Specifications
- Purity
- ≥95% (NMR)
- Appearance
- Light yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, water
- Melting Point
- 159-161°C
Available from stock
AGD
- SKU
- D0169
Categories: Fluorescent Detection, Fluorescent Detection
- Synonyms
- 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide
- 1456890-74-6
- CAS-Number
- C18H24N2O6
- Molecular Formula
- 364.39
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Transportation
- Not dangerous goods
- Description
- Coumarin-based 'turn-off' fluorescent probe. Highly selective for ferrous ions (Fe(2+)) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe(2+) concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties. Spectral data, Excitation=430nm, Emission=480nm (HEPES, pH 7.4 at RT).
- Smiles
- O=C(C(C1=O)=CC2=C(O1)C=C(N(CC)CC)C=C2)NC(CO)(CO)CO
- InChi Key
- YGMFXQGOHXJXGN-UHFFFAOYSA-N
- References
- O. Garcia-Beltran, et al., Eur. J. Med. Chem. 67, 60 (2013) , M.E. Aliaga, et al., New J. Chem. 39, 3084 (2015)
- InChi
- InChI=1S/C18H24N2O6/c1-3-20(4-2)13-6-5-12-7-14(17(25)26-15(12)8-13)16(24)19-18(9-21,10-22)11-23/h5-8,21-23H,3-4,9-11H2,1-2H3,(H,19,24)
Coumarin-based ‘turn-off’ fluorescent probe. Highly selective for ferrous ions (Fe(2+)) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe(2+) concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties. Spectral data, Excitation=430nm, Emission=480nm (HEPES, pH 7.4 at RT).
Additional information
| Synonyms | 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide |
|---|---|
| Purity | ≥95% (NMR) |
| Appearance | Light yellow powder |
| CAS-Number | 1456890-74-6 |
| Molecular Formula | C18H24N2O6 |
| Molecular Weight | 364.39 |
| Identity | 1H-NMR |
| Solvents | DMSO, water |
| Melting Point | 159-161°C |
| Smiles | O=C(C(C1=O)=CC2=C(O1)C=C(N(CC)CC)C=C2)NC(CO)(CO)CO |
| InChi Key | YGMFXQGOHXJXGN-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | O. Garcia-Beltran, et al., Eur. J. Med. Chem. 67, 60 (2013), M.E. Aliaga, et al., New J. Chem. 39, 3084 (2015) |
| InChi | InChI=1S/C18H24N2O6/c1-3-20(4-2)13-6-5-12-7-14(17(25)26-15(12)8-13)16(24)19-18(9-21,10-22)11-23/h5-8,21-23H,3-4,9-11H2,1-2H3,(H,19,24) |
| Quantity | 100 mg, 250 mg, Bulk |
