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    6-(Dimethylamino)purine

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      6-(Dimethylamino)purine

      SKU
      D0318

      Category: Metabolites

      Synonyms
      6-DMAP , N6,N6-Dimethyladenine
      938-55-6
      CAS-Number
      C7H9N5
      Molecular Formula
      163.18
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥97% (HPLC)
      Appearance
      White solid
      Identity
      1H-NMR

      Properties

      Solvents
      DMF
      Melting Point
      259-262 °C (lit.)

      Documentation

      Safety Data Sheet (SDS)
      CDX D0318 MSDS.pdf
      Shipping
      AMBIENT
      Short Term Storage
      +4°C
      Long Term Storage
      +4°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Transportation
      Not dangerous goods
      Description
      A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-alpha upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).
      Smiles
      CN(C)C1=C2NC=NC2=NC=N1
      InChi Key
      BVIAOQMSVZHOJM-UHFFFAOYSA-N
      References
      (1) H. Bredereck et al.: Berichte der Deutschen Chemischen Gesellschaft 73B, 1058-65 (1940) , (2) J. Vesely et al.: European Journal of Biochemistry 224(2), 771-86 (1994) , (3) P. Chesne et al.: Nature Biotechnology 20(4), 366-369 (2002)
      InChi
      InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)

      A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-alpha upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).

      SKU: D0318 Category: Metabolites
      • Additional information

      Additional information

      Synonyms

      6-DMAP, N6,N6-Dimethyladenine

      Purity

      ≥97% (HPLC)

      Appearance

      White solid

      CAS-Number

      938-55-6

      Molecular Formula

      C7H9N5

      Molecular Weight

      163.18

      Identity

      1H-NMR

      Solvents

      DMF

      Melting Point

      259-262 °C (lit.)

      Smiles

      CN(C)C1=C2NC=NC2=NC=N1

      InChi Key

      BVIAOQMSVZHOJM-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Transportation

      Not dangerous goods

      References

      (1) H. Bredereck et al.: Berichte der Deutschen Chemischen Gesellschaft 73B, 1058-65 (1940), (2) J. Vesely et al.: European Journal of Biochemistry 224(2), 771-86 (1994), (3) P. Chesne et al.: Nature Biotechnology 20(4), 366-369 (2002)

      InChi

      InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)

      Quantity

      1 g, Bulk

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