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    Caroverin

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      Caroverin

      SKU
      C0260

      Category: API's & Intermediates

      Synonyms
      1-[2-(Diethylamino)ethyl]-3-(p-methoxybenzyl)-2-quinoxalone
      23465-76-1
      CAS-Number
      C22H27N3O2
      Molecular Formula
      365.47
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥99% (HPLC)
      Identity
      1H-NMR
      Appearance
      White or slightly yellow, fine powder

      Properties

      Melting Point
      66.0-69.0 °C
      Solvents
      DMSO (10 mg/ml), water (insoluble)
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Long Term Storage
      +4°C
      Short Term Storage
      RT
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Signal word
      Warning
      GHS Symbol
      GHS07
      Precautionary statements
      P264, P270, P301+P312, P330, P501
      Hazard statements
      H302
      Description
      Quinoxaline compound, originally developed as a spasmolytic drug. Acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist. Antioxidant agent through partial prevention of the formation and the highly active scavenging of hydroxyl radicals. Used to treat inner ear diseases such as tinnitus. Shown to inhibit tumor-promoting factors and potentially useful as a chemotherapeutic agent.
      InChi
      InChI=1S/C22H27N3O2/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17/h6-13H,4-5,14-16H2,1-3H3
      References
      Y. Ishida, et al., Br. J. Pharmacol. 71, 343 (1980) , B. Saletu, et al., Arzneimittelforsch. 45, 217 (1995) , D.M. Denk, et al., Acta Otolaryngol. 117, 825 (1997) , H. Nohl, et al., Biofactors 19, 79 (2003) , G. Haymerle, et al., Eur. Arch. Otorhinolaryngol. 272, 3451 (2015)
      InChi Key
      MSPRUJDUTKRMLM-UHFFFAOYSA-N
      Smiles
      O=C1N(CCN(CC)CC)C2=C(C=CC=C2)N=C1CC3=CC=C(OC)C=C3

      Quinoxaline compound, originally developed as a spasmolytic drug. Acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist. Antioxidant agent through partial prevention of the formation and the highly active scavenging of hydroxyl radicals. Used to treat inner ear diseases such as tinnitus. Shown to inhibit tumor-promoting factors and potentially useful as a chemotherapeutic agent.

      SKU: C0260 Category: API's & Intermediates
      • Additional information

      Additional information

      Synonyms

      1-[2-(Diethylamino)ethyl]-3-(p-methoxybenzyl)-2-quinoxalone

      Purity

      ≥99% (HPLC)

      Appearance

      White or slightly yellow, fine powder

      CAS-Number

      23465-76-1

      Molecular Formula

      C22H27N3O2

      Molecular Weight

      365.47

      Identity

      1H-NMR

      Solvents

      DMSO (10 mg/ml), water (insoluble)

      Melting Point

      66.0-69.0 °C

      Smiles

      O=C1N(CCN(CC)CC)C2=C(C=CC=C2)N=C1CC3=CC=C(OC)C=C3

      InChi Key

      MSPRUJDUTKRMLM-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Hazard statements

      H302

      Precautionary statements

      P264, P270, P301+P312, P330, P501

      GHS Symbol

      GHS07

      Signal word

      Warning

      Transportation

      Not dangerous goods

      References

      Y. Ishida, et al., Br. J. Pharmacol. 71, 343 (1980), B. Saletu, et al., Arzneimittelforsch. 45, 217 (1995), D.M. Denk, et al., Acta Otolaryngol. 117, 825 (1997), H. Nohl, et al., Biofactors 19, 79 (2003), G. Haymerle, et al., Eur. Arch. Otorhinolaryngol. 272, 3451 (2015)

      InChi

      InChI=1S/C22H27N3O2/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17/h6-13H,4-5,14-16H2,1-3H3

      Quantity

      10 mg, 50 mg, Bulk

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