Available from stock

Dexamethasone

SKU: D0359

Category: Antibiotics

Synonyms: MK-125, NSC 34521, 9&alpha,-Fluoro-16&alpha,-methylprednisolone,; 50-02-2
CAS-Number: C₂₂H₂₉FO₅
Molecular Formula: 392.46
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: Soluble in DMSO (25mg/ml), ethanol (20mg/ml) or chloroform.
Melting Point: 262-264 °C (lit.)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H360FD
Precautionary statements: P201 - P202 - P280 - P308 + P313 - P405 - P501
GHS Symbol: GHS08
Signal word: Danger
Transportation: Not dangerous goods

Description: Dexamethasone is a potent anti-inflammatory and immunosuppressive agent useful in a variety of inflammatory and autoimmune conditions. This synthetic glucocorticoid acts as an agonist of human glucocorticoid receptor (GR) and binds with a higher affinity than the natural ligand cortisol. Through GR activation, dexamethasone has both transactivating and transrepressing effects on gene expression, resulting in anti-inflammatory properties. The anti-inflammatory effects are complex, but primarily via inhibition of inflammatory cells and suppression of expression of inflammatory mediators.
Smiles: O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(CO)=O)=C1
InChi Key: UREBDLICKHMUKA-CXSFZGCWSA-N
References: (1) M.A. Clark, et al.; Prostaglandins 32, 703 (1986) , (2) R. Matasic, et al.; J. Leukoc. Biol. 66, 909 (1999) , (3) I. Rahman; Biochem. Pharmacol. 60, 1041 (2000) , (4) I.M. Beck, et al.; Endocr. Rev. 30, 830 (2009) , (5) C. van Kooten, et al.; Handb. Exp. Pharmacol. 2009, 233 (2009) , (6) I.S. Okoye, et al.; Cancer Immunol. Immunother. (Epub ahead of print) (2020)
InChi: InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

Dexamethasone is a potent anti-inflammatory and immunosuppressive agent useful in a variety of inflammatory and autoimmune conditions. This synthetic glucocorticoid acts as an agonist of human glucocorticoid receptor (GR) and binds with a higher affinity than the natural ligand cortisol. Through GR activation, dexamethasone has both transactivating and transrepressing effects on gene expression, resulting in anti-inflammatory properties. The anti-inflammatory effects are complex, but primarily via inhibition of inflammatory cells and suppression of expression of inflammatory mediators.

SKU: D0359 Category: Antibiotics

Additional information

Additional information

Synonyms	MK-125, NSC 34521, 9&alpha,-Fluoro-16&alpha,-methylprednisolone,
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	50-02-2
Molecular Formula	C22H29FO5
Molecular Weight	392.46
Identity	1H-NMR
Solvents	Soluble in DMSO (25mg/ml), ethanol (20mg/ml) or chloroform.
Melting Point	262-264 °C (lit.)
Smiles	O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(CO)=O)=C1
InChi Key	UREBDLICKHMUKA-CXSFZGCWSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H360FD
Precautionary statements	P201 – P202 – P280 – P308 + P313 – P405 – P501
GHS Symbol	GHS08
Signal word	Danger
Transportation	Not dangerous goods
References	(1) M.A. Clark, et al.; Prostaglandins 32, 703 (1986), (2) R. Matasic, et al.; J. Leukoc. Biol. 66, 909 (1999), (3) I. Rahman; Biochem. Pharmacol. 60, 1041 (2000), (4) I.M. Beck, et al.; Endocr. Rev. 30, 830 (2009), (5) C. van Kooten, et al.; Handb. Exp. Pharmacol. 2009, 233 (2009), (6) I.S. Okoye, et al.; Cancer Immunol. Immunother. (Epub ahead of print) (2020)
InChi	InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
Quantity	500 mg, 1 g, Bulk