• Home
Search

Results for {phrase} ({results_count} of {results_count_total})

Displaying {results_count} results of {results_count_total}

More results...

Generic filters
Filter by Product categories
Bioactive Molecules
Amino Acids, Peptides, Proteins
Carbohydrates
Lipids, Fatty Acids
Metabolites
Phytochemicals
Vitamins
Bioactive Small Molecules
Biopolymers
Detection in Bioanalysis
Fluorescent Detection
Organic Pollutants & Pesticides
Fungicides
Herbicides
Insecticides
Other Pollutants
Pharmaceutically Actives
Antibiotics
API's & Intermediates
Steroids
Reagents and Building Blocks
Reagents for Life Sciences
Buffers
Building Blocks, Intermediates, Reagents
Fluorescent Detection
Linker
Non Fluorescent Detection & Chromogene Detection
Quorum Sensing
Uncategorized
    Industriestrasse 15, CH-9015 St. Gallen, Tel: +41 71 244 48 25
    • 0Shopping Cart
    Chemodex
    • Home
    • Products
    • Catalogs
    • About Chemodex
    • Contact & Distributors
    • Menu Menu
    D-Luciferin potassium salt

    Available from stock

      Inquiry

      Please fill out the form for your inquiry:



      * required field

      D-Luciferin potassium salt

      SKU
      L0009
      Synonyms
      (S)-2-(6-Hydroxy-2-benzothiazolyl)-2-thiazoline-4-carboxylic acid potassium salt , 4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid potassium salt , Firefly luciferin potassium salt
      115144-35-9
      CAS-Number
      C11H7KN2O3S2
      Molecular Formula
      318.41
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥95% (HPLC)
      Identity
      1H-NMR
      Appearance
      Light yellow solid

      Properties

      Solvents
      DMSO (10 mg/ml), water (10 mg/ml)
      Short Term Storage
      +4°C
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Handling Advice
      Very light-sensitive. Protect from light and moisture.
      Long Term Storage
      -20°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      D-Luciferin is the most popular and versatile bioluminescent substrate. Firefly luciferase produces light by the ATP-dependent oxidation (Mg2+ as cofactor) of luciferin. It emits a characteristic yellow-green emission in the presence of oxygen, which shifts to red light in vivo. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase activity when luciferin and ATP are present in excess. Firefly luciferase has long been conjugated to antibodies and used as a label in immunoassays using luciferin as the substrate for detection. One particular advantage to the enzyme is that there is low endogenous luciferase activity in mammalian tissues besides its high sensitivity. Through the utilization of ATP, the reaction can be further used to indicate the presence of energy or life in order to function as a life-death stain. Luciferin is a common reagent used throughout the biotechnology field and specifically for in vivo imaging. Luciferase labeled tumor cells, stem cells or infectious diseases are often inoculated into research animals such as rats or mice for investigation. The injection of luciferin allows for the real-time, non-invasive monitoring of disease progression and/or drug efficacy in these model systems through Bioluminescence Imaging (BLI). Luciferin is also commonly used for in vitro research, including luciferase and ATP assays, gene reporter assays, high throughput sequencing and various contamination assays (e.g. determine cell viability and bacteria counting).
      InChi
      InChI=1S/C11H8N2O3S2.K/c14-5-1-2-6-8(3-5)18-10(12-6)9-13-7(4-17-9)11(15)16 , /h1-3,7,14H,4H2,(H,15,16) , /q , +1/p-1/t7- , /m1./s1
      References
      (1) V.T. Nguyen, et al., Anal. Biochem. 171, 404 (1988) , (2) S.P. Crouch, et al., J. Immunol. Methods 160, 81 (1993) , (3) N. Lembert, Biochem. J. 317, 273 (1996) , (4) S.R. Ford, et al., Methods Mol. Biol. 102, 3 (1998) , (5) J.D. Day, et al., Luminescence 19, 8 (2004) (Review) , (6) V.R. Viviani & Y. Ohmiya, Luminescence 21, 262 (2006) , (7) M.L. Schipper, et al., Mol. Imaging Biol. 8, 218 (2006) , (8) S. Palomba, et al., Langmuir 22, 5451 (2006) , (9) S.T. Adams & S.C. Miller, Curr. Opin. Chem. Biol. 21, 112 (2014) (Review) , (10) T. Ishimoto, et al., J. Biol. Pharm. Bull. 2015, 1969 (2015) , (11) M. Kiyama, et al., Curr. Top. Med. Chem. 16, 2648 (2016) (Review)
      InChi Key
      UMBKGTQQGYPQBE-OGFXRTJISA-M
      Smiles
      OC1=CC=C2C(SC(C3=N[C@@H](C([O-])=O)CS3)=N2)=C1.[K+]

      D-Luciferin is the most popular and versatile bioluminescent substrate. Firefly luciferase produces light by the ATP-dependent oxidation (Mg2+ as cofactor) of luciferin. It emits a characteristic yellow-green emission in the presence of oxygen, which shifts to red light in vivo. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase activity when luciferin and ATP are present in excess. Firefly luciferase has long been conjugated to antibodies and used as a label in immunoassays using luciferin as the substrate for detection. One particular advantage to the enzyme is that there is low endogenous luciferase activity in mammalian tissues besides its high sensitivity. Through the utilization of ATP, the reaction can be further used to indicate the presence of energy or life in order to function as a life-death stain. Luciferin is a common reagent used throughout the biotechnology field and specifically for in vivo imaging. Luciferase labeled tumor cells, stem cells or infectious diseases are often inoculated into research animals such as rats or mice for investigation. The injection of luciferin allows for the real-time, non-invasive monitoring of disease progression and/or drug efficacy in these model systems through Bioluminescence Imaging (BLI). Luciferin is also commonly used for in vitro research, including luciferase and ATP assays, gene reporter assays, high throughput sequencing and various contamination assays (e.g. determine cell viability and bacteria counting).

      SKU: L0009
      • Additional information

      Additional information

      Synonyms

      (S)-2-(6-Hydroxy-2-benzothiazolyl)-2-thiazoline-4-carboxylic acid potassium salt, 4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid potassium salt, Firefly luciferin potassium salt

      Purity

      ≥95% (HPLC)

      Appearance

      Light yellow solid

      CAS-Number

      115144-35-9

      Molecular Formula

      C11H7KN2O3S2

      Molecular Weight

      318.41

      Identity

      1H-NMR

      Solvents

      DMSO (10 mg/ml), water (10 mg/ml)

      Smiles

      OC1=CC=C2C(SC(C3=N[C@@H](C([O-])=O)CS3)=N2)=C1.[K+]

      InChi Key

      UMBKGTQQGYPQBE-OGFXRTJISA-M

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Very light-sensitive. Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) V.T. Nguyen, et al., Anal. Biochem. 171, 404 (1988), (2) S.P. Crouch, et al., J. Immunol. Methods 160, 81 (1993), (3) N. Lembert, Biochem. J. 317, 273 (1996), (4) S.R. Ford, et al., Methods Mol. Biol. 102, 3 (1998), (5) J.D. Day, et al., Luminescence 19, 8 (2004) (Review), (6) V.R. Viviani & Y. Ohmiya, Luminescence 21, 262 (2006), (7) M.L. Schipper, et al., Mol. Imaging Biol. 8, 218 (2006), (8) S. Palomba, et al., Langmuir 22, 5451 (2006), (9) S.T. Adams & S.C. Miller, Curr. Opin. Chem. Biol. 21, 112 (2014) (Review), (10) T. Ishimoto, et al., J. Biol. Pharm. Bull. 2015, 1969 (2015), (11) M. Kiyama, et al., Curr. Top. Med. Chem. 16, 2648 (2016) (Review)

      InChi

      InChI=1S/C11H8N2O3S2.K/c14-5-1-2-6-8(3-5)18-10(12-6)9-13-7(4-17-9)11(15)16, /h1-3,7,14H,4H2,(H,15,16), /q, +1/p-1/t7-, /m1./s1

      Quantity

      50 mg, 250 mg, Bulk

      © Copyright - Chemodex Ltd. - Customized Molecules developed in Switzerland
      • Home
      • All products
      • Order and delivery information
      • Disclaimer
      • Privacy policy
      • About this site
      1(E)-Iodo-oct-1-ene 1(E)-Iodo-oct-1-ene Bis(trifluoromethane)sulfonimide lithium salt Bis(trifluoromethane)sulfonimide lithium salt Scroll to top