Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- ethanol, DMSO, DMF, PBS (pH 72) (all (25 mg/ml)
- Melting Point
- 210 °C (dec.)(lit.)
- Density
- 1.28 g/cm3 (lit.)
Category: Phytochemicals
Chlorogenic acid is a phenolic natural product isolated from the leaves and fruits of dicotyledonous plants, including the coffee bean. Structurally, it is the ester of caffeic acid with the 3-hydroxyl group of quinic acid. Chlorogenic acid is an intermediate in lignin biosynthesisis an therefore an important factor in plant metabolism. This compound has been shown to have a broad range of biological properties, including hepatoprotective, antioxidant, neuroprotective, anti-diabetic, antimicrobial, anticarcinogenic, anti-inflammatory and anti-obesity activities. Recent studies showed the involvement in regulating glucose and lipid metabolism, improving insulin sensitivity and promotion of weight loss. In addition it has to have modulatory activities on the microbiota.
Synonyms | CGA, 3-CQA, 1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate), 3-(3,4-Dihydroxycinnamoyl)quinic acid, 3-O-Caffeoylquinic Acid |
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Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 327-97-9 |
Molecular Formula | C16H18O9 |
Molecular Weight | 354.31 |
Identity | 1H-NMR |
Solvents | ethanol, DMSO, DMF, PBS (pH 72) (all (25 mg/ml) |
Melting Point | 210 °C (dec.)(lit.) |
Density | 1.28 g/cm3 (lit.) |
Smiles | O[C@]1(C(O)=O)CC(OC(/C=C/C2=CC=C(O)C(O)=C2)=O)[C@H](O)[C@@H](O)C1 |
InChi Key | CWVRJTMFETXNAD-BBVNJSSOSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) M.T. Huang, et al., Cancer Res. 48, 5941 (1988), (2) M.T. Huang, et al., Cancer Res. 51, 813 (1991), (3) R. Feng, et al., J. Biol. Chem. 280, 27888 (2005), (4) M.D. dos Santos, et al., Biol. Pharm. Bull. 29, 2236 (2006), (5) W.J. Lee & B.T. Zhu, Carcinogenesis 27, 269 (2006), (6) W.C. Chang, et al., Eur. J. Nutr. 49, 267 (2010), (7) S. Meng, et al., Evid. Based Complement Alternat. Med. 2013, 801457 (2013) (Review), (8) E. Heitman & D.K. Ingram, Nutr. Neurosci. 20, 32 (2017) (Review), (9) J. Santana-Galvez, et al., Molecules 22, E358 (2017) (Review), (10) M. Naveed, et al., Biomed. Pharmacother. 97, 67 (2018) (Review), (11) X. Wang, et al., J. Pharm. Pharmacol. 71, 1100 (2019), (12) J.K. Kim & S.U. Park, EXCLI J. 18, 310 (2019) (Review) |
Quantity | 1 g, 5 g, Bulk |