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    Folic acid

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      Folic acid

      SKU
      F0230

      Category: Vitamins

      Synonyms
      PteGlu , Pteroyl-L-glutamic acid , Vitamin M
      59-30-3
      CAS-Number
      C19H19N7O6
      Molecular Formula
      441.40
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥95% (HPLC)
      Appearance
      Yellow to orange crystalline powder
      Identity
      1H-NMR

      Properties

      Solvents
      water (1.6 mg/ml), 1 M NaOH (50 mg/ml), methanol (slightly), diluted acids, alkaline solutions
      Melting Point
      285° C

      Documentation

      Safety Data Sheet (SDS)
      CDX F0230 MSDS.pdf
      Shipping
      AMBIENT
      Short Term Storage
      RT
      Long Term Storage
      +4°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Transportation
      Not dangerous goods
      Description
      Folic acid, also known as folate, is a B vitamin is an essential nutritional component of the human diet. It is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis, and for preventing changes to DNA, and consequently cancer. It is especially important during periods of frequent cell division and growth, such as infancy and pregnancy. Folate is needed to carry one-carbon groups for methylation reactions and nucleic acid synthesis. Folic acid deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of their greater frequency of cell division. Both adults and children need folate to make normal red and white blood cells and prevent anemia. Deficiency of folic acid in pregnant women has been implicated in neural tube defects (NTD).
      Smiles
      O=C(O)[C@](NC(C1=CC=C(NCC2=NC3=C(N=C2)N=C(N)NC3=O)C=C1)=O)([H])CCC(O)=O
      InChi Key
      OVBPIULPVIDEAO-LBPRGKRZSA-N
      References
      B. Kamen, Se≥ Oncol. 24, S18-30 (1997) , Y.I. Kim, Nutr. Rev. 57, 314 (1999) , S.W. Choi & J.B. Mason, J. Nutr. 130, 129 (2000) , P. Mastroiacovo & E. Leoncini, Biofactors 37, 272 (2011) , S.Y. Taylor, et al., Eur. J. Pharmacol. 714, 193 (2013) , N. Laurieri, et al., PLoS One 9, e96370 (2014) , S.Y. Hwang, et al., Int. J. Mol. Med. 36, 1073 (2015) , H.N. Moussa, et al., Future Sci. OA. 2, 2 (2016)
      InChi
      InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

      Folic acid, also known as folate, is a B vitamin is an essential nutritional component of the human diet. It is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis, and for preventing changes to DNA, and consequently cancer. It is especially important during periods of frequent cell division and growth, such as infancy and pregnancy. Folate is needed to carry one-carbon groups for methylation reactions and nucleic acid synthesis. Folic acid deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of their greater frequency of cell division. Both adults and children need folate to make normal red and white blood cells and prevent anemia. Deficiency of folic acid in pregnant women has been implicated in neural tube defects (NTD).

      SKU: F0230 Category: Vitamins
      • Additional information

      Additional information

      Synonyms

      PteGlu, Pteroyl-L-glutamic acid, Vitamin M

      Purity

      ≥95% (HPLC)

      Appearance

      Yellow to orange crystalline powder

      CAS-Number

      59-30-3

      Molecular Formula

      C19H19N7O6

      Molecular Weight

      441.40

      Identity

      1H-NMR

      Solvents

      water (1.6 mg/ml), 1 M NaOH (50 mg/ml), methanol (slightly), diluted acids, alkaline solutions

      Melting Point

      285° C

      Smiles

      O=C(O)[C@](NC(C1=CC=C(NCC2=NC3=C(N=C2)N=C(N)NC3=O)C=C1)=O)([H])CCC(O)=O

      InChi Key

      OVBPIULPVIDEAO-LBPRGKRZSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Transportation

      Not dangerous goods

      References

      B. Kamen, Se≥ Oncol. 24, S18-30 (1997), Y.I. Kim, Nutr. Rev. 57, 314 (1999), S.W. Choi & J.B. Mason, J. Nutr. 130, 129 (2000), P. Mastroiacovo & E. Leoncini, Biofactors 37, 272 (2011), S.Y. Taylor, et al., Eur. J. Pharmacol. 714, 193 (2013), N. Laurieri, et al., PLoS One 9, e96370 (2014), S.Y. Hwang, et al., Int. J. Mol. Med. 36, 1073 (2015), H.N. Moussa, et al., Future Sci. OA. 2, 2 (2016)

      InChi

      InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

      Quantity

      25 g, 100 g, Bulk

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