Available from stock

Amiodarone hydrochloride

SKU: A0797

Category: Building Blocks, Intermediates, Reagents

Synonyms: Cordarone, Pacerone, Nexterone, 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone hydrochloride, SKF 33134A, L 3428-Labaz, NSC 85442; 19774-82-4
CAS-Number: C₂₅H₂₉I₂NO₃ · HCl
Molecular Formula: 681.77
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (TLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: Soluble in DMF (10 mg/ml), DMSO (10 mg/ml), ethanol (5 mg/ml) or chloroform.
Melting Point: 154-158°C

Documentation

Safety Data Sheet (SDS): CDX A0797 SDS_Vs1.1.pdf

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H315,H319,H335,H351,H361fd,H362,H410
Precautionary statements: P260 - P263 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
GHS Symbol: GHS07+GHS08+GHS09
Signal word: Warning
RIDADR: UN3077
Transportation: Packing Group III

Description: Amiodarone hydrochloride is a non-selective ion channel blocker (potassium, sodium and calcium channels). Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2. In addition, amiodarone binds with high affinity to the ?-1 opioid receptor, 3-?-hydroxysteroid ?8?7 isomerase, and C-8 sterol isomerase and inhibits human thyroid hormone receptors ? and ?. It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations. Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Recently, this K+ efflux inhibitor has been used to block the colocalisation of miniNLRP3 and ASC in red blood cells (RBCs), in a new process involving miniNLRP3 and RBC lysis, called spectosis.
Smiles: IC1=C(OCCN(CC)CC)C(I)=CC(C(C2=C(CCCC)OC3=C2C=CC=C3)=O)=C1.Cl
InChi Key: ITPDYQOUSLNIHG-UHFFFAOYSA-N
References: (1) R.A. Haworth, et al., Circ. Res. 65, 1157 (1989) , (2) T.J. Campbell & K.M. Williams, Br. J. Clin. Pharmacol. 46, 307 (1998) , (3) D.S. Holmes, et al., J. Cardiovasc. Electrophysiol. 11, 1152 (2000) , (4) B. Carlsson, et al., J. Med. Chem. 45, 623 (2002) , (5) T.M. Polasek, et al., J. Pharmacol. Exp. Ther. 311, 996 (2004) , (6) C. Laggner, et al., J. Med. Chem. 48, 4754 (2005) , (7) N. Sinha & S. Sen, Eur. J. Med. Chem. 46, 618 (2011) , (8) J. Weng, et al., Biomed. Pharmacother. 115, 108889 (2019) , (9) H. Liang, et al., Curr. Mol. Med. 25, 69 (2025) , (10) Y. Chen, et al., Cell 188, 3013 (2025)
InChi: InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3,/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3,1H

Amiodarone hydrochloride is a non-selective ion channel blocker (potassium, sodium and calcium channels). Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2. In addition, amiodarone binds with high affinity to the ?-1 opioid receptor, 3-?-hydroxysteroid ?8?7 isomerase, and C-8 sterol isomerase and inhibits human thyroid hormone receptors ? and ?. It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations. Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Recently, this K+ efflux inhibitor has been used to block the colocalisation of miniNLRP3 and ASC in red blood cells (RBCs), in a new process involving miniNLRP3 and RBC lysis, called spectosis.

SKU: A0797 Category: Building Blocks, Intermediates, Reagents

Additional information

Additional information

Synonyms	Cordarone, Pacerone, Nexterone, 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone hydrochloride, SKF 33134A, L 3428-Labaz, NSC 85442
Purity	≥98% (TLC)
Appearance	White to off-white powder
CAS-Number	19774-82-4
Molecular Formula	C25H29I2NO3 · HCl
Molecular Weight	681.77
Identity	1H-NMR
Solvents	Soluble in DMF (10 mg/ml), DMSO (10 mg/ml), ethanol (5 mg/ml) or chloroform.
Melting Point	154-158°C
Smiles	IC1=C(OCCN(CC)CC)C(I)=CC(C(C2=C(CCCC)OC3=C2C=CC=C3)=O)=C1.Cl
InChi Key	ITPDYQOUSLNIHG-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H315,H319,H335,H351,H361fd,H362,H410
Precautionary statements	P260 – P263 – P273 – P302 + P352 – P305 + P351 + P338 – P308 + P313
GHS Symbol	GHS07+GHS08+GHS09
Signal word	Warning
RIDADR	UN3077
Transportation	Packing Group III
References	(1) R.A. Haworth, et al., Circ. Res. 65, 1157 (1989), (2) T.J. Campbell & K.M. Williams, Br. J. Clin. Pharmacol. 46, 307 (1998), (3) D.S. Holmes, et al., J. Cardiovasc. Electrophysiol. 11, 1152 (2000), (4) B. Carlsson, et al., J. Med. Chem. 45, 623 (2002), (5) T.M. Polasek, et al., J. Pharmacol. Exp. Ther. 311, 996 (2004), (6) C. Laggner, et al., J. Med. Chem. 48, 4754 (2005), (7) N. Sinha & S. Sen, Eur. J. Med. Chem. 46, 618 (2011), (8) J. Weng, et al., Biomed. Pharmacother. 115, 108889 (2019), (9) H. Liang, et al., Curr. Mol. Med. 25, 69 (2025), (10) Y. Chen, et al., Cell 188, 3013 (2025)
InChi	InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3,/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3,1H
Quantity	1 g, 5 g, Bulk