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    Dansylcadaverine

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      Dansylcadaverine

      SKU
      D0189

      Category: Fluorescent Detection

      Synonyms
      MDC , Monodansyl cadaverine , N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide , N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine
      10121-91-2
      CAS-Number
      C17H25N3O2S
      Molecular Formula
      335.46
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥95% (HPLC)
      Appearance
      Off-white solid

      Properties

      Solvents
      methanol, DMSO
      Long Term Storage
      -20°C
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Handling Advice
      Protect from light and moisture.
      Short Term Storage
      -20°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      Fluorescent probe for derivatization of aldehydes, ketones and carboxylic acids. Used to prepare small fluorescent biomolecules via amidation or reductive amination. Used to monitor autophagy. Functions by marking the autophagosomes, which allows researchers to follow the molecular components of the process throughout. Accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids. Has biological applications in measuring cardiac autophagic flux, studying Parkinson's disease, peritoneal ovarian tumor dissemination and respiratory diseases. This fluorescent tag is preferred over other due to its specificity and simplicity in detecting autophagic vesicles. Fluorescent substrate for assaying transamidating enzymes. Shown to inhibit endocytosis, the fibrin-stabilizing factor and epidermal growth factor (EGF) internalization. Dansyl dyes have environmentally sensitive fluorescence quantum yields and emission maxima along with large stokes shifts. Spectral Data: λex 335nm, λem518 nm in methanol.
      InChi
      InChI=1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
      References
      (1) L. Lorand, et al., Anal. Biochem. 93, 453 (1979) , (2) H.T. Haigler, et al., J. Biol. Chem. 255, 1239 (1980) , (3) R.R. Hantgan, Biochemistry 21, 1821 (1982) , (4) E. Perez-Paya, et al., FEBS Lett. 278, 51 (1991) , (5) C.M. Gomez, et al., Int. J. Biol. Macromol. 27, 291 (2000) , (6) D.B. Munafo & M.I. Colombo, J Cell Sci. 114, 3619 (2001) , (7) A. Campisi, et al., Brain. Res. 978, 24 (2003) , (8) Y. Deguchi, et al., Neurochem. 84, 1154 (2003) , (9) R.W. Sabnis, Handbook of biological dyes and stains (2010)
      InChi Key
      MLEBFEHOJICQQS-UHFFFAOYSA-N
      Smiles
      CN(C)C1=C(C=CC=C2S(NCCCCCN)(=O)=O)C2=CC=C1

      Fluorescent probe for derivatization of aldehydes, ketones and carboxylic acids. Used to prepare small fluorescent biomolecules via amidation or reductive amination. Used to monitor autophagy. Functions by marking the autophagosomes, which allows researchers to follow the molecular components of the process throughout. Accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids. Has biological applications in measuring cardiac autophagic flux, studying Parkinson’s disease, peritoneal ovarian tumor dissemination and respiratory diseases. This fluorescent tag is preferred over other due to its specificity and simplicity in detecting autophagic vesicles. Fluorescent substrate for assaying transamidating enzymes. Shown to inhibit endocytosis, the fibrin-stabilizing factor and epidermal growth factor (EGF) internalization. Dansyl dyes have environmentally sensitive fluorescence quantum yields and emission maxima along with large stokes shifts. Spectral Data: λex 335nm, λem518 nm in methanol.

      SKU: D0189 Category: Fluorescent Detection
      • Additional information

      Additional information

      Synonyms

      MDC, Monodansyl cadaverine, N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide, N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine

      Purity

      ≥95% (HPLC)

      Appearance

      Off-white solid

      CAS-Number

      10121-91-2

      Molecular Formula

      C17H25N3O2S

      Molecular Weight

      335.46

      Solvents

      methanol, DMSO

      Smiles

      CN(C)C1=C(C=CC=C2S(NCCCCCN)(=O)=O)C2=CC=C1

      InChi Key

      MLEBFEHOJICQQS-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      -20°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) L. Lorand, et al., Anal. Biochem. 93, 453 (1979), (2) H.T. Haigler, et al., J. Biol. Chem. 255, 1239 (1980), (3) R.R. Hantgan, Biochemistry 21, 1821 (1982), (4) E. Perez-Paya, et al., FEBS Lett. 278, 51 (1991), (5) C.M. Gomez, et al., Int. J. Biol. Macromol. 27, 291 (2000), (6) D.B. Munafo & M.I. Colombo, J Cell Sci. 114, 3619 (2001), (7) A. Campisi, et al., Brain. Res. 978, 24 (2003), (8) Y. Deguchi, et al., Neurochem. 84, 1154 (2003), (9) R.W. Sabnis, Handbook of biological dyes and stains (2010)

      InChi

      InChI=1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3

      Quantity

      250 mg, Bulk

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