- Purity: ≥97% (HPLC)
- Appearance: White solid.
- CAS-Number: 938-55-6
- Molecular Formula: C7H9N5
- Molecular Weight: 163.18
- Identity: 1H-NMR
- Solvents: DMF
- Melting Point: 259-262 °C (lit.)
- Smiles: CN(C)C1=C2NC=NC2=NC=N1
- InChi: InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)
- InChi Key: BVIAOQMSVZHOJM-UHFFFAOYSA-N
Available from stock
6-(Dimethylamino)purine
SKU: D0318
- Shipping: AMBIENT
- Short Term Storage: +4°C
- Long Term Storage: +4°C
- Handling Advice: Protect from light and moisture.
- Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.
- Description: A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-alpha upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).
- References: (1) H. Bredereck et al.; Berichte der Deutschen Chemischen Gesellschaft 73B, 1058-65 (1940), (2) J. Vesely et al.; European Journal of Biochemistry 224(2), 771-86 (1994), (3) P. Chesne et al.; Nature Biotechnology 20(4), 366-369 (2002)
A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-alpha upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).
Additional information
| Identity | 1H-NMR |
|---|---|
| Molecular Formula | |
| CAS-Number | 938-55-6 |
| InChi | InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11) |
| Long Term Storage | +4°C |
| Quantity | 1 g, Bulk |
| Appearance | White solid. |
| InChi Key | BVIAOQMSVZHOJM-UHFFFAOYSA-N |
| Handling Advice | Protect from light and moisture. |
| Availability | 1 |
| Purity | |
| Shipping | AMBIENT |
| Pricetable | |
| Short Term Storage | +4°C |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Molecular Weight | |
| Smiles | CN(C)C1=C2NC=NC2=NC=N1 |
| Solvents | DMF |
| References | (1) H. Bredereck et al.; Berichte der Deutschen Chemischen Gesellschaft 73B, 1058-65 (1940), (2) J. Vesely et al.; European Journal of Biochemistry 224(2), 771-86 (1994), (3) P. Chesne et al.; Nature Biotechnology 20(4), 366-369 (2002) |
| Melting Point | 259-262 °C (lit.) |
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