Specifications
- Purity
- ≥98% (NMR)
- Appearance
- Off-white solid
Properties
- Solvents
- methanol, DMSO
Available from stock
Dansylcadaverine
- SKU
- D0189
Category: Fluorescent Detection
- Synonyms
- MDC , Monodansyl cadaverine , N-(5-Aminopentyl)-5-dimethylaminonaphthalene-1-sulfonamide , N-(Dimethylaminonaphthalenesulfonyl)-1,5-pentanediamine
- 10121-91-2
- CAS-Number
- C17H25N3O2S
- Molecular Formula
- 335.46
- Molecular Weight
- Long Term Storage
- -20°C
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Handling Advice
- Protect from light and moisture.
- Short Term Storage
- -20°C
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Description
- Fluorescent probe for derivatization of aldehydes, ketones and carboxylic acids. Used to prepare small fluorescent biomolecules via amidation or reductive amination. Used to monitor autophagy. Functions by marking the autophagosomes, which allows researchers to follow the molecular components of the process throughout. Accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids. Has biological applications in measuring cardiac autophagic flux, studying Parkinson's disease, peritoneal ovarian tumor dissemination and respiratory diseases. This fluorescent tag is preferred over other due to its specificity and simplicity in detecting autophagic vesicles. Fluorescent substrate for assaying transamidating enzymes. Shown to inhibit endocytosis, the fibrin-stabilizing factor and epidermal growth factor (EGF) internalization. Dansyl dyes have environmentally sensitive fluorescence quantum yields and emission maxima along with large stokes shifts. Spectral Data: λex 335nm, λem518 nm in methanol.
- InChi
- InChI=1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
- References
- (1) L. Lorand, et al., Anal. Biochem. 93, 453 (1979) , (2) H.T. Haigler, et al., J. Biol. Chem. 255, 1239 (1980) , (3) R.R. Hantgan, Biochemistry 21, 1821 (1982) , (4) E. Perez-Paya, et al., FEBS Lett. 278, 51 (1991) , (5) C.M. Gomez, et al., Int. J. Biol. Macromol. 27, 291 (2000) , (6) D.B. Munafo & M.I. Colombo, J Cell Sci. 114, 3619 (2001) , (7) A. Campisi, et al., Brain. Res. 978, 24 (2003) , (8) Y. Deguchi, et al., Neurochem. 84, 1154 (2003) , (9) R.W. Sabnis, Handbook of biological dyes and stains (2010)
- InChi Key
- MLEBFEHOJICQQS-UHFFFAOYSA-N
- Smiles
- CN(C)C1=C(C=CC=C2S(NCCCCCN)(=O)=O)C2=CC=C1
Fluorescent probe for derivatization of aldehydes, ketones and carboxylic acids. Used to prepare small fluorescent biomolecules via amidation or reductive amination. Used to monitor autophagy. Functions by marking the autophagosomes, which allows researchers to follow the molecular components of the process throughout. Accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids. Has biological applications in measuring cardiac autophagic flux, studying Parkinson’s disease, peritoneal ovarian tumor dissemination and respiratory diseases. This fluorescent tag is preferred over other due to its specificity and simplicity in detecting autophagic vesicles. Fluorescent substrate for assaying transamidating enzymes. Shown to inhibit endocytosis, the fibrin-stabilizing factor and epidermal growth factor (EGF) internalization. Dansyl dyes have environmentally sensitive fluorescence quantum yields and emission maxima along with large stokes shifts. Spectral Data: λex 335nm, λem518 nm in methanol.
Additional information
| Synonyms | MDC, Monodansyl cadaverine, N-(5-Aminopentyl)-5-dimethylaminonaphthalene-1-sulfonamide, N-(Dimethylaminonaphthalenesulfonyl)-1,5-pentanediamine |
|---|---|
| Purity | ≥98% (NMR) |
| Appearance | Off-white solid |
| CAS-Number | 10121-91-2 |
| Molecular Formula | C17H25N3O2S |
| Molecular Weight | 335.46 |
| Solvents | methanol, DMSO |
| Smiles | CN(C)C1=C(C=CC=C2S(NCCCCCN)(=O)=O)C2=CC=C1 |
| InChi Key | MLEBFEHOJICQQS-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) L. Lorand, et al., Anal. Biochem. 93, 453 (1979), (2) H.T. Haigler, et al., J. Biol. Chem. 255, 1239 (1980), (3) R.R. Hantgan, Biochemistry 21, 1821 (1982), (4) E. Perez-Paya, et al., FEBS Lett. 278, 51 (1991), (5) C.M. Gomez, et al., Int. J. Biol. Macromol. 27, 291 (2000), (6) D.B. Munafo & M.I. Colombo, J Cell Sci. 114, 3619 (2001), (7) A. Campisi, et al., Brain. Res. 978, 24 (2003), (8) Y. Deguchi, et al., Neurochem. 84, 1154 (2003), (9) R.W. Sabnis, Handbook of biological dyes and stains (2010) |
| InChi | InChI=1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3 |
| Quantity | 250 mg, Bulk |
