Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (40 mg/ml), chloroform, ethanol, methanol or water (5 mg/ml)
Available from stock
Amlodipine besylate
- SKU
- A0569
Categories:
- Synonyms
- 2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate , Norvasc , Amdepin , Amdipin , Amlodin
- 111470-99-6
- CAS-Number
- C20H25ClN2O5 · C6H5SO3H
- Molecular Formula
- 567.05
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- -20°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H302
- Precautionary statements
- P301 + P312 + P330
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- Amlodipine is a long acting calcium channel antagonist that selectively inhibits calcium ion influx across cell membranes. It acts at the voltage gated calcium channel of the CaV1 or L-type class. It targets L-type calcium channels in muscle cells and N-type calcium channels in the central nervous system which are involved in nociceptive signalling and pain perception. Amlodipine is also an antihypertensive agent that inhibits calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells. This causes vasodilation and a reduction in peripheral vascular resistance, thus lowering blood pressure. Its effects on cardiac muscle also prevent excessive constriction in the coronary arteries. Amlodipine has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.
- Smiles
- CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
- InChi Key
- ZPBWCRDSRKPIDG-UHFFFAOYSA-N
- References
- (1) J.E. Arrowsmith, et al., J. Med. Chem. 29, 1696 (1986) , (2) R.A. Burges, et al., J. Cardiovasc. Pharmacol. 9, 110 (1987) , (3) G.A. Clavijo, et al., Am. J. Hosp. Pharm. 51, 59 (1994) , (4) J. Yoshida, et al., Eur. J. Pharmacol. 472, 23 (2003) , (5) R.P. Mason, et al., Arterioscler. Thromb. Vasc. Biol. 23, 2155 (2003) , (6) H. Toba, et al., Hypertens. Res. 28, 689 (2005)
Amlodipine is a long acting calcium channel antagonist that selectively inhibits calcium ion influx across cell membranes. It acts at the voltage gated calcium channel of the CaV1 or L-type class. It targets L-type calcium channels in muscle cells and N-type calcium channels in the central nervous system which are involved in nociceptive signalling and pain perception. Amlodipine is also an antihypertensive agent that inhibits calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells. This causes vasodilation and a reduction in peripheral vascular resistance, thus lowering blood pressure. Its effects on cardiac muscle also prevent excessive constriction in the coronary arteries. Amlodipine has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.
Additional information
| Synonyms | 2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate, Norvasc, Amdepin, Amdipin, Amlodin |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 111470-99-6 |
| Molecular Formula | C20H25ClN2O5 · C6H5SO3H |
| Molecular Weight | 567.05 |
| Identity | 1H-NMR |
| Solvents | DMSO (40 mg/ml), chloroform, ethanol, methanol or water (5 mg/ml) |
| Smiles | CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN |
| InChi Key | ZPBWCRDSRKPIDG-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) J.E. Arrowsmith, et al., J. Med. Chem. 29, 1696 (1986), (2) R.A. Burges, et al., J. Cardiovasc. Pharmacol. 9, 110 (1987), (3) G.A. Clavijo, et al., Am. J. Hosp. Pharm. 51, 59 (1994), (4) J. Yoshida, et al., Eur. J. Pharmacol. 472, 23 (2003), (5) R.P. Mason, et al., Arterioscler. Thromb. Vasc. Biol. 23, 2155 (2003), (6) H. Toba, et al., Hypertens. Res. 28, 689 (2005) |
| Quantity | 10 mg, 50 mg, Bulk |
