Available from stock

Apigenin

SKU: A0438

Category: Phytochemicals

Synonyms: Chamomile , Flavone , NSC 83244 , Versulin , 4',5,7-Trihydroxyflavone , 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone; 520-36-5
CAS-Number: C₁₅H₁₀O₅
Molecular Formula: 270.24
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥95% (HPLC)
Appearance: Yellow to brown powder
Identity: 1H-NMR

Properties

Solvents: DMSO (10mg/ml), DMF (20 mg/ml)
Melting Point: >300 °C (lit.)

Documentation

Safety Data Sheet (SDS): CDX A0438 SDS_Vs1.1.pdf

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Apigenin is an antioxidant plant flavonoid with anti-inflammatory, angiogenic, neuroprotective and anticancer properties. It may induce apoptosis and inhibit proliferation of tumor cells by arresting the cell cycle at the G2/M phase. Inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Also known to be a MAP kinase inhibitor and a selectively inhibitor of casein kinase 2 (CK2). It is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression.
Smiles: OC1=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=CC(O)=C1
InChi Key: KZNIFHPLKGYRTM-UHFFFAOYSA-N
References: (1) Y.C. Liang, et al., Carcinogenesis 20, 1945 (1999) , (2) D.H. Song, et al., J. Biol. Chem. 275, 23790 (2000) , (3) J. Shen, et al., J. Immunol. 167, 4919 (2001) , (4) G.M. Raso, et al., Life Sci. 68, 921 (2001) , (5) M. Yamada, et al., PNAS 102, 7736 (2005) , (6) M.B. Ujiki, et al., Mol. Cancer 5, 76 (2006) , (7) J. Fang, et al., Carcinogenesis 28, 858 (2006) , (8) X. Yan, et al., Cell Biosci. 7, 50 (2017) (Review) , (9) S.F. Nabavi, et al., Pharmacol. Res. 128, 359 (2018) (Review) , (10) J. Madunic, et al., Cancer Lett. 413, 11 (2018) (Review)

Apigenin is an antioxidant plant flavonoid with anti-inflammatory, angiogenic, neuroprotective and anticancer properties. It may induce apoptosis and inhibit proliferation of tumor cells by arresting the cell cycle at the G2/M phase. Inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Also known to be a MAP kinase inhibitor and a selectively inhibitor of casein kinase 2 (CK2). It is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression.

SKU: A0438 Category: Phytochemicals

Additional information

Additional information

Synonyms	Chamomile, Flavone, NSC 83244, Versulin, 4',5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
Purity	≥95% (HPLC)
Appearance	Yellow to brown powder
CAS-Number	520-36-5
Molecular Formula	C15H10O5
Molecular Weight	270.24
Identity	1H-NMR
Solvents	DMSO (10mg/ml), DMF (20 mg/ml)
Melting Point	>300 °C (lit.)
Smiles	OC1=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=CC(O)=C1
InChi Key	KZNIFHPLKGYRTM-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) Y.C. Liang, et al., Carcinogenesis 20, 1945 (1999), (2) D.H. Song, et al., J. Biol. Chem. 275, 23790 (2000), (3) J. Shen, et al., J. Immunol. 167, 4919 (2001), (4) G.M. Raso, et al., Life Sci. 68, 921 (2001), (5) M. Yamada, et al., PNAS 102, 7736 (2005), (6) M.B. Ujiki, et al., Mol. Cancer 5, 76 (2006), (7) J. Fang, et al., Carcinogenesis 28, 858 (2006), (8) X. Yan, et al., Cell Biosci. 7, 50 (2017) (Review), (9) S.F. Nabavi, et al., Pharmacol. Res. 128, 359 (2018) (Review), (10) J. Madunic, et al., Cancer Lett. 413, 11 (2018) (Review)
Quantity	25 mg, 100 mg, Bulk