Available from stock

Fluticasone propionate

SKU: F0325

Category: Steroids

Synonyms: Fluticasone 17-Propionate , (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester , CCI 18781; 80474-14-2
CAS-Number: C₂₅H₃₁F₃O₅S
Molecular Formula: 500.57
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥97% (NMR)
Appearance: White powder
Identity: 1H-NMR

Properties

Solvents: DMSO (20 mg/ml), DMF (20 mg/ml)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: RT
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at RT.

Transportation: Not dangerous goods
For Research Use Only: Not Intended for Diagnostic or Therapeutic Use.

Description: Fluticasone propionate is a synthetic corticosteroid. It is a high affinity, selective glucocorticoid receptor agonist (Kd = 0.5nM). It is used as an anti-inflammatory agent for asthma. It has low systemic bioavailability and has been investigated for effectiveness as an inhaled or intranasal corticosteroid to reduce airflow obstruction related to asthma, allergic rhinitis and other airway diseases. It potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis in vitro. It also potentiates KV1 channels (EC50 = 37nM).
Smiles: O[C@H]1C[C@@]2(C)[C@](C[C@@H](C)[C@]2(OC(CC)=O)C(SCF)=O)([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@]31F)=O
InChi Key: WMWTYOKRWGGJOA-CENSZEJFSA-N
References: (1) M. Johnson, Allergy 50, 11 (1995) (Review) , (2) M. Johnson, Int. Arch. Allergy Immunol. 107, 439 (1995) (Review) , (3) R. Fuller, et al., Respir. Med. 89, 3 (1995) (Review) , (4) C.L. Smith & W. Kreutner, Arzneim.-Forsch. 48, 956 (1998) , (5) X. Zhang, et al., Eur. J. Pharmacol. 406, 325 (2000) , (6) Y. Pan, et al., ACS Chem Biol. 7, 1641 (2012) , (7) J. Sastre & R. Mosges, J. Investig. Allergol. Clin. Immunol. 22, 1 (2012) , (8) J. Gonzalez-Cervera & A.J. Lucendo, J. Investig. Allergol. Clin. Immunol. 26, 8 (2016)
InChi: InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1

Fluticasone propionate is a synthetic corticosteroid. It is a high affinity, selective glucocorticoid receptor agonist (Kd = 0.5nM). It is used as an anti-inflammatory agent for asthma. It has low systemic bioavailability and has been investigated for effectiveness as an inhaled or intranasal corticosteroid to reduce airflow obstruction related to asthma, allergic rhinitis and other airway diseases. It potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis in vitro. It also potentiates KV1 channels (EC50 = 37nM).

SKU: F0325 Category: Steroids

Additional information

Additional information

Synonyms	Fluticasone 17-Propionate, (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester, CCI 18781
Purity	≥97% (NMR)
Appearance	White powder
CAS-Number	80474-14-2
Molecular Formula	C25H31F3O5S
Molecular Weight	500.57
Identity	1H-NMR
Solvents	DMSO (20 mg/ml), DMF (20 mg/ml)
Smiles	O[C@H]1C[C@@]2(C)[C@](C[C@@H](C)[C@]2(OC(CC)=O)C(SCF)=O)([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@]31F)=O
InChi Key	WMWTYOKRWGGJOA-CENSZEJFSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Transportation	Not dangerous goods
References	(1) M. Johnson, Allergy 50, 11 (1995) (Review), (2) M. Johnson, Int. Arch. Allergy Immunol. 107, 439 (1995) (Review), (3) R. Fuller, et al., Respir. Med. 89, 3 (1995) (Review), (4) C.L. Smith & W. Kreutner, Arzneim.-Forsch. 48, 956 (1998), (5) X. Zhang, et al., Eur. J. Pharmacol. 406, 325 (2000), (6) Y. Pan, et al., ACS Chem Biol. 7, 1641 (2012), (7) J. Sastre & R. Mosges, J. Investig. Allergol. Clin. Immunol. 22, 1 (2012), (8) J. Gonzalez-Cervera & A.J. Lucendo, J. Investig. Allergol. Clin. Immunol. 26, 8 (2016)
InChi	InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1
Quantity	5 mg, 25 mg, Bulk