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D-(-)-Salicin

SKU: S0001

Category: Carbohydrates

Synonyms: D-(-)-Salicin , 2-(Hydroxymethyl)phenyl-&beta-D-glucopyranoside , Salicoside , Salicyl alcohol glucoside , Saligenin β-D-glucoside , NSC 5751; 138-52-3
CAS-Number: C₁₃H₁₈O₇
Molecular Formula: 286.28
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥99% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: water (10 mg/ml), DMSO (20 mg/ml), DMF (30 mg/ml)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: RT
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at RT.

Transportation: Not dangerous goods

Description: Salicin is an alcoholic β,-glucoside derived from willow bark that produces antioxidant and anti-inflammatory (including analgesic and antipyretic) effects very similar to that of aspirin. It acts as a non-selective COX inhibitor for COX-1 and COX-2. It has been used in the treatment of rheumatism. Shown to inhibit angiogenesis by blocking the ROS-ERK pathways and to have in vivo anticancer activity.
Smiles: C1=CC=C(C(=C1)CO)OC2C(C(C(C(O2)CO)O)O)O
InChi Key: NGFMICBWJRZIBI-UJPOAAIJSA-N
References: (1) T. Maclagan, Br. Med. J. 1, 627 (1876) , (2) T.D. Warner, et al., PNAS 96, 7563 (1999) , (3) I. Wagner & L. Heide, J. Rheumatol. 30, 1125 (2003) , (4) A.L. Blobaum & L.J. Marnett, J. Med. Chem. 50, 1425 (2007) , (5) N. Verma, et al., Inflamm. Res. 63, 161 (2014) , (6) C.S. Kong, et al., Phytother. Res. 28, 1246 (2014) , (7) Y. Li, et al., Int. Immunopharmacol. 26, 286 (2015) , (8) M. Sabaa, et al., Naunyn Schmiedebergs Arch. Pharmacol. 390, 1061 (2017)

Salicin is an alcoholic β,-glucoside derived from willow bark that produces antioxidant and anti-inflammatory (including analgesic and antipyretic) effects very similar to that of aspirin. It acts as a non-selective COX inhibitor for COX-1 and COX-2. It has been used in the treatment of rheumatism. Shown to inhibit angiogenesis by blocking the ROS-ERK pathways and to have in vivo anticancer activity.

SKU: S0001 Category: Carbohydrates

Additional information

Additional information

Synonyms	D-(-)-Salicin, 2-(Hydroxymethyl)phenyl-&beta-D-glucopyranoside, Salicoside, Salicyl alcohol glucoside, Saligenin β-D-glucoside, NSC 5751
Purity	≥99% (HPLC)
Appearance	White to off-white powder
CAS-Number	138-52-3
Molecular Formula	C13H18O7
Molecular Weight	286.28
Identity	1H-NMR
Solvents	water (10 mg/ml), DMSO (20 mg/ml), DMF (30 mg/ml)
Smiles	C1=CC=C(C(=C1)CO)OC2C(C(C(C(O2)CO)O)O)O
InChi Key	NGFMICBWJRZIBI-UJPOAAIJSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Transportation	Not dangerous goods
References	(1) T. Maclagan, Br. Med. J. 1, 627 (1876), (2) T.D. Warner, et al., PNAS 96, 7563 (1999), (3) I. Wagner & L. Heide, J. Rheumatol. 30, 1125 (2003), (4) A.L. Blobaum & L.J. Marnett, J. Med. Chem. 50, 1425 (2007), (5) N. Verma, et al., Inflamm. Res. 63, 161 (2014), (6) C.S. Kong, et al., Phytother. Res. 28, 1246 (2014), (7) Y. Li, et al., Int. Immunopharmacol. 26, 286 (2015), (8) M. Sabaa, et al., Naunyn Schmiedebergs Arch. Pharmacol. 390, 1061 (2017)
Quantity	25 g, 100 g, Bulk