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    Dihydrofluorescein diacetate

    Available from stock

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      Dihydrofluorescein diacetate

      SKU
      D0122

      Categories: Fluorescent Detection, Fluorescent Detection

      Synonyms
      Diacetyldihydrofluorescein
      35340-49-9
      CAS-Number
      C24H18O7
      Molecular Formula
      418.4
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥97% (NMR)
      Identity
      1H-NMR
      Appearance
      Yellow powder

      Properties

      Fluorescence
      λex 272 nm in methanol, λex 490, λem 514 (Reaction product)
      Melting Point
      212-215 °C
      Solvents
      chloroform

      Downloads

      Safety Data Sheet
      CDX D0122 MSDS.pdf
      Shipping
      AMBIENT
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      -20°C
      Short Term Storage
      +4°C
      Transportation
      Not dangerous goods
      Description
      Dihydrofluorescein diacetate is a fluorescent probe for detecting intracellular oxidants. It is hydrolyzed by cellular esterases to dihydrofluorescein and is then oxidized to fluorescein primarily by H2O2. Dihydrofluorescein diacetate might be reactive toward a broad range of oxidizing reactions that may be increased during intracellular oxidant stress. Cell-loading studies indicate that dihydrofluorescein achieves higher intracellular concentrations than the other redox sensors such as Dihydrorhodamine 123 (Ex/Em: 490/514nm).
      InChi
      InChI=1S/C24H18O7/c1-13(25)29-15-7-9-19-21(11-15)31-22-12-16(30-14(2)26)8-10-20(22)23(19)17-5-3-4-6-18(17)24(27)28/h3-12,23H,1-2H3,(H,27,28)
      References
      (1) P.P. Williams & R.L. Stolzenberg: Applied Microbiology 23(4), 745-9 (1972) , (2) S.L. Hempel, et al.: Free Radical Biology & Medicine 27(1/2), 146-159 (1999) , (3) Y. O'Malley et al.: Free Radical Biology & Medicine 36(1), 90-100 (2004)
      InChi Key
      YKSJJXGQHSESKB-UHFFFAOYSA-N
      Smiles
      CC(=O)OC1=CC2=C(C=C1)C(C1=C(O2)C=C(OC(C)=O)C=C1)C1=C(C=CC=C1)C(O)=O

      Dihydrofluorescein diacetate is a fluorescent probe for detecting intracellular oxidants. It is hydrolyzed by cellular esterases to dihydrofluorescein and is then oxidized to fluorescein primarily by H2O2. Dihydrofluorescein diacetate might be reactive toward a broad range of oxidizing reactions that may be increased during intracellular oxidant stress. Cell-loading studies indicate that dihydrofluorescein achieves higher intracellular concentrations than the other redox sensors such as Dihydrorhodamine 123 (Ex/Em: 490/514nm).

      SKU: D0122 Categories: Fluorescent Detection, Fluorescent Detection
      • Additional information

      Additional information

      Synonyms

      Diacetyldihydrofluorescein

      Purity

      ≥97% (NMR)

      Appearance

      Yellow powder

      CAS-Number

      35340-49-9

      Molecular Formula

      C24H18O7

      Molecular Weight

      418.4

      Identity

      1H-NMR

      Solvents

      chloroform

      Melting Point

      212-215 °C

      Fluorescence

      λex 272 nm in methanol, λex 490, λem 514 (Reaction product)

      Smiles

      CC(=O)OC1=CC2=C(C=C1)C(C1=C(O2)C=C(OC(C)=O)C=C1)C1=C(C=CC=C1)C(O)=O

      InChi Key

      YKSJJXGQHSESKB-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) P.P. Williams & R.L. Stolzenberg: Applied Microbiology 23(4), 745-9 (1972), (2) S.L. Hempel, et al.: Free Radical Biology & Medicine 27(1/2), 146-159 (1999), (3) Y. O'Malley et al.: Free Radical Biology & Medicine 36(1), 90-100 (2004)

      InChi

      InChI=1S/C24H18O7/c1-13(25)29-15-7-9-19-21(11-15)31-22-12-16(30-14(2)26)8-10-20(22)23(19)17-5-3-4-6-18(17)24(27)28/h3-12,23H,1-2H3,(H,27,28)

      Quantity

      1 g, 10 g, Bulk

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