Available from stock

Clindamycin hydrochloride

SKU: C0324

Category: Antibiotics

Synonyms: (7S)-7-Chloro-7-deoxylincomycin hydrochloride, NSC-756696, U21251F, Cleocin; 21462-39-5
CAS-Number: C₁₈H₃₃ClN₂O₅S . HCl
Molecular Formula: 461.44
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥97% (TLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: Soluble in water (50mg/ml) or DMSO (50mg/ml).

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H317 - H319 - H362
Precautionary statements: P260 - P263 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: Clindamycin hydrochloride is a semi-synthetic, lincosamide antibiotic that is prepared from lincomycin. It inhibits bacterial protein synthesis by hydrogen bond interactions with the 23S rRNA component of the 50S ribosomal subunit thus inducing dissociation of the peptidyl-t-RNA complex. It has antibacterial activity against Gram-positive cocci and antiprotozoal activity against Taxoplasma. Clindamycin is used to study bacterial infections, such as group B streptococcal disease, bacterial resistance and plasma protein binding and used to study bacterial protein synthesis.
Smiles: O[C@H]1[C@@H](SC)O[C@]([H])([C@@H]([C@H](C)Cl)NC([C@]2([H])C[C@@H](CCC)CN2C)=O)[C@H](O)[C@@H]1O.Cl
InChi Key: AUODDLQVRAJAJM-XJQDNNTCSA-N
References: (1) M. Smieja; Can. J. Inf. Dis. Med. Microbiol. 9, 22 (1998) , (2) W.S. Champney; Curr. Drug Targets Infect. Disord. 1, 19 (2001) , (3) B. Lell & P.G. Kremsner; Antimicr. Agents Chemother. 46, 2315 (2002) , (4) J. Spizek & T. Rezanka; Appl. Microbiol. Biotech. 64, 455 (2004) , (5) J. Spizek, et al.; Adv. Appl. Microbiol. 56, 121 (2004) , (6) E.S.R. Darley & A.P. MacGowan; J. Antimicrob. Chemother. 53, 928 (2004) , (7) D.N. Wilson; Nat. Rev. Microbiol. 12, 35 (2014)
InChi: InChI=1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+;/m0./s1

Clindamycin hydrochloride is a semi-synthetic, lincosamide antibiotic that is prepared from lincomycin. It inhibits bacterial protein synthesis by hydrogen bond interactions with the 23S rRNA component of the 50S ribosomal subunit thus inducing dissociation of the peptidyl-t-RNA complex. It has antibacterial activity against Gram-positive cocci and antiprotozoal activity against Taxoplasma. Clindamycin is used to study bacterial infections, such as group B streptococcal disease, bacterial resistance and plasma protein binding and used to study bacterial protein synthesis.

SKU: C0324 Category: Antibiotics

Additional information

Additional information

Synonyms	(7S)-7-Chloro-7-deoxylincomycin hydrochloride, NSC-756696, U21251F, Cleocin
Purity	≥97% (TLC)
Appearance	White to off-white powder
CAS-Number	21462-39-5
Molecular Formula	C18H33ClN2O5S . HCl
Molecular Weight	461.44
Identity	1H-NMR
Solvents	Soluble in water (50mg/ml) or DMSO (50mg/ml).
Smiles	O[C@H]1[C@@H](SC)O[C@]([H])([C@@H]([C@H](C)Cl)NC([C@]2([H])C[C@@H](CCC)CN2C)=O)[C@H](O)[C@@H]1O.Cl
InChi Key	AUODDLQVRAJAJM-XJQDNNTCSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H317 – H319 – H362
Precautionary statements	P260 – P263 – P280 – P302 + P352 – P305 + P351 + P338 – P308 + P313
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) M. Smieja; Can. J. Inf. Dis. Med. Microbiol. 9, 22 (1998), (2) W.S. Champney; Curr. Drug Targets Infect. Disord. 1, 19 (2001), (3) B. Lell & P.G. Kremsner; Antimicr. Agents Chemother. 46, 2315 (2002), (4) J. Spizek & T. Rezanka; Appl. Microbiol. Biotech. 64, 455 (2004), (5) J. Spizek, et al.; Adv. Appl. Microbiol. 56, 121 (2004), (6) E.S.R. Darley & A.P. MacGowan; J. Antimicrob. Chemother. 53, 928 (2004), (7) D.N. Wilson; Nat. Rev. Microbiol. 12, 35 (2014)
InChi	InChI=1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+;/m0./s1
Quantity	10 g, 25 g, Bulk