• Home
Results for {phrase} ({results_count} of {results_count_total})
Displaying {results_count} results of {results_count_total}

More results...

Filter by Product categories
Bioactive Molecules
Amino Acids, Peptides, Proteins
Carbohydrates
Lipids, Fatty Acids
Metabolites
Phytochemicals
Vitamins
Bioactive Small Molecules
Biopolymers
Detection in Bioanalysis
Fluorescent Detection
Organic Pollutants & Pesticides
Fungicides
Herbicides
Insecticides
Other Pollutants
Pharmaceutically Actives
Antibiotics
API's & Intermediates
Steroids
Reagents and Building Blocks
Reagents for Life Sciences
Buffers
Building Blocks, Intermediates, Reagents
Fluorescent Detection
Linker
Non Fluorescent Detection & Chromogene Detection
Quorum Sensing
Uncategorized
    Industriestrasse 15, CH-9015 St. Gallen, Tel: +41 71 244 48 25
    • 0Shopping Cart
    Chemodex
    • Home
    • Products
    • Catalogs
    • About Chemodex
    • Contact & Distributors
    • Menu Menu
    Clomiphene citrate

    Available from stock

      Inquiry

      Please fill out the form for your inquiry:



      * required field

      Clomiphene citrate

      SKU
      C0696

      Category: API's & Intermediates

      Synonyms
      Clomifene , Omifin , NSC 35770 , 2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine , Clomiphene citrate salt
      50-41-9
      CAS-Number
      C26H28ClNO · C6H8O7
      Molecular Formula
      598.08
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Appearance
      Solid
      Identity
      1H-NMR

      Properties

      Solvents
      DMSO, DMF, water (slightly), methanol (slightly), chloroform (slightly)
      Shipping
      AMBIENT
      Short Term Storage
      +4°C
      Long Term Storage
      +4°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Hazard statements
      H361
      Precautionary statements
      P281
      GHS Symbol
      GHS08
      Signal word
      Warning
      Transportation
      Not dangerous goods
      Description
      Clomiphene is a nonsteroidal triphenylethylene derivative. It acts as a selective estrogen receptor modulator (SERM), that impairs the activation of estrogen receptors (ERs) by 17β-estradiol, similar to tamoxifen and raloxifene. It potently binds both ERα and ERβ (Ki = 0.9 and 1.2nM, respectively). Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation. Triphenylethylene antiestrogens may also be used as antileukemic drugs which kill cells by apoptosis mediated by oxidative stress and activation of PKC.
      Smiles
      Cl/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)C3=CC=C(OCCN(CC)CC)C=C3.OC(CC(O)=O)(C(O)=O)CC(O)=O
      InChi Key
      PYTMYKVIJXPNBD-BTKVJIOYSA-N
      References
      (1) J.H. Clark & B.M. Markaverich, Pharmacol. Ther. 15, 467 (1981) , (2) E.Y. Adashi, Fertil. Steril. 42, 331 (1984) , (3) E. Kousta, et al., Hum. Reprod. Update 3, 359 (1997) , (4) G.G.J.M. Kuiper, et al., Endocrinology 138, 863 (1997) , (5) T. Hayon, et al., Anticancer Res. 19, 2089 (1999) , (6) S.G. Haskell, South Med. J. 96, 469 (2003) , (7) R. Homburg, Hum. Reprod. 20, 2043 (2005) , (8) M. Amita, et al., Endocrinology 151, 394 (2010)

      Clomiphene is a nonsteroidal triphenylethylene derivative. It acts as a selective estrogen receptor modulator (SERM), that impairs the activation of estrogen receptors (ERs) by 17β-estradiol, similar to tamoxifen and raloxifene. It potently binds both ERα and ERβ (Ki = 0.9 and 1.2nM, respectively). Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation. Triphenylethylene antiestrogens may also be used as antileukemic drugs which kill cells by apoptosis mediated by oxidative stress and activation of PKC.

      SKU: C0696 Category: API's & Intermediates
      • Additional information

      Additional information

      Synonyms

      Clomifene, Omifin, NSC 35770, 2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine, Clomiphene citrate salt

      Purity

      ≥98% (HPLC)

      Appearance

      Solid

      CAS-Number

      50-41-9

      Molecular Formula

      C26H28ClNO · C6H8O7

      Molecular Weight

      598.08

      Identity

      1H-NMR

      Solvents

      DMSO, DMF, water (slightly), methanol (slightly), chloroform (slightly)

      Smiles

      Cl/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)C3=CC=C(OCCN(CC)CC)C=C3.OC(CC(O)=O)(C(O)=O)CC(O)=O

      InChi Key

      PYTMYKVIJXPNBD-BTKVJIOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Hazard statements

      H361

      Precautionary statements

      P281

      GHS Symbol

      GHS08

      Signal word

      Warning

      Transportation

      Not dangerous goods

      References

      (1) J.H. Clark & B.M. Markaverich, Pharmacol. Ther. 15, 467 (1981), (2) E.Y. Adashi, Fertil. Steril. 42, 331 (1984), (3) E. Kousta, et al., Hum. Reprod. Update 3, 359 (1997), (4) G.G.J.M. Kuiper, et al., Endocrinology 138, 863 (1997), (5) T. Hayon, et al., Anticancer Res. 19, 2089 (1999), (6) S.G. Haskell, South Med. J. 96, 469 (2003), (7) R. Homburg, Hum. Reprod. 20, 2043 (2005), (8) M. Amita, et al., Endocrinology 151, 394 (2010)

      Quantity

      1 g, 5 g, Bulk

      Related products

      • Diclofenac acid

        Diclofenac acid

        Purity: ≥98% (HPLC)CAS-Number: 15307-86-5SKU: D0147

        Read more Show Details
      • Carbamoylcholine chloride

        Carbamoylcholine chloride

        Purity: ≥99%CAS-Number: 51-83-2SKU: C0306

        Read more Show Details
      • Gemcitabine hydrochloride

        Gemcitabine hydrochloride

        Purity: ≥98% (HPLC)CAS-Number: 122111-03-9SKU: G0063

        Read more Show Details
      • Enalaprilat

        Enalaprilat

        Purity: ≥99% (HPLC)CAS-Number: 76420-72-9SKU: E0090

        Read more Show Details
      © Copyright - Chemodex AG - Customized Molecules developed in Switzerland
      • Home
      • All products
      • Order and delivery information
      • Disclaimer
      • Privacy policy
      • About this site
      Sulfo-NHS-LC-BiotinSulfo-NHS-LC-BiotinKetorolac tris saltKetorolac tris salt Scroll to top