Available from stock

(-)-Epicatechin

SKU: E0231

Category: Phytochemicals

Synonyms: EC , epi-Catechin , NSC81161 , (-)-cis-3,3',4',5,7-Pentahydroxyflavane, (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol; 490-46-0
CAS-Number: C₁₅H₁₄O₆
Molecular Formula: 290.27
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: acetone:water (1:1, 10 mg/ml), DMSO (100 mM), methanol, DMF (~125 mg/ml), water (partly)
Melting Point: 240 °C (dec.)(lit.)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H315-H319-H335
Precautionary statements: P261-P305 + P351 + P338
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: Epicatechin is a natural flavonoid found in green tea. It has been reported to possess an immense antioxidant effect which contributes to its therapeutic effect in diabetes and cancer conditions. The consumption of epicatechin has been shown to reduce blood glucose levels in diabetic patients, while its anticancer effect was attributed to its antioxidant properties, antiangiogenic and direct cytotoxicity to cancer cells. The activity of Epicatechin includes the ability to interact with and neutralize reactive oxygen species (ROS), and to modulate cell signaling including the MAP kinase pathway, which is involved in cell proliferation.
Smiles: OC1=CC(O)=C(C[C@@H](O)[C@@H](C2=CC=C(O)C(O)=C2)O3)C3=C1
InChi Key: PFTAWBLQPZVEMU-UKRRQHHQSA-N
References: (1) F. Bonilla, et al., Food Chem. 66, 209 (1999) , (2) M. Suganuma, et al., Cancer Res. 59, 44 (1999) , (3) J. Terao, J. Med. Invest. 46, 159 (1999) (Review) , (4) J.Z. Xu, et al., Br. J. Nutr. 91, 873 (2004) , (5) M.H. Ravindranath, et al., Evidence-Based Compl. Altern. Med. 6, 523 (2009) , (6) C.G. Fraga & P.I. Oteiza, Free Radic. Biol. Med. 51, 813 (2011) (Review) , (7) J. Shay, et al., Oxid. Med. Cell Longev. 2015, 181260 (2015) (Review) , (8) L.A. Abdulkhaleq, et al., Vet. World 10, 869 (2017) (Review)

Epicatechin is a natural flavonoid found in green tea. It has been reported to possess an immense antioxidant effect which contributes to its therapeutic effect in diabetes and cancer conditions. The consumption of epicatechin has been shown to reduce blood glucose levels in diabetic patients, while its anticancer effect was attributed to its antioxidant properties, antiangiogenic and direct cytotoxicity to cancer cells. The activity of Epicatechin includes the ability to interact with and neutralize reactive oxygen species (ROS), and to modulate cell signaling including the MAP kinase pathway, which is involved in cell proliferation.

SKU: E0231 Category: Phytochemicals

Additional information

Additional information

Synonyms	EC, epi-Catechin, NSC81161, (-)-cis-3,3',4',5,7-Pentahydroxyflavane, (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	490-46-0
Molecular Formula	C15H14O6
Molecular Weight	290.27
Identity	1H-NMR
Solvents	acetone:water (1:1, 10 mg/ml), DMSO (100 mM), methanol, DMF (~125 mg/ml), water (partly)
Melting Point	240 °C (dec.)(lit.)
Smiles	OC1=CC(O)=C(C[C@@H](O)[C@@H](C2=CC=C(O)C(O)=C2)O3)C3=C1
InChi Key	PFTAWBLQPZVEMU-UKRRQHHQSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305 + P351 + P338
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) F. Bonilla, et al., Food Chem. 66, 209 (1999), (2) M. Suganuma, et al., Cancer Res. 59, 44 (1999), (3) J. Terao, J. Med. Invest. 46, 159 (1999) (Review), (4) J.Z. Xu, et al., Br. J. Nutr. 91, 873 (2004), (5) M.H. Ravindranath, et al., Evidence-Based Compl. Altern. Med. 6, 523 (2009), (6) C.G. Fraga & P.I. Oteiza, Free Radic. Biol. Med. 51, 813 (2011) (Review), (7) J. Shay, et al., Oxid. Med. Cell Longev. 2015, 181260 (2015) (Review), (8) L.A. Abdulkhaleq, et al., Vet. World 10, 869 (2017) (Review)
Quantity	5 mg, 25 mg, Bulk