• Home
Results for {phrase} ({results_count} of {results_count_total})
Displaying {results_count} results of {results_count_total}

More results...

Filter by Product categories
Bioactive Molecules
Amino Acids, Peptides, Proteins
Carbohydrates
Lipids, Fatty Acids
Metabolites
Phytochemicals
Vitamins
Bioactive Small Molecules
Biopolymers
Detection in Bioanalysis
Fluorescent Detection
Organic Pollutants & Pesticides
Fungicides
Herbicides
Insecticides
Other Pollutants
Pharmaceutically Actives
Antibiotics
API's & Intermediates
Steroids
Reagents and Building Blocks
Reagents for Life Sciences
Buffers
Building Blocks, Intermediates, Reagents
Fluorescent Detection
Linker
Non Fluorescent Detection & Chromogene Detection
Quorum Sensing
Uncategorized
    Industriestrasse 15, CH-9015 St. Gallen, Tel: +41 71 244 48 25
    • 0Shopping Cart
    Chemodex
    • Home
    • Products
    • Catalogs
    • About Chemodex
    • Contact & Distributors
    • Menu Menu
    Dihydrorhodamine 123

    Available from stock

      Inquiry

      Please fill out the form for your inquiry:



      * required field

      Dihydrorhodamine 123

      SKU
      D0134

      Categories: Fluorescent Detection, Fluorescent Detection

      Synonyms
      DHR
      109244-58-8
      CAS-Number
      C21H18N2O3
      Molecular Formula
      346.38
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥95% (NMR)
      Appearance
      Pink solid
      Identity
      1H-NMR

      Properties

      Solvents
      DMSO (5 mg/ml), DMF, chloroform, ethanol
      Fluorescence
      λex 500 nm, λem 525 nm in 0.1 M Tris pH 8.0 (after oxidizing with H2O2, peroxidase)

      Documentation

      Safety Data Sheet (SDS)
      CDX D0134 MSDS.pdf
      Shipping
      AMBIENT
      Short Term Storage
      +4°C
      Long Term Storage
      -20°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Transportation
      Not dangerous goods
      Description
      Cell-permeable non-fluorescent reactive oxygen species (ROS) indicator. Passively diffuse across membranes where it is oxidized by peroxynitrite to rhodamine 123 which localizes in the mitochondria and exhibits green fluorescence (Ex/Em wavelengths of 500 and 536 nm). Used to investigate reactive oxygen intermediates produced by human and murine phagocytes, activated rat mast cells and cultured endothelial cells. In addition, it has been used together with Fura Red calcium indicator to simultaneously measure oxidative bursts and Ca2+ fluxes in monocytes and granulocytes. Dihydrorhodamine 123 has been shown to be a more sensitive probe than H2DCFDA for detecting granulocyte respiratory bursts.
      Smiles
      COC(=O)C1=CC=CC=C1C1C2=CC=C(N)C=C2OC2=C1C=CC(N)=C2
      InChi Key
      FNEZBBILNYNQGC-UHFFFAOYSA-N
      References
      (1) K. Hensley et al.: Meth. Biol. Oxidative Stress 169 (2003) , (2) H. Ischiropoulos et al.: Meth. Enzymology 301, 367 (1999) , (3) L.M. Henderson et al.: Europ. J. Biochem. FEBS 217(3), 973 (1993)
      InChi
      InChI=1S/C21H18N2O3/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20/h2-11,20H,22-23H2,1H3

      Cell-permeable non-fluorescent reactive oxygen species (ROS) indicator. Passively diffuse across membranes where it is oxidized by peroxynitrite to rhodamine 123 which localizes in the mitochondria and exhibits green fluorescence (Ex/Em wavelengths of 500 and 536 nm). Used to investigate reactive oxygen intermediates produced by human and murine phagocytes, activated rat mast cells and cultured endothelial cells. In addition, it has been used together with Fura Red calcium indicator to simultaneously measure oxidative bursts and Ca2+ fluxes in monocytes and granulocytes. Dihydrorhodamine 123 has been shown to be a more sensitive probe than H2DCFDA for detecting granulocyte respiratory bursts.

      SKU: D0134 Categories: Fluorescent Detection, Fluorescent Detection
      • Additional information

      Additional information

      Synonyms

      DHR

      Purity

      ≥95% (NMR)

      Appearance

      Pink solid

      CAS-Number

      109244-58-8

      Molecular Formula

      C21H18N2O3

      Molecular Weight

      346.38

      Identity

      1H-NMR

      Solvents

      DMSO (5 mg/ml), DMF, chloroform, ethanol

      Fluorescence

      λex 500 nm, λem 525 nm in 0.1 M Tris pH 8.0 (after oxidizing with H2O2, peroxidase)

      Smiles

      COC(=O)C1=CC=CC=C1C1C2=CC=C(N)C=C2OC2=C1C=CC(N)=C2

      InChi Key

      FNEZBBILNYNQGC-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) K. Hensley et al.: Meth. Biol. Oxidative Stress 169 (2003), (2) H. Ischiropoulos et al.: Meth. Enzymology 301, 367 (1999), (3) L.M. Henderson et al.: Europ. J. Biochem. FEBS 217(3), 973 (1993)

      InChi

      InChI=1S/C21H18N2O3/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20/h2-11,20H,22-23H2,1H3

      Quantity

      2 mg, 10 mg, 125 mg, Bulk

      Related products

      • 6-Aminofluorescein

        6-Aminofluorescein

        Purity: ≥95% (HPLC)CAS-Number: 51649-83-3SKU: A0019

        Read more Show Details
      • DAF-FM

        DAF-FM

        Purity: ≥98% (HPLC)CAS-Number: 254109-20-1SKU: A0023

        Read more Show Details
      • AMQI

        AMQI

        Purity: ≥98% (HPLC)CAS-Number: 7270-83-9SKU: A0036

        Read more Show Details
      • AMCA-H

        AMCA-H

        Purity: ≥90% (HPLC)CAS-Number: 106562-32-7SKU: A0009

        Read more Show Details
      © Copyright - Chemodex AG - Customized Molecules developed in Switzerland
      • Home
      • All products
      • Order and delivery information
      • Disclaimer
      • Privacy policy
      • About this site
      DAR-1DAR-122,3-Diaminopropane-1-thiol dihydrobromide Scroll to top