D-(-)-Ribose

SKU: R0065

Category: Carbohydrates

Synonyms: (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal; 50-69-1
CAS-Number: C₅H₁₀O₅
Molecular Formula: 150.13
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Optical Activity: [α]20/D -18.0° to -22.0°
Melting Point: 88-92 °C (lit.)
Solvents: water

Shipping: AMBIENT
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.
Handling Advice: Protect from light and moisture.
Long Term Storage: +4°C
Short Term Storage: RT

Transportation: Not dangerous goods

Description: Aldopentose monosaccharide that is phosphorylated into D-ribose 5-phosphate by ribokinase. D-ribose-5-phosphate supports the biosynthesis of the amino acids tryptophan and histidine, and is a component in the pentose phosphate pathway. D-ribose is present in all living cells and their microenvironments and is a key component of numerous biomolecules involved in many important metabolic pathways. It also participates in the glycation of proteins producing advanced glycation end products (AGEs) that lead to cell dysfunction and death. Ribosylation, has been shown to cause protein aggregation in vitro and in vivo. Has demonstrated significant enhancing abilities in replenishing deficient cellular energy levels following myocardial ischemia, improving depressed function in numerous animal investigations and showing cellular protection during oxidative stress. D-Ribose is used as a supplement in cell culture and as a building block for synthesis.
InChi: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5-/m0/s1
References: L.M. Shecterle, et al., Recent Pat. Cardiovasc. Drug Discov. 5, 138 (2010) , P. Addis, et al., J. Diet. Suppl. 9, 178 (2012) , Y. Wei, et al., Biochim. Biophys. Acta 1820, 488 (2012) , N. Minakawa & A. Matsuda, Curr. Protoc. Nucleic Acid Chem. 59, 14 (2014)
InChi Key: PYMYPHUHKUWMLA-LMVFSUKVSA-N
Smiles: O=C([H])[C@@H]([C@@H]([C@@H](CO)O)O)O

Aldopentose monosaccharide that is phosphorylated into D-ribose 5-phosphate by ribokinase. D-ribose-5-phosphate supports the biosynthesis of the amino acids tryptophan and histidine, and is a component in the pentose phosphate pathway. D-ribose is present in all living cells and their microenvironments and is a key component of numerous biomolecules involved in many important metabolic pathways. It also participates in the glycation of proteins producing advanced glycation end products (AGEs) that lead to cell dysfunction and death. Ribosylation, has been shown to cause protein aggregation in vitro and in vivo. Has demonstrated significant enhancing abilities in replenishing deficient cellular energy levels following myocardial ischemia, improving depressed function in numerous animal investigations and showing cellular protection during oxidative stress. D-Ribose is used as a supplement in cell culture and as a building block for synthesis.

SKU: R0065 Category: Carbohydrates

Additional information

Additional information

Synonyms	(2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	50-69-1
Molecular Formula	C5H10O5
Molecular Weight	150.13
Identity	1H-NMR
Solvents	water
Melting Point	88-92 °C (lit.)
Optical Activity	[α]20/D -18.0° to -22.0°
Smiles	O=C([H])[C@@H]([C@@H]([C@@H](CO)O)O)O
InChi Key	PYMYPHUHKUWMLA-LMVFSUKVSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Transportation	Not dangerous goods
References	L.M. Shecterle, et al., Recent Pat. Cardiovasc. Drug Discov. 5, 138 (2010), P. Addis, et al., J. Diet. Suppl. 9, 178 (2012), Y. Wei, et al., Biochim. Biophys. Acta 1820, 488 (2012), N. Minakawa & A. Matsuda, Curr. Protoc. Nucleic Acid Chem. 59, 14 (2014)
InChi	InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5-/m0/s1
Quantity	25 g, 100 g, 250 g, Bulk