Available from stock

Aloin

SKU: A0527

Category: Phytochemicals

Synonyms: 1,8-Dihydroxy-10-(β-D-glucopyranosyl)-3-(hydroxymethyl)-9(10H)-anthracenone , Aloin A , Barbaloin A , NSC 407305; 1415-73-2
CAS-Number: C₂₁H₂₂O₉
Molecular Formula: 418.39
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: Yellow Powder
Identity: 1H-NMR

Properties

Solvents: DMSO, methanol (both 50 mg/ml)
Melting Point: 148-149° C

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Transportation: Not dangerous goods

Description: Aloin is a naturally occurring substance found in various Aloe plant species. Aloin was originally used as a laxative in the treatment of constipation. Aloin is a chemopreventive and antineoplastic agent. It is a cytotoxic against cancer cells. As a anticancer agent it inhibits Topoisomerase II alpha, induces apoptosis, targets High Mobility Group Box 1 (HMGB1) and inhibits angiogenesis. It has been shown to be a potent skin depigmenting agent, enhancing melanogenesis. It has been described as a tyroniase inhibitor. It regulates transglutaminase activity. In addition Aloin is an anti-inflammatory agent, inhibiting the NF-?B pathway, antitrypanosomal, iron chelating and microbiota modulating compound.
Smiles: OC1=C2C([C@@]([C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)([H])C(C=C(CO)C=C4O)=C4C2=O)=CC=C1
InChi Key: AFHJQYHRLPMKHU-OSYMLPPYSA-N
References: (1) C. Tan, et al., Chin. Med. J. 115, 1859 (2002) , (2) A.Y. Esmat, et al., Cancer Biol. Ther. 5, 97 (2006) , (3) A. Niciforovic, et al., Cancer Biol. Ther. 6, 1200 (2007) , (4) E.J. Buenz, Toxicol. In Vitro 22, 422 (2008) , (5) A.H.A. Farooqi, et al., J. Med. Aro. Plant. Sci. 31, 159 (2009) , (6) M.Y. Park, et al., Biosci. Biotechnol. Biochem. 73, 828 (2009) , (7) S. Ravi, et al., J. Exp. Sci. 2, 10 (2011) , (8) S. Hazrati, et al., J. Med. Plants. Res. 6, 1834 (2012) , (9) S.A. Ali, et al., Planta Med. 78, 767 (2012) , (10) Q. Pan, et al., Cancer Cell Int. 13, 69 (2013) , (11) Y. Tewabe, et al., BMC Vet. Res. 10, 61 (2014) , (12) A.Y. Esmat, et al., Pharm. Biol. 53, 138 (2015) , (13) Y. Pengjam, et al., Phytomedicine 23, 417 (2016) , (14) M.D. Boudreau, et al., Toxicol. Sci. 158, 302 (2017) , (15) X. Luo, et al., Molecules 23, E517 (2018) , (16) H. Tao, et al., Drug Des. Devel. Ther. 13, 1221 (2019)

Aloin is a naturally occurring substance found in various Aloe plant species. Aloin was originally used as a laxative in the treatment of constipation. Aloin is a chemopreventive and antineoplastic agent. It is a cytotoxic against cancer cells. As a anticancer agent it inhibits Topoisomerase II alpha, induces apoptosis, targets High Mobility Group Box 1 (HMGB1) and inhibits angiogenesis. It has been shown to be a potent skin depigmenting agent, enhancing melanogenesis. It has been described as a tyroniase inhibitor. It regulates transglutaminase activity. In addition Aloin is an anti-inflammatory agent, inhibiting the NF-?B pathway, antitrypanosomal, iron chelating and microbiota modulating compound.

SKU: A0527 Category: Phytochemicals

Additional information

Additional information

Synonyms	1,8-Dihydroxy-10-(β-D-glucopyranosyl)-3-(hydroxymethyl)-9(10H)-anthracenone, Aloin A, Barbaloin A, NSC 407305
Purity	≥98% (HPLC)
Appearance	Yellow Powder
CAS-Number	1415-73-2
Molecular Formula	C21H22O9
Molecular Weight	418.39
Identity	1H-NMR
Solvents	DMSO, methanol (both 50 mg/ml)
Melting Point	148-149° C
Smiles	OC1=C2C([C@@]([C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)([H])C(C=C(CO)C=C4O)=C4C2=O)=CC=C1
InChi Key	AFHJQYHRLPMKHU-OSYMLPPYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Transportation	Not dangerous goods
References	(1) C. Tan, et al., Chin. Med. J. 115, 1859 (2002), (2) A.Y. Esmat, et al., Cancer Biol. Ther. 5, 97 (2006), (3) A. Niciforovic, et al., Cancer Biol. Ther. 6, 1200 (2007), (4) E.J. Buenz, Toxicol. In Vitro 22, 422 (2008), (5) A.H.A. Farooqi, et al., J. Med. Aro. Plant. Sci. 31, 159 (2009), (6) M.Y. Park, et al., Biosci. Biotechnol. Biochem. 73, 828 (2009), (7) S. Ravi, et al., J. Exp. Sci. 2, 10 (2011), (8) S. Hazrati, et al., J. Med. Plants. Res. 6, 1834 (2012), (9) S.A. Ali, et al., Planta Med. 78, 767 (2012), (10) Q. Pan, et al., Cancer Cell Int. 13, 69 (2013), (11) Y. Tewabe, et al., BMC Vet. Res. 10, 61 (2014), (12) A.Y. Esmat, et al., Pharm. Biol. 53, 138 (2015), (13) Y. Pengjam, et al., Phytomedicine 23, 417 (2016), (14) M.D. Boudreau, et al., Toxicol. Sci. 158, 302 (2017), (15) X. Luo, et al., Molecules 23, E517 (2018), (16) H. Tao, et al., Drug Des. Devel. Ther. 13, 1221 (2019)
Quantity	50 mg, 100 mg, Bulk