Specifications
- Purity
- ≥97% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White solid
Properties
- Melting Point
- 259-262 °C (lit.)
- Solvents
- DMF
Available from stock
6-(Dimethylamino)purine
- SKU
- D0318
Category: Metabolites
- Synonyms
- 6-DMAP , N6,N6-Dimethyladenine
- 938-55-6
- CAS-Number
- C7H9N5
- Molecular Formula
- 163.18
- Molecular Weight
- Short Term Storage
- +4°C
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Handling Advice
- Protect from light and moisture.
- Long Term Storage
- +4°C
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Description
- A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-alpha upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).
- InChi
- InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)
- References
- (1) H. Bredereck et al.: Berichte der Deutschen Chemischen Gesellschaft 73B, 1058-65 (1940) , (2) J. Vesely et al.: European Journal of Biochemistry 224(2), 771-86 (1994) , (3) P. Chesne et al.: Nature Biotechnology 20(4), 366-369 (2002)
- InChi Key
- BVIAOQMSVZHOJM-UHFFFAOYSA-N
- Smiles
- CN(C)C1=C2NC=NC2=NC=N1
A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-alpha upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).
Additional information
| Synonyms | 6-DMAP, N6,N6-Dimethyladenine |
|---|---|
| Purity | ≥97% (HPLC) |
| Appearance | White solid |
| CAS-Number | 938-55-6 |
| Molecular Formula | C7H9N5 |
| Molecular Weight | 163.18 |
| Identity | 1H-NMR |
| Solvents | DMF |
| Melting Point | 259-262 °C (lit.) |
| Smiles | CN(C)C1=C2NC=NC2=NC=N1 |
| InChi Key | BVIAOQMSVZHOJM-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Transportation | Not dangerous goods |
| References | (1) H. Bredereck et al.: Berichte der Deutschen Chemischen Gesellschaft 73B, 1058-65 (1940), (2) J. Vesely et al.: European Journal of Biochemistry 224(2), 771-86 (1994), (3) P. Chesne et al.: Nature Biotechnology 20(4), 366-369 (2002) |
| InChi | InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11) |
| Quantity | 1 g, Bulk |
