DL-3-Hydroxyisobutyric acid sodium salt
- SKU
- H0085
Category: Metabolites
- Synonyms
- (±)-Sodium β-hydroxyisobutyrate , (±)-β-HIBA-Na , 3-Hydroxy-2-methylpropionic acid sodium salt , Sodium 3-hydroxy-2-methylpropionate
- 1219589-99-7
- CAS-Number
- C4H7NaO3
- Molecular Formula
- 126.09
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Specifications
- Purity
- ≥96% (GC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, water
Documentation
- Safety Data Sheet (SDS)
- CDX H0085 MSDS.pdf
- Certificate of Analysis (Example)
- CDX H0085 CofA Y7004_Vs1.pdf
- 1H-NMR (Example)
- CDX H0085 NMR Y7004_Vs2.pdf
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Transportation
- Not dangerous goods
- Description
- Intermediate formed in the valine catabolism. It is a reactant of the enzymes involved in branched chain amino acid metabolism 3-hydroxyisobutyrate dehydrogenase and 3-hydroxyisobutyryl-CoA hydrolase and it was found to have increased concentrations in MS patient metabolic profiles. This compound may be used to study the distribution, characterization and kinetics of these enzymes. Shown to inhibit key enzymes of the energy metabolism.
- Smiles
- OCC(C)C(O[Na])=O
- InChi Key
- RBJZIQZDAZLXEK-UHFFFAOYSA-M
- References
- (1) S. Landaas , Clin. Chim. Acta 64, 143 (1975) , (2) J.W. Hawes, et al.: Methods Enzymol. 324, 218 (2000) , (3) F.J. Loupatty, et al.: Am. J. Hum. Genet. 80, 195 (2007) , (4) C.M. Viegas, et al.: Int. J. Dev. Neurosci. 26, 293 (2008) , (5) R.J. Wanders, et al.: J. Inherit. Metab. Dis. 35, 5 (2012)
- InChi
- InChI=1S/C4H8O3.Na/c1-3(2-5)4(6)7
Intermediate formed in the valine catabolism. It is a reactant of the enzymes involved in branched chain amino acid metabolism 3-hydroxyisobutyrate dehydrogenase and 3-hydroxyisobutyryl-CoA hydrolase and it was found to have increased concentrations in MS patient metabolic profiles. This compound may be used to study the distribution, characterization and kinetics of these enzymes. Shown to inhibit key enzymes of the energy metabolism.