Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- acetone:water (1:1, 10 mg/ml), DMSO (100 mM), methanol, DMF (~125 mg/ml), water (partly)
- Melting Point
- 240 °C (dec.)(lit.)
Category: Phytochemicals
Epicatechin is a natural flavonoid found in green tea. It has been reported to possess an immense antioxidant effect which contributes to its therapeutic effect in diabetes and cancer conditions. The consumption of epicatechin has been shown to reduce blood glucose levels in diabetic patients, while its anticancer effect was attributed to its antioxidant properties, antiangiogenic and direct cytotoxicity to cancer cells. The activity of Epicatechin includes the ability to interact with and neutralize reactive oxygen species (ROS), and to modulate cell signaling including the MAP kinase pathway, which is involved in cell proliferation.
Synonyms | EC, epi-Catechin, NSC81161, (-)-cis-3,3',4',5,7-Pentahydroxyflavane, (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol |
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Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 490-46-0 |
Molecular Formula | C15H14O6 |
Molecular Weight | 290.27 |
Identity | 1H-NMR |
Solvents | acetone:water (1:1, 10 mg/ml), DMSO (100 mM), methanol, DMF (~125 mg/ml), water (partly) |
Melting Point | 240 °C (dec.)(lit.) |
Smiles | OC1=CC(O)=C(C[C@@H](O)[C@@H](C2=CC=C(O)C(O)=C2)O3)C3=C1 |
InChi Key | PFTAWBLQPZVEMU-UKRRQHHQSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P305 + P351 + P338 |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) F. Bonilla, et al., Food Chem. 66, 209 (1999), (2) M. Suganuma, et al., Cancer Res. 59, 44 (1999), (3) J. Terao, J. Med. Invest. 46, 159 (1999) (Review), (4) J.Z. Xu, et al., Br. J. Nutr. 91, 873 (2004), (5) M.H. Ravindranath, et al., Evidence-Based Compl. Altern. Med. 6, 523 (2009), (6) C.G. Fraga & P.I. Oteiza, Free Radic. Biol. Med. 51, 813 (2011) (Review), (7) J. Shay, et al., Oxid. Med. Cell Longev. 2015, 181260 (2015) (Review), (8) L.A. Abdulkhaleq, et al., Vet. World 10, 869 (2017) (Review) |
Quantity | 5 mg, 25 mg, Bulk |