Specifications
- Purity
- ≥98% (T)
- Identity
- 1H-NMR
- Appearance
- White to off-white crystalline powder
Properties
- Solvents
- water (20 mg/ml)
Available from stock
Donepezil hydrochloride
- SKU
- D0437
Category: API's & Intermediates
- Synonyms
- (±)-2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride , 2,3-Dihydro-5,6-dimethoxy-2-{[1-(phenylmethyl)-4-piperidinyl]methyl}-1H-inden-1-one , E2020
- 120011-70-3
- CAS-Number
- C24H29NO3 · HCl
- Molecular Formula
- 415.95
- Molecular Weight
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Long Term Storage
- RT
- Short Term Storage
- RT
- Shipping
- AMBIENT
- Transportation
- Packing Group II
- RIDADR
- 2811 6.1
- Signal word
- Danger
- GHS Symbol
- GHS06
- Precautionary statements
- P264, P270, P301+P310+P330, P405, P501
- Hazard statements
- H300
- Description
- Potent non-competitive reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. Displays >1000-fold selectivity for acetylcholinesterase (AChE) over butyrylcholinesterase (BuChE). It is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory and behavior.
- References
- (1) H. Sugimoto, et al., J. Med. Chem. 38, 4821 (1995) , (2) E.Y. Shintani & K.M. Uchida, Am. J. Health Syst. Pharm. 54, 2805 (1997) (Review) , (3) G. Kryger, et al., Structure 7, 297 (1999) , (4) H. Sugimoto, et al., Curr. Med. Chem. 7, 303 (2000) (Review) , (5) D. Munoz-Torrero, Curr. Med. Chem. 15, 2433 (2008) (Review) , (6) H.M. Bryson & P. Benfield, Drugs Aging 10, 234 (1997) (Review)
- InChi Key
- XWAIAVWHZJNZQQ-UHFFFAOYSA-N
- Smiles
- O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC4=CC=CC=C4)CC3.Cl
Potent non-competitive reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. Displays >1000-fold selectivity for acetylcholinesterase (AChE) over butyrylcholinesterase (BuChE). It is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory and behavior.
Additional information
| Synonyms | (±)-2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride, 2,3-Dihydro-5,6-dimethoxy-2-{[1-(phenylmethyl)-4-piperidinyl]methyl}-1H-inden-1-one, E2020 |
|---|---|
| Purity | ≥98% (T) |
| Appearance | White to off-white crystalline powder |
| CAS-Number | 120011-70-3 |
| Molecular Formula | C24H29NO3 · HCl |
| Molecular Weight | 415.95 |
| Identity | 1H-NMR |
| Solvents | water (20 mg/ml) |
| Smiles | O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC4=CC=CC=C4)CC3.Cl |
| InChi Key | XWAIAVWHZJNZQQ-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Hazard statements | H300 |
| Precautionary statements | P264, P270, P301+P310+P330, P405, P501 |
| GHS Symbol | GHS06 |
| Signal word | Danger |
| RIDADR | 2811 6.1 |
| Transportation | Packing Group II |
| References | (1) H. Sugimoto, et al., J. Med. Chem. 38, 4821 (1995), (2) E.Y. Shintani & K.M. Uchida, Am. J. Health Syst. Pharm. 54, 2805 (1997) (Review), (3) G. Kryger, et al., Structure 7, 297 (1999), (4) H. Sugimoto, et al., Curr. Med. Chem. 7, 303 (2000) (Review), (5) D. Munoz-Torrero, Curr. Med. Chem. 15, 2433 (2008) (Review), (6) H.M. Bryson & P. Benfield, Drugs Aging 10, 234 (1997) (Review) |
| Quantity | 250 mg, Bulk |
