Specifications
- Purity
- ≥98% (T)
- Identity
- 1H-NMR
- Appearance
- Yellow to orange powder
Properties
- Melting Point
- 48.0 - 52.0 °C
- Solvents
- ethanol (1mg/ml), DMF (10mg/ml), chloroform (20mg/ml), water (insoluble)
Available from stock
Coenzyme Q10
- SKU
- C0661
Category: Vitamins
- Synonyms
- CoQ10 , NSC 140865 , Ubidecarenone , Ubiquinone-10 , Ubiquinone Q10 , Q-10 , Vitamin Q
- 303-98-0
- CAS-Number
- C59H90O4
- Molecular Formula
- 863.34
- Molecular Weight
- Shipping
- AMBIENT
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Handling Advice
- Protect from light and moisture.
- Long Term Storage
- -20°C
- Short Term Storage
- +4°C
- Transportation
- Not dangerous goods
- Description
- Coenzyme Q10 (CoQ10) is a component of the electron transport chain of the mitochondria and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, CoQ10 acts as an antioxidant, preventing the formation of reactive oxygen species and displaying neuroprotective activity. CoQ10 deficiencies have been associated with heart failure, hypertension, parkinsonism, mitochondrial encephalomyopathies and other chronic diseases. Shown to modulate the nitric oxide pathway, inhibit LDL oxidation and suppress the down regulation of NOSIII (endothelial nitric oxide synthase, eNOS) and up-regulation of NOSII (inducible nitric oxide synthase, iNOS).
- References
- (1) F.L. Crane, J. Am. Coll. Nutr. 20, 591 (2001) , (2) C.W. Shults, Curr. Med. Chem. 10, 1917 (2003) , (3) A.J. Young, et al, CNS Spectr. 12, 62 (2007) , (4) R. Saini, J. Pharm. Bioallied Sci. 3, 466 (2011) , (5) C.M. Quinzii & M. Hirano, BioFactors 37, 361 (2011) , (6) I. Bogeski, et al., JACS 133, 9293 (2011) , (7) K.L. Tsai, et al., J. Nutr. Biochem. 23, 458 (2012)
- InChi Key
- ACTIUHUUMQJHFO-UPTCCGCDSA-N
- Smiles
- O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(CC/C=C(C)/CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)C)C)=C(C)C1=O
Coenzyme Q10 (CoQ10) is a component of the electron transport chain of the mitochondria and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, CoQ10 acts as an antioxidant, preventing the formation of reactive oxygen species and displaying neuroprotective activity. CoQ10 deficiencies have been associated with heart failure, hypertension, parkinsonism, mitochondrial encephalomyopathies and other chronic diseases. Shown to modulate the nitric oxide pathway, inhibit LDL oxidation and suppress the down regulation of NOSIII (endothelial nitric oxide synthase, eNOS) and up-regulation of NOSII (inducible nitric oxide synthase, iNOS).
Additional information
| Synonyms | CoQ10, NSC 140865, Ubidecarenone, Ubiquinone-10, Ubiquinone Q10, Q-10, Vitamin Q |
|---|---|
| Purity | ≥98% (T) |
| Appearance | Yellow to orange powder |
| CAS-Number | 303-98-0 |
| Molecular Formula | C59H90O4 |
| Molecular Weight | 863.34 |
| Identity | 1H-NMR |
| Solvents | ethanol (1mg/ml), DMF (10mg/ml), chloroform (20mg/ml), water (insoluble) |
| Melting Point | 48.0 – 52.0 °C |
| Smiles | O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(CC/C=C(C)/CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)C)C)=C(C)C1=O |
| InChi Key | ACTIUHUUMQJHFO-UPTCCGCDSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) F.L. Crane, J. Am. Coll. Nutr. 20, 591 (2001), (2) C.W. Shults, Curr. Med. Chem. 10, 1917 (2003), (3) A.J. Young, et al, CNS Spectr. 12, 62 (2007), (4) R. Saini, J. Pharm. Bioallied Sci. 3, 466 (2011), (5) C.M. Quinzii & M. Hirano, BioFactors 37, 361 (2011), (6) I. Bogeski, et al., JACS 133, 9293 (2011), (7) K.L. Tsai, et al., J. Nutr. Biochem. 23, 458 (2012) |
| Quantity | 500 mg, 1 g, Bulk |
