Specifications
- Purity
- ≥95%
- Appearance
- Light yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (30 mg/ml), DMF (30 mg/ml) or ethanol (10 mg/ml).
- Melting Point
- 116 °C
Available from stock
Ascorbic acid 6-palmitate
- SKU
- A0534
Category: Vitamins
- Synonyms
- AA6P , 6-O-Palmitoyl-L-ascorbic acid , Ascorbylpalmitic Acid , L-Ascorbic acid 6-hexadecanoate , L-Ascorbyl palmitate , Ascorbic acid 6-palmitate , NSC 402451
- 137-66-6
- CAS-Number
- C22H38O7
- Molecular Formula
- 414.53
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- Ascorbic acid 6-palmitate is fat-soluble form of vitamin C formed from ascorbic acid and palmitic acid and not naturally found in food sources. It is used as a source of vitamin C and as food preservative (E number E304) for stabilization fats and oils, reducing the rate of. It is also used as preservative in pharmaceuticals and cosmetics. Ascorbic acid 6-palmitate has antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays and inhibits lipid peroxidation. It has been shown that despite its antioxidant properties, ascorbic acid 6-palmitate promotes LPO, JNK activation and cytotoxicity following UVB irradiation. Ascorbic acid 6-palmitate effectively inhibited anthrax cytotoxic protease and blocks proteolytic activities of host furin, cathepsin B and caspases that mediate toxin's lethality in cells. It is broad-spectrum and reduces cellular sensitivity to other bacterial toxins that require the same host proteases.
- Smiles
- OC1=C(O)C(O[C@@]1([H])[C@H](COC(CCCCCCCCCCCCCCC)=O)O)=O
- InChi Key
- QAQJMLQRFWZOBN-UWJYYQICSA-N
- References
- (1) W.M. Cort, J. Am. Oil Chem. Soc. 51, 321 (1974) , (2) R.C. Smart & C.L. Crawford, Am. J. Clin. Nutr. 54, 1266S (1991) , (3) H. Chen & A.L. Tappel, Free Radic. Res. 22, 177 (1995) , (4) N. Perricone, et al., BBRC 262, 661 (1999) , (5) O. Yilmaz, et al., J. Cell Biochem. 86, 530 (2002) , (6) A. Meves, et al., J. Invest. Dermatol. 119, 1103 (2002) , (7) K.M. Lee, et al., Mutat. Res. 660, 51 (2009) , (8) S.K. Karmee, Appl. Microbiol. Biotechnol. 81, 1013 (2009) (Review) , (9) R. Mohamed, et al., J. Pharm. Pharmacol. 66, 769 (2014) , (10) L. Zilbermintz, et al., Sci. Rep. 6, 34846 (2016)
- InChi
- InChI=1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21-/m0/s1
Ascorbic acid 6-palmitate is fat-soluble form of vitamin C formed from ascorbic acid and palmitic acid and not naturally found in food sources. It is used as a source of vitamin C and as food preservative (E number E304) for stabilization fats and oils, reducing the rate of. It is also used as preservative in pharmaceuticals and cosmetics. Ascorbic acid 6-palmitate has antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays and inhibits lipid peroxidation. It has been shown that despite its antioxidant properties, ascorbic acid 6-palmitate promotes LPO, JNK activation and cytotoxicity following UVB irradiation. Ascorbic acid 6-palmitate effectively inhibited anthrax cytotoxic protease and blocks proteolytic activities of host furin, cathepsin B and caspases that mediate toxin’s lethality in cells. It is broad-spectrum and reduces cellular sensitivity to other bacterial toxins that require the same host proteases.
Additional information
| Synonyms | AA6P, 6-O-Palmitoyl-L-ascorbic acid, Ascorbylpalmitic Acid, L-Ascorbic acid 6-hexadecanoate, L-Ascorbyl palmitate, Ascorbic acid 6-palmitate, NSC 402451 |
|---|---|
| Purity | ≥95% |
| Appearance | Light yellow powder |
| CAS-Number | 137-66-6 |
| Molecular Formula | C22H38O7 |
| Molecular Weight | 414.53 |
| Identity | 1H-NMR |
| Solvents | DMSO (30 mg/ml), DMF (30 mg/ml) or ethanol (10 mg/ml). |
| Melting Point | 116 °C |
| Smiles | OC1=C(O)C(O[C@@]1([H])[C@H](COC(CCCCCCCCCCCCCCC)=O)O)=O |
| InChi Key | QAQJMLQRFWZOBN-UWJYYQICSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | (1) W.M. Cort, J. Am. Oil Chem. Soc. 51, 321 (1974), (2) R.C. Smart & C.L. Crawford, Am. J. Clin. Nutr. 54, 1266S (1991), (3) H. Chen & A.L. Tappel, Free Radic. Res. 22, 177 (1995), (4) N. Perricone, et al., BBRC 262, 661 (1999), (5) O. Yilmaz, et al., J. Cell Biochem. 86, 530 (2002), (6) A. Meves, et al., J. Invest. Dermatol. 119, 1103 (2002), (7) K.M. Lee, et al., Mutat. Res. 660, 51 (2009), (8) S.K. Karmee, Appl. Microbiol. Biotechnol. 81, 1013 (2009) (Review), (9) R. Mohamed, et al., J. Pharm. Pharmacol. 66, 769 (2014), (10) L. Zilbermintz, et al., Sci. Rep. 6, 34846 (2016) |
| InChi | InChI=1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21-/m0/s1 |
| Quantity | 25 g, 100 g, Bulk |
