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      CPM

      SKU
      D0042

      Category: Fluorescent Detection

      Synonyms
      7-Diethylamino-3-(4-maleimidylphenyl)-4-methylcoumarin
      76877-33-3
      CAS-Number
      C24H22N2O4
      Molecular Formula
      402.44
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥95% (HPLC)
      Identity
      1H-NMR
      Appearance
      Yellow solid

      Properties

      Fluorescence
      λex 391 nm, λem 472 nm in methanol/2-mercaptoethanol
      Solvents
      DMSO, DMF, acetonitrile, chloroform

      Downloads

      Safety Data Sheet
      CDX D0042 MSDS.pdf
      Short Term Storage
      +4°C
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      -20°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      Widely used blue fluorescent thiol-reactive dye (Ex/Em: 384/470nm). This maleimide derivative of coumarin is essentially non-fluorescent until it reacts with thiols, making it possible to quantify thiols without a separation step. Good energy acceptor from tryptophan and a good energy donor to fluorescein. Used to monitor release of thiols and to distinguish proliferating cancer cells by nucleolar protein staining.
      InChi
      InChI=1S/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3
      References
      (1) C.C. Chung: Assay and Drug Devel. Techn. 6(3), 361 (2008) , (2) O. Khersonsky et al.: ChemBioChem 7(1), 49 (2006) , (3) J.E.T. Corrie et al.: J. Chem. Soc. Trans. Perkin Trans. 1, 2975 (1994)
      InChi Key
      YGIABALXNBVHBX-UHFFFAOYSA-N
      Smiles
      CCN(CC)C1=CC2=C(C=C1)C(C)=C(C(=O)O2)C1=CC=C(C=C1)N1C(=O)C=CC1=O

      Widely used blue fluorescent thiol-reactive dye (Ex/Em: 384/470nm). This maleimide derivative of coumarin is essentially non-fluorescent until it reacts with thiols, making it possible to quantify thiols without a separation step. Good energy acceptor from tryptophan and a good energy donor to fluorescein. Used to monitor release of thiols and to distinguish proliferating cancer cells by nucleolar protein staining.

      SKU: D0042 Category: Fluorescent Detection
      • Additional information

      Additional information

      Synonyms

      7-Diethylamino-3-(4-maleimidylphenyl)-4-methylcoumarin

      Purity

      ≥95% (HPLC)

      Appearance

      Yellow solid

      CAS-Number

      76877-33-3

      Molecular Formula

      C24H22N2O4

      Molecular Weight

      402.44

      Identity

      1H-NMR

      Solvents

      DMSO, DMF, acetonitrile, chloroform

      Fluorescence

      λex 391 nm, λem 472 nm in methanol/2-mercaptoethanol

      Smiles

      CCN(CC)C1=CC2=C(C=C1)C(C)=C(C(=O)O2)C1=CC=C(C=C1)N1C(=O)C=CC1=O

      InChi Key

      YGIABALXNBVHBX-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) C.C. Chung: Assay and Drug Devel. Techn. 6(3), 361 (2008), (2) O. Khersonsky et al.: ChemBioChem 7(1), 49 (2006), (3) J.E.T. Corrie et al.: J. Chem. Soc. Trans. Perkin Trans. 1, 2975 (1994)

      InChi

      InChI=1S/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3

      Quantity

      50 mg, 250 mg, Bulk

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