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    Cantharidin

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      Cantharidin

      SKU
      C0643

      Category: Phytochemicals

      Synonyms
      3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione , 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran , Cantharidine , Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione , NSC61805 , BRN 0085302
      56-25-7
      CAS-Number
      C10H12O4
      Molecular Formula
      196.2
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Identity
      1H-NMR
      Appearance
      White to off-white powder

      Properties

      Solvents
      DMSO, ethanol
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      +4°C
      Short Term Storage
      +4°C
      Shipping
      AMBIENT
      Transportation
      Packing Group II
      RIDADR
      UN 2811 6.1
      Signal word
      Danger
      GHS Symbol
      GHS06
      Precautionary statements
      P305 + P351 + P338
      Hazard statements
      H300-H315-H319-H335
      Description
      Cantharidin is a natural toxin produced by blister beetles. It is a selective protein phosphatase 2A (PP2A) inhibitor and weakly inhibits protein phosphatases 1 (PP1). Displays > 500-fold selectivity over PP2B. Induces G2/M phase arrest and apoptosis, suppresses autophagy and inhibits cell proliferation. It is used topically against Molluscum contagiosum virus (MCV) infections and associated warts. Has shown potent anticancer activities on many types of human cancer cells.
      InChi
      InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-
      References
      (1) Y.M. Li & J.E. Casida, PNAS 89, 11867 (1992) , (2) Y.M. Li, et al., Biochem. Pharmacol. 46, 1435 (1993) , (3) R.E. Honkanen, et al., FEBS Lett. 330, 283 (1993) , (4) W. Li, et al., Cancer Sci. 101, 1226 (2010) , (5) L.P. Deng, et al., Curr. Med. Chem. 20, 159 (2013) (Review) , (6) A.P. Le, et al., Oncol. Rep. 35, 2970 (2016) , (7) X. Sun, et al., Mol. Cells 39, 869 (2016) , (8) H.C. Li, et al., Cell Physiol. Biochem. 43, 1829 (2017) , (9) G. Wang , et al., Curr. Med. Chem. (Epub ahead of print) (2017)
      InChi Key
      DHZBEENLJMYSHQ-XCVPVQRUSA-N
      Smiles
      C[C@]12[C@](C(OC2=O)=O)(C)[C@@H]3CC[C@H]1O3

      Cantharidin is a natural toxin produced by blister beetles. It is a selective protein phosphatase 2A (PP2A) inhibitor and weakly inhibits protein phosphatases 1 (PP1). Displays > 500-fold selectivity over PP2B. Induces G2/M phase arrest and apoptosis, suppresses autophagy and inhibits cell proliferation. It is used topically against Molluscum contagiosum virus (MCV) infections and associated warts. Has shown potent anticancer activities on many types of human cancer cells.

      SKU: C0643 Category: Phytochemicals
      • Additional information

      Additional information

      Synonyms

      3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione, 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran, Cantharidine, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione, NSC61805, BRN 0085302

      Purity

      ≥98% (HPLC)

      Appearance

      White to off-white powder

      CAS-Number

      56-25-7

      Molecular Formula

      C10H12O4

      Molecular Weight

      196.2

      Identity

      1H-NMR

      Solvents

      DMSO, ethanol

      Smiles

      C[C@]12[C@](C(OC2=O)=O)(C)[C@@H]3CC[C@H]1O3

      InChi Key

      DHZBEENLJMYSHQ-XCVPVQRUSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Hazard statements

      H300-H315-H319-H335

      Precautionary statements

      P305 + P351 + P338

      GHS Symbol

      GHS06

      Signal word

      Danger

      RIDADR

      UN 2811 6.1

      Transportation

      Packing Group II

      References

      (1) Y.M. Li & J.E. Casida, PNAS 89, 11867 (1992), (2) Y.M. Li, et al., Biochem. Pharmacol. 46, 1435 (1993), (3) R.E. Honkanen, et al., FEBS Lett. 330, 283 (1993), (4) W. Li, et al., Cancer Sci. 101, 1226 (2010), (5) L.P. Deng, et al., Curr. Med. Chem. 20, 159 (2013) (Review), (6) A.P. Le, et al., Oncol. Rep. 35, 2970 (2016), (7) X. Sun, et al., Mol. Cells 39, 869 (2016), (8) H.C. Li, et al., Cell Physiol. Biochem. 43, 1829 (2017), (9) G. Wang , et al., Curr. Med. Chem. (Epub ahead of print) (2017)

      InChi

      InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-

      Quantity

      100 mg, 500 mg, Bulk

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