Available from stock

Adenine

SKU: A0083

Category: Amino Acids, Peptides, Proteins

Synonyms: 6-Aminopurine , Vitamin B4; 73-24-5
CAS-Number: C₅H₅N₅
Molecular Formula: 135.13
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (NMR)
Appearance: White to off-white solid
Identity: 1H-NMR

Properties

Solvents: methanol or ethanol. Slightly water (~1 mg/ml).
Melting Point: >300 °C

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: RT
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at RT.

Hazard statements: H301
Precautionary statements: P301 + P310
GHS Symbol: GHS06
Signal word: Danger
RIDADR: UN2811
Transportation: Packing Group III

Description: Adenine is a purine nucleobase. It is part of DNA and RNA and is also a component of cofactors (NAD, FAD) and signaling molecules (cAMP). Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP. ATP is the energy currency of the cell and is required during cellular metabolism. Adenine is metabolized to 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease (CKD) with severe anemia in rats. Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds. Adenine is suitable for use as a media nucleic acid base supplement in cell culture or food/dietary research.
Smiles: NC1=NC=NC2=C1N=CN2
InChi Key: GFFGJBXGBJISGV-UHFFFAOYSA-N
References: (1) G. Nuki, Ann. Rheum. Dis. 42, 8 (1983) , (2) R. Shapiro, Orig. Life Evol. Biosph. 25, 83 (1995) , (3) J. Ross, J. Phys. Chem. B 110, 6987 (2006) , (4) T.E. Parry, Leuk. Res. 31, 1621 (2007) , (5) D. Thimm, et al., Acta Physiol. 213, 808 (2015) , (6) C. Wang, et al., Acta Pharm. Sin. B. 5, 431 (2015)
InChi: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)

Adenine is a purine nucleobase. It is part of DNA and RNA and is also a component of cofactors (NAD, FAD) and signaling molecules (cAMP). Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP. ATP is the energy currency of the cell and is required during cellular metabolism. Adenine is metabolized to 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease (CKD) with severe anemia in rats. Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds. Adenine is suitable for use as a media nucleic acid base supplement in cell culture or food/dietary research.

SKU: A0083 Category: Amino Acids, Peptides, Proteins

Additional information

Additional information

Synonyms	6-Aminopurine, Vitamin B4
Purity	≥98% (NMR)
Appearance	White to off-white solid
CAS-Number	73-24-5
Molecular Formula	C5H5N5
Molecular Weight	135.13
Identity	1H-NMR
Solvents	methanol or ethanol. Slightly water (~1 mg/ml).
Melting Point	>300 °C
Smiles	NC1=NC=NC2=C1N=CN2
InChi Key	GFFGJBXGBJISGV-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Hazard statements	H301
Precautionary statements	P301 + P310
GHS Symbol	GHS06
Signal word	Danger
RIDADR	UN2811
Transportation	Packing Group III
References	(1) G. Nuki, Ann. Rheum. Dis. 42, 8 (1983), (2) R. Shapiro, Orig. Life Evol. Biosph. 25, 83 (1995), (3) J. Ross, J. Phys. Chem. B 110, 6987 (2006), (4) T.E. Parry, Leuk. Res. 31, 1621 (2007), (5) D. Thimm, et al., Acta Physiol. 213, 808 (2015), (6) C. Wang, et al., Acta Pharm. Sin. B. 5, 431 (2015)
InChi	InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)
Quantity	25 g, 100 g, Bulk