Specifications
- Purity
- ≥97% (HPLC)
- Appearance
- Off-white to beige powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in chloroform or DMSO.
- Melting Point
- 143-146 °C
- Boiling Point
- 366 °C
- Density
- 1.319±0.06 g/cm3(Predicted)
Available from stock
7-Acetoxycoumarin
- SKU
- A0984
Category: Fluorescent Detection
- Synonyms
- 7AC, 7-Hydroxycoumarin acetate, Acetylumbelliferone, 2-Oxo-2H-chromen-7-yl acetate, Umbelliferone acetate
- 10387-49-2
- CAS-Number
- C11H8O4
- Molecular Formula
- 204.18
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H315, H319, H335
- Precautionary statements
- P261, P264, P271, P280, P302+P352, P305+P351+P338
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- 7-Acetoxycoumarin is a coumarin derivative widely used as a synthetic intermediate in organic and medicinal chemistry research. The acetoxy functional group provides a convenient site for chemical modification, making this compound a valuable building block for the synthesis of fluorescent probes, biologically active molecules, and specialty materials. 7-Acetoxycoumarin is commonly employed in studies involving coumarin-based compounds and their applications in chemical and pharmaceutical research. 7-Acetoxycoumarin also has been shown to have anti-inflammatory properties in cell-based studies. It significantly inhibits inflammatory responses in LPS-stimulated RAW 264.7 macrophage cells.
- Smiles
- O=C1OC2=C(C=CC(OC(C)=O)=C2)C=C1
- InChi Key
- MGZOXZPZHVOXQB-UHFFFAOYSA-N
- References
- (1) G.G. Guilbault, et al., Anal. Lett. 1, 551 (1968) , (2) E. Leroy, et al., Bioorg. Med. Chem. Lett. 13, 2105 (2003) , (3) F. Huo, et al., Analyst 138, 813 (2013) , (4) S. Yang, et al., Tetrahedr. 70, 8914 (2014) , (5) T. Park, et al., Molecules 25, 3124 (2020)
- InChi
- InChI=1S/C11H8O4/c1-7(12)14-9-4-2-8-3-5-11(13)15-10(8)6-9/h2-6H,1H3
7-Acetoxycoumarin is a coumarin derivative widely used as a synthetic intermediate in organic and medicinal chemistry research. The acetoxy functional group provides a convenient site for chemical modification, making this compound a valuable building block for the synthesis of fluorescent probes, biologically active molecules, and specialty materials. 7-Acetoxycoumarin is commonly employed in studies involving coumarin-based compounds and their applications in chemical and pharmaceutical research. 7-Acetoxycoumarin also has been shown to have anti-inflammatory properties in cell-based studies. It significantly inhibits inflammatory responses in LPS-stimulated RAW 264.7 macrophage cells.
Additional information
| Synonyms | 7AC, 7-Hydroxycoumarin acetate, Acetylumbelliferone, 2-Oxo-2H-chromen-7-yl acetate, Umbelliferone acetate |
|---|---|
| Purity | ≥97% (HPLC) |
| Appearance | Off-white to beige powder |
| CAS-Number | 10387-49-2 |
| Molecular Formula | C11H8O4 |
| Molecular Weight | 204.18 |
| Identity | 1H-NMR |
| Solvents | Soluble in chloroform or DMSO. |
| Melting Point | 143-146 °C |
| Boiling Point | 366 °C |
| Density | 1.319±0.06 g/cm3(Predicted) |
| Smiles | O=C1OC2=C(C=CC(OC(C)=O)=C2)C=C1 |
| InChi Key | MGZOXZPZHVOXQB-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H315, H319, H335 |
| Precautionary statements | P261, P264, P271, P280, P302+P352, P305+P351+P338 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) G.G. Guilbault, et al., Anal. Lett. 1, 551 (1968), (2) E. Leroy, et al., Bioorg. Med. Chem. Lett. 13, 2105 (2003), (3) F. Huo, et al., Analyst 138, 813 (2013), (4) S. Yang, et al., Tetrahedr. 70, 8914 (2014), (5) T. Park, et al., Molecules 25, 3124 (2020) |
| InChi | InChI=1S/C11H8O4/c1-7(12)14-9-4-2-8-3-5-11(13)15-10(8)6-9/h2-6H,1H3 |
| Quantity | 50 mg, 100 mg, Bulk |
