Specifications
- Purity
- ≥97% (T)
- Appearance
- White powder or crystal or chunks
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in water (50 mg/ml).
- Melting Point
- 112-114 °C (lit.)
Available from stock
Ethyl acetimidate hydrochloride
- SKU
- A0745
Category: Building Blocks, Intermediates, Reagents
- Synonyms
- EAH, Ethyl acetoamidate hydrochloride, Ethyl acetocarboximidate hydrochloride, Ethyl acetoimidate hydrochloride, Ethyl ethanimidate hydrochloride, Ethyl ethanimidoate hydrochloride, Ethyl iminoacetate hydrochloride
- 2208-07-3
- CAS-Number
- CH3C(=NH)OC2H5 · HCl
- Molecular Formula
- 123.58
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- Ethyl acetimidate hydrochloride is a reactive amidinating reagent commonly used for the selective modification of primary amines in biomolecules. It converts amino groups (e.g., lysine residues in proteins) into amidine derivatives under mild conditions, helping preserve protein structure while altering charge properties. This reagent is widely used in protein chemistry for studying structure-function relationships, stabilizing protein interactions, and reversible chemical modification of biomolecules. Building block for synthesis.
- Smiles
- Cl.N=C(OCC)C
- InChi Key
- WGMHMVLZFAJNOT-UHFFFAOYSA-N
- References
- (1) K.J. Sweadner, BBRC 78, 962 (1977) , (2) M. Rack, Pflugers Arch. 404, 126 (1985) , (3) S.A. Salehi, et al., Indian J. Ophthalmol. 40, 11 (1992) , (4) W.M. Keung, et al., Int. J. Pept. Protein Res. 42, 504 (1993) , (5) A.J. Ganzhorn, et al., Biochemistry 35, 10957 (1996) , (6) K. Hyodo, et al., J. Org. Chem. 87, 2959 (2022)
- InChi
- InChI=1S/C4H9NO.ClH/c1-3-6-4(2)5,/h5H,3H2,1-2H3,1H
Ethyl acetimidate hydrochloride is a reactive amidinating reagent commonly used for the selective modification of primary amines in biomolecules. It converts amino groups (e.g., lysine residues in proteins) into amidine derivatives under mild conditions, helping preserve protein structure while altering charge properties. This reagent is widely used in protein chemistry for studying structure-function relationships, stabilizing protein interactions, and reversible chemical modification of biomolecules. Building block for synthesis.
Additional information
| Synonyms | EAH, Ethyl acetoamidate hydrochloride, Ethyl acetocarboximidate hydrochloride, Ethyl acetoimidate hydrochloride, Ethyl ethanimidate hydrochloride, Ethyl ethanimidoate hydrochloride, Ethyl iminoacetate hydrochloride |
|---|---|
| Purity | ≥97% (T) |
| Appearance | White powder or crystal or chunks |
| CAS-Number | 2208-07-3 |
| Molecular Formula | CH3C(=NH)OC2H5 · HCl |
| Molecular Weight | 123.58 |
| Identity | 1H-NMR |
| Solvents | Soluble in water (50 mg/ml). |
| Melting Point | 112-114 °C (lit.) |
| Smiles | Cl.N=C(OCC)C |
| InChi Key | WGMHMVLZFAJNOT-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | (1) K.J. Sweadner, BBRC 78, 962 (1977), (2) M. Rack, Pflugers Arch. 404, 126 (1985), (3) S.A. Salehi, et al., Indian J. Ophthalmol. 40, 11 (1992), (4) W.M. Keung, et al., Int. J. Pept. Protein Res. 42, 504 (1993), (5) A.J. Ganzhorn, et al., Biochemistry 35, 10957 (1996), (6) K. Hyodo, et al., J. Org. Chem. 87, 2959 (2022) |
| InChi | InChI=1S/C4H9NO.ClH/c1-3-6-4(2)5,/h5H,3H2,1-2H3,1H |
| Quantity | 50 g, Bulk |
