AGD

SKU: D0169

Category: Fluorescent Detection

Synonyms: 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide; 1456890-74-6
CAS-Number: C₁₈H₂₄N₂O₆
Molecular Formula: 364.39
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥95% (NMR)
Identity: 1H-NMR
Appearance: Light yellow powder

Properties

Melting Point: 159-161°C
Solvents: DMSO, water

Short Term Storage: RT
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
Handling Advice: Protect from light and moisture.
Long Term Storage: -20°C
Shipping: AMBIENT

Transportation: Not dangerous goods

Description: Coumarin-based 'turn-off' fluorescent probe. Highly selective for ferrous ions (Fe(2+)) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe(2+) concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties. Spectral data, Excitation=430nm, Emission=480nm (HEPES, pH 7.4 at RT).
InChi: InChI=1S/C18H24N2O6/c1-3-20(4-2)13-6-5-12-7-14(17(25)26-15(12)8-13)16(24)19-18(9-21,10-22)11-23/h5-8,21-23H,3-4,9-11H2,1-2H3,(H,19,24)
References: O. Garcia-Beltran, et al., Eur. J. Med. Chem. 67, 60 (2013) , M.E. Aliaga, et al., New J. Chem. 39, 3084 (2015)
InChi Key: YGMFXQGOHXJXGN-UHFFFAOYSA-N
Smiles: O=C(C(C1=O)=CC2=C(O1)C=C(N(CC)CC)C=C2)NC(CO)(CO)CO

Coumarin-based ‘turn-off’ fluorescent probe. Highly selective for ferrous ions (Fe(2+)) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe(2+) concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties. Spectral data, Excitation=430nm, Emission=480nm (HEPES, pH 7.4 at RT).

SKU: D0169 Category: Fluorescent Detection

Additional information

Additional information

Synonyms	7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide
Purity	≥95% (NMR)
Appearance	Light yellow powder
CAS-Number	1456890-74-6
Molecular Formula	C18H24N2O6
Molecular Weight	364.39
Identity	1H-NMR
Solvents	DMSO, water
Melting Point	159-161°C
Smiles	O=C(C(C1=O)=CC2=C(O1)C=C(N(CC)CC)C=C2)NC(CO)(CO)CO
InChi Key	YGMFXQGOHXJXGN-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	O. Garcia-Beltran, et al., Eur. J. Med. Chem. 67, 60 (2013), M.E. Aliaga, et al., New J. Chem. 39, 3084 (2015)
InChi	InChI=1S/C18H24N2O6/c1-3-20(4-2)13-6-5-12-7-14(17(25)26-15(12)8-13)16(24)19-18(9-21,10-22)11-23/h5-8,21-23H,3-4,9-11H2,1-2H3,(H,19,24)
Quantity	100 mg, 250 mg, Bulk