Available from stock

Fluoxetine hydrochloride

SKU: F0141

Category: Metabolites

Synonyms: (±)-N-Methyl-&gamma , -[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride , LY-110,140 hydrochloride , Prozac®; 56296-78-7
CAS-Number: C₁₇H₁₈F₃NO · HCl
Molecular Formula: 345.79
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white solid
Identity: 1H-NMR

Properties

Solvents: water (2 mg/ml), DMSO (10 mg/ml), DMF (10 mg/ml), ethanol (5 mg/ml)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: RT
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at RT.

Hazard statements: H302 + H332-H315-H318-H336-H373-H410
Precautionary statements: P260-P280-P301 + P312 + P330-P305 + P351 + P338 + P310
GHS Symbol: GHS05+GHS07+GHS08
Signal word: Danger
RIDADR: 3077 9
Transportation: Packing Group III

Description: Fluoxetine is a cell-permeable selective serotonin reuptake inhibitor (SSRI), with preference for the serotonin transporter (Kd=0.81nM) over the norepinephrine transporter (Kd=240nM) and the dopamine transporter (Kd=3600nM). This drug works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses. It functions as an antidepressant. Fluoxetine binds also to the human 5-HT transporter and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. It has been shown to induce differentiation of neuronal precursors, enhancing neuronal characteristics. In addition, it was reported to modulate the proliferation of T-cells by increasing the Ca2+ influx and thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC) and to regulate the phosphorylation of DARPP-32 and AMPA receptors.
Smiles: FC(C1=CC=C(OC(C2=CC=CC=C2)CCNC)C=C1)(F)F.Cl
InChi Key: GIYXAJPCNFJEHY-UHFFFAOYSA-N
References: (1) P. Benfield, et al., Drugs 32, 481 (1986) , (2) D.T. Wong, et al., Life Sci. 57, 411 (1995) , (3) M. Tatsumi, et al., Eur. J. Pharmacol 340, 249 (1997) , (4) S.G. Beck, et al., J. Pharmacol. Exp. Ther. 281, 115 (1997) , (5) M.J. Owens, et al., J. Pharmacol. Exp. Ther. 283, 1305 (1997) , (6) V.A. Edgar, et al., Eur. J. Pharmacol. 372, 65 (1999) , (7) P. Bartholoma, et al., Biochem. Pharmacol. 63, 1507 (2002) , (8) J.T. Bian, et al., Eur. J. Pharmacol. 453, 159 (2002) , (9) A. Zhang, et al., J. Med. Chem. 45, 1930 (2002) , (10) P. Svenningsson, et al., PNAS 99, 3182 (2002) , (11) L. Perez-Caballero, et al., Expert Opin. Drug Discov. 9, 567 (2014)

Fluoxetine is a cell-permeable selective serotonin reuptake inhibitor (SSRI), with preference for the serotonin transporter (Kd=0.81nM) over the norepinephrine transporter (Kd=240nM) and the dopamine transporter (Kd=3600nM). This drug works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses. It functions as an antidepressant. Fluoxetine binds also to the human 5-HT transporter and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. It has been shown to induce differentiation of neuronal precursors, enhancing neuronal characteristics. In addition, it was reported to modulate the proliferation of T-cells by increasing the Ca2+ influx and thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC) and to regulate the phosphorylation of DARPP-32 and AMPA receptors.

SKU: F0141 Category: Metabolites

Additional information

Additional information

Synonyms	(±)-N-Methyl-&gamma, -[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride, LY-110,140 hydrochloride, Prozac®
Purity	≥98% (HPLC)
Appearance	White to off-white solid
CAS-Number	56296-78-7
Molecular Formula	C17H18F3NO · HCl
Molecular Weight	345.79
Identity	1H-NMR
Solvents	water (2 mg/ml), DMSO (10 mg/ml), DMF (10 mg/ml), ethanol (5 mg/ml)
Smiles	FC(C1=CC=C(OC(C2=CC=CC=C2)CCNC)C=C1)(F)F.Cl
InChi Key	GIYXAJPCNFJEHY-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Hazard statements	H302 + H332-H315-H318-H336-H373-H410
Precautionary statements	P260-P280-P301 + P312 + P330-P305 + P351 + P338 + P310
GHS Symbol	GHS05+GHS07+GHS08
Signal word	Danger
RIDADR	3077 9
Transportation	Packing Group III
References	(1) P. Benfield, et al., Drugs 32, 481 (1986), (2) D.T. Wong, et al., Life Sci. 57, 411 (1995), (3) M. Tatsumi, et al., Eur. J. Pharmacol 340, 249 (1997), (4) S.G. Beck, et al., J. Pharmacol. Exp. Ther. 281, 115 (1997), (5) M.J. Owens, et al., J. Pharmacol. Exp. Ther. 283, 1305 (1997), (6) V.A. Edgar, et al., Eur. J. Pharmacol. 372, 65 (1999), (7) P. Bartholoma, et al., Biochem. Pharmacol. 63, 1507 (2002), (8) J.T. Bian, et al., Eur. J. Pharmacol. 453, 159 (2002), (9) A. Zhang, et al., J. Med. Chem. 45, 1930 (2002), (10) P. Svenningsson, et al., PNAS 99, 3182 (2002), (11) L. Perez-Caballero, et al., Expert Opin. Drug Discov. 9, 567 (2014)
Quantity	10 mg, 50 mg, Bulk