Available from stock

Florfenicol

SKU: F0069

Category: Antibiotics

Synonyms: Sch 25298, (-)-Florfenicol, Aquafen, 2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide; 73231-34-2
CAS-Number: C₁₂H₁₄Cl₂FNO₄S
Molecular Formula: 358.21
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (Assay)
Appearance: White to off white crystalline
Identity: IR

Properties

Solvents: DMSO (30mg/ml), DMF (20mg/ml) or ethanol (10mg/ml)
Melting Point: 152-156°C
Optical Activity: -16°- -19°

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H361fd,H372,H410
Precautionary statements: P202 - P260 - P264 - P273 - P280 - P308 + P313
GHS Symbol: GHS08+GHS09
Signal word: Danger
RIDADR: UN3077
Transportation: Packing Group III

Description: Florfenicol is a broad-spectrum fluorinated antibiotic and a derivative of thiamphenicol and analog of chloramphenicol. Florfenicol inhibits bacterial protein synthesis by binding to the A site of the 23S rRNA in the 50S subunit of the 70S ribosome, blocking peptidyl transferase activity, and thereby preventing peptide bond formation, which makes it effective against various bacteria. It is primarily used in veterinary medicine to treat respiratory infections in cattle and swine, and to prevent Salmonella infection in poultry. Although florfenicol is primarily known for its antimicrobial activity, it also shows immunomodulatory properties, including anti-inflammatory activity, downregulating pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, suppression of innate immune responses, affect lymphocyte proliferation and immunoglobulin production, and influence TLR expression in immune cells.
Smiles: [C@@H]([C@H](NC(C(Cl)Cl)=O)CF)(O)C1=CC=C(S(C)(=O)=O)C=C1
InChi Key: AYIRNRDRBQJXIF-NXEZZACHSA-N
References: (1) H.C. Neu & K.P. Fu, Antimicrob. Agents Chemother. 18, 311 (1980) , (2) V.P. Syriopoulou, et al., Antimicrob. Agents Chemother. 19, 294 (1981) , (3) R. Graham, et al., Eur. J. Clin. Microbiol. Infect. Dis. 7, 691 (1988) , (4) M. Cannon, et al., J. Antimicrob. Chemother. 26, 307 (1990) , (5) Y. Ueda & I. Suenaga, J. Vet. Med. Sci. 57, 363 (1995) , (6) S. Priebe & S. Schwarz, Antimicrob. Agents Chemother. 47, 2703 (2003) , (7) G. Shuang, et al., Immunol. Invest. 40, 356 (2011) , (8) X. Guo, et al., Environ. Res. 244, 117934 (2024) (Review)
InChi: InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1

Florfenicol is a broad-spectrum fluorinated antibiotic and a derivative of thiamphenicol and analog of chloramphenicol. Florfenicol inhibits bacterial protein synthesis by binding to the A site of the 23S rRNA in the 50S subunit of the 70S ribosome, blocking peptidyl transferase activity, and thereby preventing peptide bond formation, which makes it effective against various bacteria. It is primarily used in veterinary medicine to treat respiratory infections in cattle and swine, and to prevent Salmonella infection in poultry. Although florfenicol is primarily known for its antimicrobial activity, it also shows immunomodulatory properties, including anti-inflammatory activity, downregulating pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, suppression of innate immune responses, affect lymphocyte proliferation and immunoglobulin production, and influence TLR expression in immune cells.

SKU: F0069 Category: Antibiotics

Additional information

Additional information

Synonyms	Sch 25298, (-)-Florfenicol, Aquafen, 2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide
Purity	≥98% (Assay)
Appearance	White to off white crystalline
CAS-Number	73231-34-2
Molecular Formula	C12H14Cl2FNO4S
Molecular Weight	358.21
Identity	IR
Solvents	DMSO (30mg/ml), DMF (20mg/ml) or ethanol (10mg/ml)
Melting Point	152-156°C
Optical Activity	-16°- -19°
Smiles	[C@@H]([C@H](NC(C(Cl)Cl)=O)CF)(O)C1=CC=C(S(C)(=O)=O)C=C1
InChi Key	AYIRNRDRBQJXIF-NXEZZACHSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H361fd,H372,H410
Precautionary statements	P202 – P260 – P264 – P273 – P280 – P308 + P313
GHS Symbol	GHS08+GHS09
Signal word	Danger
RIDADR	UN3077
Transportation	Packing Group III
References	(1) H.C. Neu & K.P. Fu, Antimicrob. Agents Chemother. 18, 311 (1980), (2) V.P. Syriopoulou, et al., Antimicrob. Agents Chemother. 19, 294 (1981), (3) R. Graham, et al., Eur. J. Clin. Microbiol. Infect. Dis. 7, 691 (1988), (4) M. Cannon, et al., J. Antimicrob. Chemother. 26, 307 (1990), (5) Y. Ueda & I. Suenaga, J. Vet. Med. Sci. 57, 363 (1995), (6) S. Priebe & S. Schwarz, Antimicrob. Agents Chemother. 47, 2703 (2003), (7) G. Shuang, et al., Immunol. Invest. 40, 356 (2011), (8) X. Guo, et al., Environ. Res. 244, 117934 (2024) (Review)
InChi	InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1
Quantity	5 g, Bulk