Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in DMSO (5 mg/ml) or chloroform.
Documentation
- Safety Data Sheet (SDS)
- CDX A0692 SDS_Vs1.1.pdf
Available from stock
Apixaban
- SKU
- A0692
Category: API's & Intermediates
- Synonyms
- 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide, BMS 562247-01
- 503612-47-3
- CAS-Number
- C25H25N5O4
- Molecular Formula
- 459.50
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Transportation
- Not dangerous goods
- Description
- "Apixaban is an orally active, active site-targeting, highly potent and selective inhibitor of factor Xa (FXa), an essential component of the coagulation cascade. It functions by selectively binding to both free and clot-bound factor Xa, thereby inhibiting its activity and preventing the conversion of prothrombin to thrombin. This inhibition ultimately leads to the prevention of thrombin formation and subsequent blood clot formation. Apixaban achieves this by targeting the active site of factor Xa, interfering with its ability to interact with its substrates. By doing so, it effectively disrupts the coagulation process and impedes the formation of fibrin clots. This mechanism of action makes apixaban a promising candidate for research and development aimed at understanding and manipulating the coagulation cascade. In vivo, apixaban has antithrombotic efficacy in vivo in a rabbit model of venous thrombosis. Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.
- Smiles
- O=C1C2=C(C(C(N)=O)=NN2C3=CC=C(OC)C=C3)CCN1C4=CC=C(N5CCCCC5=O)C=C4
- InChi Key
- QNZCBYKSOIHPEH-UHFFFAOYSA-N
- References
- at understanding and manipulating the coagulation cascade. In vivo, apixaban has antithrombotic efficacy in vivo in a rabbit model of venous thrombosis. Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.
“Apixaban is an orally active, active site-targeting, highly potent and selective inhibitor of factor Xa (FXa), an essential component of the coagulation cascade. It functions by selectively binding to both free and clot-bound factor Xa, thereby inhibiting its activity and preventing the conversion of prothrombin to thrombin. This inhibition ultimately leads to the prevention of thrombin formation and subsequent blood clot formation. Apixaban achieves this by targeting the active site of factor Xa, interfering with its ability to interact with its substrates. By doing so, it effectively disrupts the coagulation process and impedes the formation of fibrin clots. This mechanism of action makes apixaban a promising candidate for research and development aimed at understanding and manipulating the coagulation cascade. In vivo, apixaban has antithrombotic efficacy in vivo in a rabbit model of venous thrombosis. Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.
Additional information
| Synonyms | 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide, BMS 562247-01 |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 503612-47-3 |
| Molecular Formula | C25H25N5O4 |
| Molecular Weight | 459.50 |
| Identity | 1H-NMR |
| Solvents | Soluble in DMSO (5 mg/ml) or chloroform. |
| Smiles | O=C1C2=C(C(C(N)=O)=NN2C3=CC=C(OC)C=C3)CCN1C4=CC=C(N5CCCCC5=O)C=C4 |
| InChi Key | QNZCBYKSOIHPEH-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Transportation | Not dangerous goods |
| References | at understanding and manipulating the coagulation cascade. In vivo, apixaban has antithrombotic efficacy in vivo in a rabbit model of venous thrombosis. Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation. |
| Quantity | 10 mg, 50 mg, Bulk |
