Specifications
- Purity
- ≥98% (NMR)
- Appearance
- Off-white to yellow solid
- Identity
- 1H-NMR
Properties
- Solvents
- chloroform or DMSO (100mM)
![7-[(Benzyloxy)methoxy]-4-(trifluoromethyl)-2H-chromen-2-one](https://www.chemodex.com/wp-content/uploads/2025/06/CDX-B0733.png)
Available from stock
7-[(Benzyloxy)methoxy]-4-(trifluoromethyl)-2H-chromen-2-one
- SKU
- B0733
Category: Fluorescent Detection
- Synonyms
- BOMFC
- 277309-33-8
- CAS-Number
- C18H13F3O4
- Molecular Formula
- 350.29
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P313-P337+P313-P362-P403+P233-P405-P501
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- BOMFC is a fluorescent probe used to study the activity of cytochrome P450 (CYP) enzymes, specifically insecticide metabolism and pyrethroid resistance. It serves as a sensitive substrate in fluorescence-based assays to assess the inhibitory action of potential synergists and to understand the interaction of pyrethroids like transfluthrin with CYP enzymes. BOMFC is a caged coumarin fluorophore that stays dark until cleaved by an enzyme. Once deprotected, it lights up blue, a classic "turn-on" fluorescent probe for enzyme activity. Once the protecting group is removed, the free hydroxycoumarin is formed. This molecule is now strongly fluorescent, Excitation: ~350–380 nm, Emission: ~450–480 nm (bright blue fluorescence).
- Smiles
- O=C1OC=2C=C(OCOCC=3C=CC=CC3)C=CC2C(=C1)C(F)(F)F
- InChi Key
- PNMPACFWCQYKAL-UHFFFAOYSA-N
- References
- (1) M. Nolden, et al., Curr. Res. Parasitol. Vector Borne Dis. 1, 100041 (2021) , (2) J. Haas, et al., Ecotoxicol. Environ. Safety 217, 112247 (2021) , (3) J. Haas, et al., Agricult. Sci. 119, e2205850119 (2022) , (4) J. Haas, et al., Pest Managm. Sci. 78, 965 (2022) , (5) D. Amezian, et al., Curr. Res. Insect Sci. 2, 100037 (2022) , (6) J. Haas, et al., Sci. Adv. 9, eadg0885 (2023) , (7) X. Xiao, et al., Ecotoxicol. Environ. Safety 268, 115719 (2023)
- InChi
- InChI=1S/C18H13F3O4/c19-18(20,21)15-9-17(22)25-16-8-13(6-7-14(15)16)24-11-23-10-12-4-2-1-3-5-12/h1-9H,10-11H2
BOMFC is a fluorescent probe used to study the activity of cytochrome P450 (CYP) enzymes, specifically insecticide metabolism and pyrethroid resistance. It serves as a sensitive substrate in fluorescence-based assays to assess the inhibitory action of potential synergists and to understand the interaction of pyrethroids like transfluthrin with CYP enzymes. BOMFC is a caged coumarin fluorophore that stays dark until cleaved by an enzyme. Once deprotected, it lights up blue, a classic “turn-on” fluorescent probe for enzyme activity. Once the protecting group is removed, the free hydroxycoumarin is formed. This molecule is now strongly fluorescent, Excitation: ~350–380 nm, Emission: ~450–480 nm (bright blue fluorescence).
Additional information
| Synonyms | BOMFC |
|---|---|
| Purity | ≥98% (NMR) |
| Appearance | Off-white to yellow solid |
| CAS-Number | 277309-33-8 |
| Molecular Formula | C18H13F3O4 |
| Molecular Weight | 350.29 |
| Identity | 1H-NMR |
| Solvents | chloroform or DMSO (100mM) |
| Smiles | O=C1OC=2C=C(OCOCC=3C=CC=CC3)C=CC2C(=C1)C(F)(F)F |
| InChi Key | PNMPACFWCQYKAL-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P313-P337+P313-P362-P403+P233-P405-P501 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) M. Nolden, et al., Curr. Res. Parasitol. Vector Borne Dis. 1, 100041 (2021), (2) J. Haas, et al., Ecotoxicol. Environ. Safety 217, 112247 (2021), (3) J. Haas, et al., Agricult. Sci. 119, e2205850119 (2022), (4) J. Haas, et al., Pest Managm. Sci. 78, 965 (2022), (5) D. Amezian, et al., Curr. Res. Insect Sci. 2, 100037 (2022), (6) J. Haas, et al., Sci. Adv. 9, eadg0885 (2023), (7) X. Xiao, et al., Ecotoxicol. Environ. Safety 268, 115719 (2023) |
| InChi | InChI=1S/C18H13F3O4/c19-18(20,21)15-9-17(22)25-16-8-13(6-7-14(15)16)24-11-23-10-12-4-2-1-3-5-12/h1-9H,10-11H2 |
| Quantity | 25 mg, 50 mg, Bulk |
