Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- water, ethanol, DMSO
Available from stock
Cordycepin
- SKU
- C0339
Category: Antibiotics
- Synonyms
- 3'-Deoxyadenosine , NSC 63984 , NSC 401022 , 9-Cordyceposidoadenine , BRN 0035194
- 73-03-0
- CAS-Number
- C10H13N5O3
- Molecular Formula
- 251.24
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- RIDADR
- UN2811 6.1
- Transportation
- Packing Group III
- Description
- Cordycepin is a nucleoside (adenosine analog) antibiotic that acts as a polyadenylation inhibitor when converted to 3’-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA and RNA synthesis. Cordycepin has a broad spectrum of biological activities, including anticancer, anti-proliferative, pro-apoptotic, anti-inflammatory and antifungal effects. It was shown to modulate autophagy and NLRP3 inflammasome. Cordycepin has been shown to reduce poly(A) tail length in mRNA, to activate AMPK kinase, leading to a reduction in mTOR signalling, downregulate ERK/Akt/PI3K/GSK-3β/β-catenin signaling pathways. Also useful for the study of messenger RNA transcription.
- Smiles
- OC[C@@H]1C[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O1
- InChi Key
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N
- References
- (1) G.G. Lovinger, et al., Virology 55, 524 (1973) , (2) R.I. Gumport, et al., Biochemistry 15, 2804 (1976) , (3) A.M. Sugar & R.P. McCaffrey, Antimicrob. Agents Chemother. 42, 1424 (1998) , (4) E.N. Kodama, et al., Biochem. Pharmacol. 59, 273 (2000) , (5) L.S. Chen, et al., Br. J. Haematol. 140, 682 (2008) , (6) Y.Y. Wong, et al., J. Biol. Chem. 285, 2610 (2010) , (7) H.J. Lee, et al., Invest. New Drugs 30, 1917 (2012) , (8) B.S. Ko, et al., PLoS One 8, e76320 (2013) , (9) H.S. Tuli, et al., Life Sci. 93, 863 (2013) (Review) , (10) C. Wu, et al., J. Cell Mol. Med. 18, 293 (2014) , (11) K. Nakamura, et al., J. Pharmacol. Sci. 127, 53 (2015) (Review) , (12) Y. Li, et al., Oncol. Lett. 9, 2541 (2015) , (13) J. Yang, et al., Biomed. Pharmacother. 95, 1777 (2017) , (14) Y. Wang, et al., Exp. Ther. Med. 14, 3067 (2017)
- InChi
- InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1
Cordycepin is a nucleoside (adenosine analog) antibiotic that acts as a polyadenylation inhibitor when converted to 3’-deoxyadenosine triphosphate (3′-dATP), which inhibits ATP-dependent DNA and RNA synthesis. Cordycepin has a broad spectrum of biological activities, including anticancer, anti-proliferative, pro-apoptotic, anti-inflammatory and antifungal effects. It was shown to modulate autophagy and NLRP3 inflammasome. Cordycepin has been shown to reduce poly(A) tail length in mRNA, to activate AMPK kinase, leading to a reduction in mTOR signalling, downregulate ERK/Akt/PI3K/GSK-3β/β-catenin signaling pathways. Also useful for the study of messenger RNA transcription.
Additional information
| Synonyms | 3'-Deoxyadenosine, NSC 63984, NSC 401022, 9-Cordyceposidoadenine, BRN 0035194 |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 73-03-0 |
| Molecular Formula | C10H13N5O3 |
| Molecular Weight | 251.24 |
| Identity | 1H-NMR |
| Solvents | water, ethanol, DMSO |
| Smiles | OC[C@@H]1C[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O1 |
| InChi Key | OFEZSBMBBKLLBJ-BAJZRUMYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| RIDADR | UN2811 6.1 |
| Transportation | Packing Group III |
| References | (1) G.G. Lovinger, et al., Virology 55, 524 (1973), (2) R.I. Gumport, et al., Biochemistry 15, 2804 (1976), (3) A.M. Sugar & R.P. McCaffrey, Antimicrob. Agents Chemother. 42, 1424 (1998), (4) E.N. Kodama, et al., Biochem. Pharmacol. 59, 273 (2000), (5) L.S. Chen, et al., Br. J. Haematol. 140, 682 (2008), (6) Y.Y. Wong, et al., J. Biol. Chem. 285, 2610 (2010), (7) H.J. Lee, et al., Invest. New Drugs 30, 1917 (2012), (8) B.S. Ko, et al., PLoS One 8, e76320 (2013), (9) H.S. Tuli, et al., Life Sci. 93, 863 (2013) (Review), (10) C. Wu, et al., J. Cell Mol. Med. 18, 293 (2014), (11) K. Nakamura, et al., J. Pharmacol. Sci. 127, 53 (2015) (Review), (12) Y. Li, et al., Oncol. Lett. 9, 2541 (2015), (13) J. Yang, et al., Biomed. Pharmacother. 95, 1777 (2017), (14) Y. Wang, et al., Exp. Ther. Med. 14, 3067 (2017) |
| InChi | InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1 |
| Quantity | 10 mg, 25 mg, 100 mg, Bulk |
