Specifications
- Purity
- ≥95%
- Appearance
- Yellow to orange solid
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (25 mg/ml) or ethanol (10 mg/ml).
- Melting Point
- 183 °C
- Boiling Point
- 591.4 °C (predicted)
- Density
- 1.279 g/cm3 (predicted)
Category: Phytochemicals
Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of anti-apoptotic gene products), proliferation (HER-2, EGFR and AP-1), survival (PI3K/AKT pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-4), tumorigenesis and development (Shh, Gli), metabolism (PPARγ, Nrf2), epigenetics (HDACs, HATs, DNA methyltransferase I and microRNAs) and inflammation (NLRP3, TLR4, NF-κB, TNF, IL-6, IL-1, COX-2 and 5-LOX).
Synonyms | (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Diferuloylmethane, Natural Yellow 3 |
---|---|
Purity | ≥95% |
Appearance | Yellow to orange solid |
CAS-Number | 458-37-7 |
Molecular Formula | C21H20O6 |
Molecular Weight | 368.38 |
Identity | 1H-NMR |
Solvents | DMSO (25 mg/ml) or ethanol (10 mg/ml). |
Melting Point | 183 °C |
Boiling Point | 591.4 °C (predicted) |
Density | 1.279 g/cm3 (predicted) |
Smiles | OC1=CC=C(/C=C/C(CC(/C=C/C2=CC(OC)=C(O)C=C2)=O)=O)C=C1OC |
InChi Key | VFLDPWHFBUODDF-FCXRPNKRSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) R.K. Maheshwari, et al., Life Sci. 78, 2081 (2006) (Review), (2) V.P. Menon & A.R. Sudheer, Adv. Exp. Med. Biol. 595, 105 (2007) (Review), (3) G. Kuttan, et al., Adv. Exp. Med. Biol. 595, 173 (2007) (Review), (4) B.B. Aggarwal & K.B. Harikumar, Int. J. Biochem. Cell Biol. 41, 40 (2009) (Review), (5) S. Fu & R. Kurzrock, Cancer 116, 4670 (2010) (Review), (6) L. Alappat & A.B. Awad, Nutr. Rev. 68, 729 (2010) (Review), (7) R.B. Mythri & M.M. Bharath, Curr. Pharm. Des. 18, 91 (2012) (Review), (8) A.A. Momtazi, et al., Rev. Physiol. Biochem. Pharmacol. 171, 1 (2016) (Review), (9) S.S. Soflaei, et al., Curr. Pharm. Des. 24, 123 (2018) (Review), (10) M. Boozari, et al., J. Cell Physiol. 234, 12471 (2019) (Review), (11) K.R. Kahkhaie, et al., Inflammopharmacol. 27, 885 (2019) (Review), (12) D.J.Den Hartogh, et al., Nutrients 12, 118 (2020) (Review), (13) D.J.Den Hartogh, et al., Nutrients 12, 58 (2020) (Review), (14) M.A. Panaro, et al., Int. J. Mol. Sci. 21, 2299 (2020) (Review), (15) M.R. Jennings & R.J. Parks, Viruses 12, 1242 (2020) (Review), (16) A.Saeedi-Boroujeni, et al., Basic. Clin. Pharmacol. Toxicol. 128, 37 (2021) (Review) |
InChi | InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+ |
Quantity | 10 g, 50 g, Bulk |