DL-3-Hydroxyisobutyric acid sodium salt

SKU: H0085

Category: Metabolites

Synonyms: (±)-Sodium β-hydroxyisobutyrate , (±)-β-HIBA-Na , 3-Hydroxy-2-methylpropionic acid sodium salt , Sodium 3-hydroxy-2-methylpropionate; 1219589-99-7
CAS-Number: C₄H₇NaO₃
Molecular Formula: 126.09
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥96% (GC)
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Solvents: DMSO, water

Short Term Storage: +4°C
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
Handling Advice: Protect from light and moisture.
Long Term Storage: -20°C
Shipping: AMBIENT

Transportation: Not dangerous goods

Description: Intermediate formed in the valine catabolism. It is a reactant of the enzymes involved in branched chain amino acid metabolism 3-hydroxyisobutyrate dehydrogenase and 3-hydroxyisobutyryl-CoA hydrolase and it was found to have increased concentrations in MS patient metabolic profiles. This compound may be used to study the distribution, characterization and kinetics of these enzymes. Shown to inhibit key enzymes of the energy metabolism.
InChi: InChI=1S/C4H8O3.Na/c1-3(2-5)4(6)7
References: (1) S. Landaas , Clin. Chim. Acta 64, 143 (1975) , (2) J.W. Hawes, et al.: Methods Enzymol. 324, 218 (2000) , (3) F.J. Loupatty, et al.: Am. J. Hum. Genet. 80, 195 (2007) , (4) C.M. Viegas, et al.: Int. J. Dev. Neurosci. 26, 293 (2008) , (5) R.J. Wanders, et al.: J. Inherit. Metab. Dis. 35, 5 (2012)
InChi Key: RBJZIQZDAZLXEK-UHFFFAOYSA-M
Smiles: OCC(C)C(O[Na])=O

Intermediate formed in the valine catabolism. It is a reactant of the enzymes involved in branched chain amino acid metabolism 3-hydroxyisobutyrate dehydrogenase and 3-hydroxyisobutyryl-CoA hydrolase and it was found to have increased concentrations in MS patient metabolic profiles. This compound may be used to study the distribution, characterization and kinetics of these enzymes. Shown to inhibit key enzymes of the energy metabolism.

SKU: H0085 Category: Metabolites

Additional information

Additional information

Synonyms	(±)-Sodium β-hydroxyisobutyrate, (±)-β-HIBA-Na, 3-Hydroxy-2-methylpropionic acid sodium salt, Sodium 3-hydroxy-2-methylpropionate
Purity	≥96% (GC)
Appearance	White to off-white powder
CAS-Number	1219589-99-7
Molecular Formula	C4H7NaO3
Molecular Weight	126.09
Identity	1H-NMR
Solvents	DMSO, water
Smiles	OCC(C)C(O[Na])=O
InChi Key	RBJZIQZDAZLXEK-UHFFFAOYSA-M
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) S. Landaas, Clin. Chim. Acta 64, 143 (1975), (2) J.W. Hawes, et al.: Methods Enzymol. 324, 218 (2000), (3) F.J. Loupatty, et al.: Am. J. Hum. Genet. 80, 195 (2007), (4) C.M. Viegas, et al.: Int. J. Dev. Neurosci. 26, 293 (2008), (5) R.J. Wanders, et al.: J. Inherit. Metab. Dis. 35, 5 (2012)
InChi	InChI=1S/C4H8O3.Na/c1-3(2-5)4(6)7
Quantity	250 mg, 1 g, Bulk