Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to light yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- ethanol (20 mg/ml) or DMSO (10 mg/ml).
- Melting Point
- 225 °C (decomp.)
- Boiling Point
- 416.8 °C (predicted)
- Density
- 1.478 g/cm3 (predicted)
Category: Phytochemicals
Caffeic Acid is an endogenous phenolic phytochemical compound that inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), in a non-competitive manner, and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis involved in immunoregulation, inflammation and allergy. Caffeic acid has antioxidant, immunomodulatory, antiviral, anti-inflammatory, neuroprotective anti-proliferative and anticancer activity. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets and to stimulate prostaglandin synthesis at high doses. Caffeic Acid is an inhibitor of GST, ODC, Tyk, Fyn kinase and xanthine oxidase. Caffeic acid has been used as a standard of phenolic acid in the study to determine the total phenolic acid content in vegetables after subjecting to alkaline and acid hydrolysis.
Synonyms | 3,4-Dihydroxybenzeneacrylic acid, 3,4-Dihydroxycinnamic acid, 3-(3,4-Dihydroxyphenyl)-2-propenoic acid |
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Purity | ≥98% (HPLC) |
Appearance | White to light yellow powder |
CAS-Number | 331-39-5 |
Molecular Formula | C9H8O4 |
Molecular Weight | 180.16 |
Identity | 1H-NMR |
Solvents | ethanol (20 mg/ml) or DMSO (10 mg/ml). |
Melting Point | 225 °C (decomp.) |
Boiling Point | 416.8 °C (predicted) |
Density | 1.478 g/cm3 (predicted) |
Smiles | OC1=C(O)C=CC(/C=C/C(O)=O)=C1 |
InChi Key | QAIPRVGONGVQAS-DUXPYHPUSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Hazard statements | H351 |
Precautionary statements | P280 |
GHS Symbol | GHS08 |
Transportation | Not dangerous goods |
References | (1) Y. Koshihara, et al., Biochim. Biophys. Acta 792, 92 (1984), (2) N. Kohyama, et al., Biosci. Biotechnol. Biochem. 61, 347 (1997), (3) I. Shureiqi, et al., J. Natl. Cancer Inst. 92, 1136 (2000), (4) F.M. da Cunha, et al., Free Radic. Res. 38, 1241 (2004), (5) F. Bailly, et al., Curr. Med. Chem. 12, 1811 (2005), (6) N.J. Kang, et al., Carcinogenesis 30, 321 (2009), (7) K.M.M. Espindola, et al., Front. Oncol. 9, 541 (2009) (Review), (8) N. Rajendra Prasad, et al., Mol. Cell Biochem. 349, 11 (2011), (9) M. Touaibia, et al., Mini Rev. Med. Chem. 11, 695 (2011) (Review), (10) S. Lee, et al., PLoS One 9, e87708 (2014), (11) F.A. Khan, et al., J. Food Drug Anal. 24, 695 (2016) (Review), (12) S. Habtemariam, Mini Rev. Med. Chem. 17, 667 (2017) (Review) |
InChi | InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+ |
Quantity | 5 g, 25 g, Bulk |