Specifications
- Purity
- ≥99% (HPLC)
- Appearance
- White crystalline powder
- Identity
- 1H-NMR
Properties
- Solvents
- water (slightly)
Downloads
- Safety Data Sheet
- CDX E0090 MSDS.pdf
Category: API's & Intermediates
Active metabolite enalapril. Nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Shown to improve cardiac preservation via bradykinin receptor and PKC without affecting ATP metabolism. Has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway. Increases PPARbeta/delta expression, without influence on PPARalpha and PPARgamma.
Synonyms | EAL, Enalapril acid, MK-422 |
---|---|
Purity | ≥99% (HPLC) |
Appearance | White crystalline powder |
CAS-Number | 76420-72-9 |
Molecular Formula | C18H24N2O5 |
Molecular Weight | 348.4 |
Identity | 1H-NMR |
Solvents | water (slightly) |
Smiles | C[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O |
InChi Key | LZFZMUMEGBBDTC-QEJZJMRPSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) D.J. DiPette, et al.: Clin. Pharmacol. Ther. 38, 199 (1985), (2) J.G. Kelly & K. O'Malley: Clin. Pharmacokinet. 19, 177 (1990), (3) X. Yang, et al.: J. Mol. Cell Cardiol. 28, 1445 (1996), (4) R. Lupi, et al.: Eur. J. Endocrinol. 154, 355 (2006), (5) M. Yu, et al.: Molecules 17, 2738 (2012), (6) H. Cernecka, et al.: Eur. J. Pharmacol. 714, 472 (2013) |
InChi | InChI=1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1 |
Quantity | 50 mg, 250 mg, Bulk |