Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml)
Available from stock
Domperidone
- SKU
- D0809
Categories:
- Synonyms
- R33812 , 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine , Motilium , NSC 299589
- 57808-66-9
- CAS-Number
- C22H24ClN5O2
- Molecular Formula
- 425.91
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Hazard statements
- H361
- Precautionary statements
- P280
- GHS Symbol
- GHS08
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- Domperidone is a peripheral dopamine D2-like receptor antagonist that does not readily cross the blood-brain barrier. It demonstrates a potent affinity for the rat D2 receptor and is also reported to inhibit the rat D3 receptor. The antidopaminergic effects are cross-realted to its gastroprokinetic and antiemetic properties.
- Smiles
- ClC1=CC2=C(C=C1)N(C1CCN(CCCN3C(=O)NC4=CC=CC=C34)CC1)C(=O)N2
- InChi Key
- FGXWKSZFVQUSTL-UHFFFAOYSA-N
- References
- (1) D.B. Wilson & J.W. Dundee, Anaesthesia 34, 765 (1979) , (2) C.J. Niemegeers, et al., Arch. Int. Pharmacodyn. Ther. 244, 130 (1980) , (3) M.C. Champion, et al., Can. Med. Assoc. J. 135, 457 (1986) , (4) C. Lin, et al., J. Pharmacol. Exper. Therap. 242, 950 (1987) , (5) P. Sokoloff, et al., Nature 137, 146 (1990) , (6) A. Prakash & A.J. Wagstaff, Drugs 56, 429 (1998) , (7) Y. Hirokawa, et al., J. Med. Chem. 46, 702 (2003) , (8) M.A. Osinski, et al., Pharmacol. Biochem. Behav. 81, 211 (2005)
Domperidone is a peripheral dopamine D2-like receptor antagonist that does not readily cross the blood-brain barrier. It demonstrates a potent affinity for the rat D2 receptor and is also reported to inhibit the rat D3 receptor. The antidopaminergic effects are cross-realted to its gastroprokinetic and antiemetic properties.
Additional information
| Synonyms | R33812, 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine, Motilium, NSC 299589 |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White powder |
| CAS-Number | 57808-66-9 |
| Molecular Formula | C22H24ClN5O2 |
| Molecular Weight | 425.91 |
| Identity | 1H-NMR |
| Solvents | DMSO (10 mg/ml) |
| Smiles | ClC1=CC2=C(C=C1)N(C1CCN(CCCN3C(=O)NC4=CC=CC=C34)CC1)C(=O)N2 |
| InChi Key | FGXWKSZFVQUSTL-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Hazard statements | H361 |
| Precautionary statements | P280 |
| GHS Symbol | GHS08 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) D.B. Wilson & J.W. Dundee, Anaesthesia 34, 765 (1979), (2) C.J. Niemegeers, et al., Arch. Int. Pharmacodyn. Ther. 244, 130 (1980), (3) M.C. Champion, et al., Can. Med. Assoc. J. 135, 457 (1986), (4) C. Lin, et al., J. Pharmacol. Exper. Therap. 242, 950 (1987), (5) P. Sokoloff, et al., Nature 137, 146 (1990), (6) A. Prakash & A.J. Wagstaff, Drugs 56, 429 (1998), (7) Y. Hirokawa, et al., J. Med. Chem. 46, 702 (2003), (8) M.A. Osinski, et al., Pharmacol. Biochem. Behav. 81, 211 (2005) |
| Quantity | 100 mg, 500 mg, Bulk |
