1 |
InChi Key | GBWOSXZUTXXXQF-FLIBITNWSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) Z. Xia, et al.: J. Med. Chem. 52, 74 (2009), (2) Y.-W. Lin, et al.: Blood 115, 824 (2010), (3) Z. Beharry, et al.: PNAS 108, 528 (2011), (4) B. Cen, et al.: Cancer Res. 73, 3402 (2013), (5) B. Cen, et al.: Mol. Cell. Biol. 34, 2517 (2014), (6) M. Hiasa, et al.: Leukemia 29, 207 (2015) |
InChi | InChI=1S/C13H13NO3S/c1-2-7-17-10-5-3-9(4-6-10)8-11-12(15)14-13(16)18-11/h3-6,8H,2,7H2,1H3,(H,14,15,16)/b11-8- |
Quantity | 5 mg, 10 mg, 50 mg, Bulk |