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    DIB-Cl

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      DIB-Cl

      SKU
      D0009

      Categories: Fluorescent Detection, Fluorescent Detection

      Synonyms
      4-(4,5-Diphenyl-imidazol-2-yl)benzoyl-chloride
      162756-62-9
      CAS-Number
      C22H15ClN2O
      Molecular Formula
      358.82
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥95% (HPLC)
      Appearance
      White to off-white powder
      Identity
      1H-NMR

      Properties

      Solvents
      acetonitrile
      Fluorescence
      λex 335 nm, λem 420 nm in chloroform (after derivatization with hexylamine)

      Documentation

      Safety Data Sheet (SDS)
      CDX D0009 MSDS.pdf
      Shipping
      AMBIENT
      Short Term Storage
      +4°C
      Long Term Storage
      -20°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Hazard statements
      H315, H319, H335
      Precautionary statements
      P261, P305 + P351 + P338
      GHS Symbol
      GHS07
      Signal word
      Warning
      Transportation
      Not dangerous goods
      Description
      4-(4,5-diphenyl-1H-imidazol-2-yl)benzoyl chloride (DIB-Cl) as reagent for amine labelling was used successfully for derivatization and fluorescence detection of enantiomers of methamphetamin and p-hydroxymethamphetamin, in urine samples. It has also been used for 3,4-Methylendioxy-N-methylamphetamin in blood, morpholine and orther compounds. DIB-Cl as a label was used on fluorescent derivatization some hydroxyl group containing endocrine disruptors, including bisphenol A (BPA), bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF) and 4-nonylphenol (4-NP). DIB-Cl showed superior fluorescence intensity (FI) to other commercially available reagents, excellent stability in solution and high reactivity with primary and secondary amines under mild conditions.
      Smiles
      ClC(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=CC=C1)C1=CC=CC=C1
      InChi Key
      PHMRAWURTKPWFB-UHFFFAOYSA-N
      References
      (1) M. Wada et al.: Anal. Bioanal. Chem. 391(3), 1057 (2008) , (2) M. Tomita et al.: Biomed. Chromatogr. 20(12), 1380 (2006) , (3) Y. Sun et al.: Analyt. Sci. 17, 697 (2001) , (4) O. Al-Dirbashi et al.: J. Chtomatogr. B 712, 105 (1998)
      InChi
      InChI=1S/C22H15ClN2O/c23-21(26)17-11-13-18(14-12-17)22-24-19(15-7-3-1-4-8-15)20(25-22)16-9-5-2-6-10-16/h1-14H,(H,24,25)

      4-(4,5-diphenyl-1H-imidazol-2-yl)benzoyl chloride (DIB-Cl) as reagent for amine labelling was used successfully for derivatization and fluorescence detection of enantiomers of methamphetamin and p-hydroxymethamphetamin, in urine samples. It has also been used for 3,4-Methylendioxy-N-methylamphetamin in blood, morpholine and orther compounds. DIB-Cl as a label was used on fluorescent derivatization some hydroxyl group containing endocrine disruptors, including bisphenol A (BPA), bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF) and 4-nonylphenol (4-NP). DIB-Cl showed superior fluorescence intensity (FI) to other commercially available reagents, excellent stability in solution and high reactivity with primary and secondary amines under mild conditions.

      SKU: D0009 Categories: Fluorescent Detection, Fluorescent Detection
      • Additional information

      Additional information

      Synonyms

      4-(4,5-Diphenyl-imidazol-2-yl)benzoyl-chloride

      Purity

      ≥95% (HPLC)

      Appearance

      White to off-white powder

      CAS-Number

      162756-62-9

      Molecular Formula

      C22H15ClN2O

      Molecular Weight

      358.82

      Identity

      1H-NMR

      Solvents

      acetonitrile

      Fluorescence

      λex 335 nm, λem 420 nm in chloroform (after derivatization with hexylamine)

      Smiles

      ClC(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=CC=C1)C1=CC=CC=C1

      InChi Key

      PHMRAWURTKPWFB-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Hazard statements

      H315, H319, H335

      Precautionary statements

      P261, P305 + P351 + P338

      GHS Symbol

      GHS07

      Signal word

      Warning

      Transportation

      Not dangerous goods

      References

      (1) M. Wada et al.: Anal. Bioanal. Chem. 391(3), 1057 (2008), (2) M. Tomita et al.: Biomed. Chromatogr. 20(12), 1380 (2006), (3) Y. Sun et al.: Analyt. Sci. 17, 697 (2001), (4) O. Al-Dirbashi et al.: J. Chtomatogr. B 712, 105 (1998)

      InChi

      InChI=1S/C22H15ClN2O/c23-21(26)17-11-13-18(14-12-17)22-24-19(15-7-3-1-4-8-15)20(25-22)16-9-5-2-6-10-16/h1-14H,(H,24,25)

      Quantity

      200 mg, 1 g, Bulk

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