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    5-Bromo-2'-deoxyuridine

    Available from stock

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      5-Bromo-2′-deoxyuridine

      SKU
      B0301

      Category: Non Fluorescent Detection & Chromogene Detection

      Synonyms
      5-BrdU , 5-Bromo-1-(2-deoxy-&beta , -D-ribofuranosyl)uracil , 5-Bromouracil deoxyriboside , BUdR , Bromodeoxyuridine , Broxuridine , NSC 38297
      59-14-3
      CAS-Number
      C9H11BrN2O5
      Molecular Formula
      307.10
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥99% (HPLC)
      Appearance
      White powder
      Identity
      1H-NMR

      Properties

      Solvents
      DMSO (30 mg/ml), DMF (30 mg/ml) or ethanol (25 mg/ml) or water (10 mg/ml).
      Melting Point
      191-194 °C (lit.)
      Shipping
      AMBIENT
      Short Term Storage
      +4°C
      Long Term Storage
      -20°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Hazard statements
      H340-H361
      Precautionary statements
      P201-P281-P308 + P313
      GHS Symbol
      GHS08
      Signal word
      Danger
      Transportation
      Not dangerous goods
      Description
      The synthetic nucleoside 5-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog used to label DNA and commonly used in the detection of proliferating cells in living tissues. It can be incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle. Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies with fluorescent tags to target the BrdU incorporation for detection via flow cytometry or fluorescence microscopy. Binding of the antibody requires denaturation of the DNA, usually by exposing the cells to acid or heat. BrdU is also used as a mutagen in genetic research. BrdU stimulates cellular differentiation and maturation in leukemia cell lines, while it inhibits differentiation of friend erythroleukemia cells. BrdU replaces Oct-4 in transcription factor-mediated reprogramming of somatic cells and can be used in small molecule cocktail to generate ciPSCs.
      Smiles
      O[C@H]1C[C@H](N2C=C(Br)C(NC2=O)=O)O[C@@H]1CO
      InChi Key
      WOVKYSAHUYNSMH-RRKCRQDMSA-N
      References
      (1) N. Kee, et al., J. Neurosci. Methods 115, 97 (2002) , (2) R.C. Leif, et al., Cytometry A 58, 45 (2004) (Review) , (3) P. Taupin, Brain Res. Rev. 53, 198 (2007) (Review) , (4) D.W. Stacey & M. Hitomi, Cytometry A 73, 270 (2008) , (5) B.L. Cavanagh, et al., Molecules 16, 7980 (2011) , (6) B. Lehner, et al., Cell Tissue Res. 345, 313 (2011) , (7) T. Konishi, et al., J. Radiat. Res. 52, 433 (2011) , (8) J.M. Barker, et al., PLoS One 8, e63692 (2013) , (9) Y. Long, et al., Cell Res. 25, 1171 (2015)
      InChi
      InChI=1S/C9H11BrN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

      The synthetic nucleoside 5-Bromo-2′-deoxyuridine (BrdU) is a thymidine analog used to label DNA and commonly used in the detection of proliferating cells in living tissues. It can be incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle. Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies with fluorescent tags to target the BrdU incorporation for detection via flow cytometry or fluorescence microscopy. Binding of the antibody requires denaturation of the DNA, usually by exposing the cells to acid or heat. BrdU is also used as a mutagen in genetic research. BrdU stimulates cellular differentiation and maturation in leukemia cell lines, while it inhibits differentiation of friend erythroleukemia cells. BrdU replaces Oct-4 in transcription factor-mediated reprogramming of somatic cells and can be used in small molecule cocktail to generate ciPSCs.

      SKU: B0301 Category: Non Fluorescent Detection & Chromogene Detection
      • Additional information

      Additional information

      Synonyms

      5-BrdU, 5-Bromo-1-(2-deoxy-&beta, -D-ribofuranosyl)uracil, 5-Bromouracil deoxyriboside, BUdR, Bromodeoxyuridine, Broxuridine, NSC 38297

      Purity

      ≥99% (HPLC)

      Appearance

      White powder

      CAS-Number

      59-14-3

      Molecular Formula

      C9H11BrN2O5

      Molecular Weight

      307.10

      Identity

      1H-NMR

      Solvents

      DMSO (30 mg/ml), DMF (30 mg/ml) or ethanol (25 mg/ml) or water (10 mg/ml).

      Melting Point

      191-194 °C (lit.)

      Smiles

      O[C@H]1C[C@H](N2C=C(Br)C(NC2=O)=O)O[C@@H]1CO

      InChi Key

      WOVKYSAHUYNSMH-RRKCRQDMSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Hazard statements

      H340-H361

      Precautionary statements

      P201-P281-P308 + P313

      GHS Symbol

      GHS08

      Signal word

      Danger

      Transportation

      Not dangerous goods

      References

      (1) N. Kee, et al., J. Neurosci. Methods 115, 97 (2002), (2) R.C. Leif, et al., Cytometry A 58, 45 (2004) (Review), (3) P. Taupin, Brain Res. Rev. 53, 198 (2007) (Review), (4) D.W. Stacey & M. Hitomi, Cytometry A 73, 270 (2008), (5) B.L. Cavanagh, et al., Molecules 16, 7980 (2011), (6) B. Lehner, et al., Cell Tissue Res. 345, 313 (2011), (7) T. Konishi, et al., J. Radiat. Res. 52, 433 (2011), (8) J.M. Barker, et al., PLoS One 8, e63692 (2013), (9) Y. Long, et al., Cell Res. 25, 1171 (2015)

      InChi

      InChI=1S/C9H11BrN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

      Quantity

      1 g, 5 g, Bulk

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