Cantharidin

SKU: C0643

Category: Phytochemicals

Synonyms: 3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione , 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran , Cantharidine , Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione , NSC61805 , BRN 0085302; 56-25-7
CAS-Number: C₁₀H₁₂O₄
Molecular Formula: 196.2
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Solvents: DMSO, ethanol

Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.
Handling Advice: Protect from light and moisture.
Long Term Storage: +4°C
Short Term Storage: +4°C
Shipping: AMBIENT

Transportation: Packing Group II
RIDADR: UN 2811 6.1
Signal word: Danger
GHS Symbol: GHS06
Precautionary statements: P305 + P351 + P338
Hazard statements: H300-H315-H319-H335

Description: Cantharidin is a natural toxin produced by blister beetles. It is a selective protein phosphatase 2A (PP2A) inhibitor and weakly inhibits protein phosphatases 1 (PP1). Displays > 500-fold selectivity over PP2B. Induces G2/M phase arrest and apoptosis, suppresses autophagy and inhibits cell proliferation. It is used topically against Molluscum contagiosum virus (MCV) infections and associated warts. Has shown potent anticancer activities on many types of human cancer cells.
InChi: InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-
References: (1) Y.M. Li & J.E. Casida, PNAS 89, 11867 (1992) , (2) Y.M. Li, et al., Biochem. Pharmacol. 46, 1435 (1993) , (3) R.E. Honkanen, et al., FEBS Lett. 330, 283 (1993) , (4) W. Li, et al., Cancer Sci. 101, 1226 (2010) , (5) L.P. Deng, et al., Curr. Med. Chem. 20, 159 (2013) (Review) , (6) A.P. Le, et al., Oncol. Rep. 35, 2970 (2016) , (7) X. Sun, et al., Mol. Cells 39, 869 (2016) , (8) H.C. Li, et al., Cell Physiol. Biochem. 43, 1829 (2017) , (9) G. Wang , et al., Curr. Med. Chem. (Epub ahead of print) (2017)
InChi Key: DHZBEENLJMYSHQ-XCVPVQRUSA-N
Smiles: C[C@]12[C@](C(OC2=O)=O)(C)[C@@H]3CC[C@H]1O3

Cantharidin is a natural toxin produced by blister beetles. It is a selective protein phosphatase 2A (PP2A) inhibitor and weakly inhibits protein phosphatases 1 (PP1). Displays > 500-fold selectivity over PP2B. Induces G2/M phase arrest and apoptosis, suppresses autophagy and inhibits cell proliferation. It is used topically against Molluscum contagiosum virus (MCV) infections and associated warts. Has shown potent anticancer activities on many types of human cancer cells.

SKU: C0643 Category: Phytochemicals

Additional information

Additional information

Synonyms	3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione, 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran, Cantharidine, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione, NSC61805, BRN 0085302
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	56-25-7
Molecular Formula	C10H12O4
Molecular Weight	196.2
Identity	1H-NMR
Solvents	DMSO, ethanol
Smiles	C[C@]12[C@](C(OC2=O)=O)(C)[C@@H]3CC[C@H]1O3
InChi Key	DHZBEENLJMYSHQ-XCVPVQRUSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H300-H315-H319-H335
Precautionary statements	P305 + P351 + P338
GHS Symbol	GHS06
Signal word	Danger
RIDADR	UN 2811 6.1
Transportation	Packing Group II
References	(1) Y.M. Li & J.E. Casida, PNAS 89, 11867 (1992), (2) Y.M. Li, et al., Biochem. Pharmacol. 46, 1435 (1993), (3) R.E. Honkanen, et al., FEBS Lett. 330, 283 (1993), (4) W. Li, et al., Cancer Sci. 101, 1226 (2010), (5) L.P. Deng, et al., Curr. Med. Chem. 20, 159 (2013) (Review), (6) A.P. Le, et al., Oncol. Rep. 35, 2970 (2016), (7) X. Sun, et al., Mol. Cells 39, 869 (2016), (8) H.C. Li, et al., Cell Physiol. Biochem. 43, 1829 (2017), (9) G. Wang , et al., Curr. Med. Chem. (Epub ahead of print) (2017)
InChi	InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-
Quantity	100 mg, 500 mg, Bulk