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beta-Nicotinamide adenine dinucleotide phosphate sodium salt hydrate

SKU: N0151

Category: Metabolites

Synonyms: Coenzyme II , β-NADP , NADP+ , TPN , Triphosphopyridine nucleotide sodium salt hydrate; 698999-85-8
CAS-Number: C₂₁H₂₇N₇NaO₁₇P₃ . xH₂O
Molecular Formula: 765.39 (anhydrous)
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: water (30 mg/ml)

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Hazard statements: H319
Precautionary statements: P280-P305 + P351 + P338-P337 + P313
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate. It is a cofactor used in anabolic reactions, such as the Calvin cycle, lipid syntheses and nucleic acid syntheses, which require NADPH as a reducing agent. It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynthesized from NAD+ by NAD kinase, with ATP as the phosphoryl donor. NADP+ might be useful for immunometabolism research.
Smiles: O[C@H]1[C@@H](OP(O)(O)=O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP([O-])(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)=O.[Na+]
InChi Key: JNUMDLCHLVUHFS-QYZPTAICSA-M
References: (1) F. Shi, et al., Acta Biochim. Biophys. Sin. 41, 352 (2009) , (2) J.B. Jackson, BBA 1817, 1839 (2012) , (3) M. Nakamura, et al., Circ. Res. 111, 604 (2012) , (4) P.J. Kilfoil, et al., Circ. Res. 112, 721 (2013) , (5) M. Ziegler, FEBS J. 272, 4561 (2014) , (6) R. Ramalho, et al., Sem. Immunopathol. 42, 279 (2020)
InChi: InChI=1S/C21H28N7O17P3.Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32,/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39),/q,+1/p-1/t10-,11-,13-,14-,15-,16-,20-,21-,/m1./s1

NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate. It is a cofactor used in anabolic reactions, such as the Calvin cycle, lipid syntheses and nucleic acid syntheses, which require NADPH as a reducing agent. It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynthesized from NAD+ by NAD kinase, with ATP as the phosphoryl donor. NADP+ might be useful for immunometabolism research.

SKU: N0151 Category: Metabolites

Additional information

Additional information

Synonyms	Coenzyme II, β-NADP, NADP+, TPN, Triphosphopyridine nucleotide sodium salt hydrate
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	698999-85-8
Molecular Formula	C21H27N7NaO17P3 . xH2O
Molecular Weight	765.39 (anhydrous)
Identity	1H-NMR
Solvents	water (30 mg/ml)
Smiles	O[C@H]1[C@@H](OP(O)(O)=O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP([O-])(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)=O.[Na+]
InChi Key	JNUMDLCHLVUHFS-QYZPTAICSA-M
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements	H319
Precautionary statements	P280-P305 + P351 + P338-P337 + P313
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) F. Shi, et al., Acta Biochim. Biophys. Sin. 41, 352 (2009), (2) J.B. Jackson, BBA 1817, 1839 (2012), (3) M. Nakamura, et al., Circ. Res. 111, 604 (2012), (4) P.J. Kilfoil, et al., Circ. Res. 112, 721 (2013), (5) M. Ziegler, FEBS J. 272, 4561 (2014), (6) R. Ramalho, et al., Sem. Immunopathol. 42, 279 (2020)
InChi	InChI=1S/C21H28N7O17P3.Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32,/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39),/q,+1/p-1/t10-,11-,13-,14-,15-,16-,20-,21-,/m1./s1
Quantity	500 mg, 1 g, Bulk