Specifications
- Purity
- ≥98%
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO
- Melting Point
- 200-203 °C (lit.)
- Optical Activity
- +35° ~ +39°
Available from stock
Cefpodoxime
- SKU
- C0361
Category: API's & Intermediates
- Synonyms
- (6R,7R)-7-{2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetamido}-3-(methoxymethyl)-3-cephem-4-carboxylate , R 3763
- 80210-62-4
- CAS-Number
- C15H17N5O6S2
- Molecular Formula
- 427.46
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H317, H334
- Precautionary statements
- P261, P280, P342 + P311
- GHS Symbol
- GHS08
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- Cefpodoxime is a metabolite of cefpodoxime proxetil, an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria (MIC90 ranges from 0.015-8 µg/ml). It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime inhibits cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis in cell walls.
- Smiles
- O=C1[C@@H](NC(/C(C2=CSC(N)=N2)=N/OC)=O)[C@]3([H])N1C(C(O)=O)=C(COC)CS3
- InChi Key
- WYUSVOMTXWRGEK-HBWVYFAYSA-N
- References
- (1) K. Fujimoto, et al., J. Antibiot. 40, 370 (1987) , (2) Y. Utsui, et al., Antimicrob. Agents Chemother. 31, 1085 (1987) , (3) P. Angehrn, et al., Antimicrob. Agents Chemother. 36, 2825 (1992) , (4) J.E. Frampton, et al., Drugs 44, 889 (1992) (Review) , (5) E.C. Chocas, et al., Ann. Pharmacother. 27, 1369 (1993) (Review)
Cefpodoxime is a metabolite of cefpodoxime proxetil, an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria (MIC90 ranges from 0.015-8 µg/ml). It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime inhibits cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis in cell walls.
Additional information
| Synonyms | (6R,7R)-7-{2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetamido}-3-(methoxymethyl)-3-cephem-4-carboxylate, R 3763 |
|---|---|
| Purity | ≥98% |
| Appearance | White to off-white powder |
| CAS-Number | 80210-62-4 |
| Molecular Formula | C15H17N5O6S2 |
| Molecular Weight | 427.46 |
| Identity | 1H-NMR |
| Solvents | DMSO |
| Melting Point | 200-203 °C (lit.) |
| Optical Activity | +35° ~ +39° |
| Smiles | O=C1[C@@H](NC(/C(C2=CSC(N)=N2)=N/OC)=O)[C@]3([H])N1C(C(O)=O)=C(COC)CS3 |
| InChi Key | WYUSVOMTXWRGEK-HBWVYFAYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H317, H334 |
| Precautionary statements | P261, P280, P342 + P311 |
| GHS Symbol | GHS08 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) K. Fujimoto, et al., J. Antibiot. 40, 370 (1987), (2) Y. Utsui, et al., Antimicrob. Agents Chemother. 31, 1085 (1987), (3) P. Angehrn, et al., Antimicrob. Agents Chemother. 36, 2825 (1992), (4) J.E. Frampton, et al., Drugs 44, 889 (1992) (Review), (5) E.C. Chocas, et al., Ann. Pharmacother. 27, 1369 (1993) (Review) |
| Quantity | 25 mg, 100 mg, Bulk |
