Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White crystalline powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in DMSO (10mg/ml), ethanol (10mg/ml), methanol or acetone.
Available from stock
Fluconazole
- SKU
- F0104
Category: Antibiotics
- Synonyms
- 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol, UK 49858, Diflucan
- 86386-73-4
- CAS-Number
- C13H12F2N6O
- Molecular Formula
- 306.27
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Hazard statements
- H302 - H360D - H362 - H412
- Precautionary statements
- P202 - P260 - P263 - P273 - P301 + P312 - P308 + P313
- GHS Symbol
- GHS07+GHS08
- Signal word
- Danger
- Transportation
- Not dangerous goods
- Description
- Fluconazole is a triazole broad-spectrum antifungal agent which is effective against most Candida spp., cryptococcus neoformans and dermatophytes. Fluconazole is an inhibitor of CYP2C19, CYP2C9 and CYP3A4. Fluconazole functions by suppressing the production of ergosterol, a vital constituent of the fungal cell membrane. By impeding ergosterol synthesis, the integrity of the fungal cell membrane is compromised, ultimately resulting in fungal death. Moreover, Fluconazole hinders the activity of cytochrome P450 enzymes.
- Smiles
- FC1=CC(F)=C(C(CN2C=NC=N2)(O)CN3N=CN=C3)C=C1
- InChi Key
- RFHAOTPXVQNOHP-UHFFFAOYSA-N
- References
- (1) M.S. Saag & W.E. Dismukes; Antimicrob. Agents Chemother. 32, 1 (1988) , (2) H. Washton; Diagn. Microbiol. Infect. Dis. 12, 229S (1989) , (3) D.W. Warnock; J. Antimicrob. Chemother. 24, 275 (1989) , (4) K. Richardson, et al.; Rev. Infect. Dis. 12, S267 (1990) , (5) S.F. Kowalsky & D.M. Dixon; Clin. Pharm. 10, 179 (1991) , (6) J.D. Morrow; Am. J. Med. Sci. 302, 129 (1991) , (7) C.M. Perry, et al.; Drugs 49, 984 (1995) , (8) M.V. Martin; J. Antimicrob. Chemother. 44, 429 (1999) , (9) N. Thamban Chandrika, et al.; Bioorg. Med. Chem. 26, 573 (2018) , (10) S. Nami, et al.; Biomed. Pharmacother. 110, 857 (2019) , (11) X. Heng, et al.; Antimicrob. Agents Chemother. 65, e02552 (2021) , (12) M.A Elzoheiry, et al.; Exp. Parasitol. 239, 108291 (2022)
- InChi
- InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
Fluconazole is a triazole broad-spectrum antifungal agent which is effective against most Candida spp., cryptococcus neoformans and dermatophytes. Fluconazole is an inhibitor of CYP2C19, CYP2C9 and CYP3A4. Fluconazole functions by suppressing the production of ergosterol, a vital constituent of the fungal cell membrane. By impeding ergosterol synthesis, the integrity of the fungal cell membrane is compromised, ultimately resulting in fungal death. Moreover, Fluconazole hinders the activity of cytochrome P450 enzymes.
Additional information
| Synonyms | 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol, UK 49858, Diflucan |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White crystalline powder |
| CAS-Number | 86386-73-4 |
| Molecular Formula | C13H12F2N6O |
| Molecular Weight | 306.27 |
| Identity | 1H-NMR |
| Solvents | Soluble in DMSO (10mg/ml), ethanol (10mg/ml), methanol or acetone. |
| Smiles | FC1=CC(F)=C(C(CN2C=NC=N2)(O)CN3N=CN=C3)C=C1 |
| InChi Key | RFHAOTPXVQNOHP-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Hazard statements | H302 – H360D – H362 – H412 |
| Precautionary statements | P202 – P260 – P263 – P273 – P301 + P312 – P308 + P313 |
| GHS Symbol | GHS07+GHS08 |
| Signal word | Danger |
| Transportation | Not dangerous goods |
| References | (1) M.S. Saag & W.E. Dismukes; Antimicrob. Agents Chemother. 32, 1 (1988), (2) H. Washton; Diagn. Microbiol. Infect. Dis. 12, 229S (1989), (3) D.W. Warnock; J. Antimicrob. Chemother. 24, 275 (1989), (4) K. Richardson, et al.; Rev. Infect. Dis. 12, S267 (1990), (5) S.F. Kowalsky & D.M. Dixon; Clin. Pharm. 10, 179 (1991), (6) J.D. Morrow; Am. J. Med. Sci. 302, 129 (1991), (7) C.M. Perry, et al.; Drugs 49, 984 (1995), (8) M.V. Martin; J. Antimicrob. Chemother. 44, 429 (1999), (9) N. Thamban Chandrika, et al.; Bioorg. Med. Chem. 26, 573 (2018), (10) S. Nami, et al.; Biomed. Pharmacother. 110, 857 (2019), (11) X. Heng, et al.; Antimicrob. Agents Chemother. 65, e02552 (2021), (12) M.A Elzoheiry, et al.; Exp. Parasitol. 239, 108291 (2022) |
| InChi | InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 |
| Quantity | 500 mg, 1 g, Bulk |
